Working memory theory of hippocampal function needs qualification

To compare the predictive value of "cognitive map" and "working memory" theories of hippocampal function, the performance of rats with dorsal hippocampal lesions was compared to that of control rats in a series of experiments. In Experiment I, experimental rats learned a spatial alternation task with normal ease, but in Experiment II, they were significantly impaired on an elevated 8-arm radial maze. In Experiment III, the performance of the same experimental and control rats was compared on two versions of a 16-arm enclosed radial maze. In the first version, carpet inserts served as cues to mark eight unbaited arms and each of the remaining arms contained one food pellet. While both experimental and control rats successfully avoided the set of cued arms, experimental rats reentered uncued baited arms more frequently than did control rats. In the second version no intramaze cues were provided, but the spatial distribution of baited and unbaited arms remained the same as that used in the first version. In this uncued version, experimental rats both entered unbaited arms and reentered baited arms more frequently than did control rats, i.e., they were impaired in both "reference" and "working" memory. These findings are compatible with the hypothesis that hippocampal lesions result in an impaired capacity to form cognitive maps but they are not compatible with the working memory hypothesis. Furthermore, twelve separate evaluators classed experimental rats as using fewer mapping and more orientation strategies than control rats in the 8-arm maze.     

Stimulus selection in passive avoidance learning and retention: weanling, periadolescent, and young adult rats

Periadolescent rats exhibit a number of behavioral differences in comparison with younger or older animals. For instance, periadolescents tend to show enhanced acquisition of simple active avoidance tasks, but impaired acquisition of more complex appetitive and aversive discriminations. In this experiment, rats were trained on a simple passive avoidance task at one of three ages, as weanlings (25 days), periadolescents (35 days), or young adults (45 days). Training occurred in the presence of both a redundant discriminative stimulus and a specified, redundant contextual stimulus. The periadolescents did not differ from either younger or older rats in rate of learning the passive avoidance task. The retention performance of these animals was then tested following a change in either, neither, or both of the redundant cues. When a measure of performance that controls for baseline activity was used, it was observed that periadolescents were not disrupted by a change in the redundant discriminative stimulus, a cue change that clearly disrupted performance in 25- and 45-day-old animals, and tended to be more disrupted by the contextual change than younger or older rats. It is hypothesized that the alterations in performance exhibited by periadolescents may be related to an ontogenetic alteration in stimulus selection modulated by the catecholaminergic systems.     

The formalin test and the opioid nature of stress-induced analgesia

Exposure to electric shock produces an analgesic reaction (SIA) that is reversed by opiate antagonists ("opioid" SIA) under some conditions but not under other conditions ("nonopioid" SIA). A number of studies using tail-flick to radiant heat as the measure of pain sensitivity have found that a small number of shocks lead to nonopioid SIA, while a large number of shocks produce opioid SIA. In contrast, a small number of shocks have been reported to produce opioid SIA when the Formalin test was used to measure pain reactivity. However, the Formalin test involves administering a chronic pain stimulus (injection of Formalin into the paw) for an extended period before the shocks. Here it is reported that this "preexperimental" stress is sufficient to convert the SIA after a small number of shocks measured by tail-flick to the opioid form.     

The temporal structure of motivation. V. A within-episodes analysis of priming and provocation

Rats provided with chronic, continuous access to intracranial self-stimulation (ICS) exhibit discrete episodic response patterns. Response episodes under two conditions were examined for systematic trends in the spacing of times between successive responses (interresponse times; IRTs) to better identify the motivational bases of ICS. Three trends were observed in self-initiated and experimenter-provoked episodes. First, initial responses of spontaneous episodes typically had declining interresponse times. Second, this trend was not present when responses were provoked rather than spontaneous. Third, absolute times between responses varied across conditions, with provoked behavior having significantly lower initial IRTs. The findings suggest that for spontaneously initiated responding a transient facilitatory process cumulates at the beginning of ICS episodes. For provoked responding, it is possible that a manipulation which increased the initial probability of responding over time may have done so by maximizing an initial phasic priming process. At their onset, spontaneous and provoked episodes may be characterized by quantitatively differing motivational profiles.     

Subfertility among the very intelligent: An examination of the American Mensa

Recent data on post-war birth cohorts in the U.S.A. show a negative relationship between IQ and fertility, both actual and expected. Previous investigators (e.g. Bajema, the Reeds and Waller) had found a slightly positive relationship for certain pre-war birth cohorts. This secular change in the relationship between IQ and fertility is replicated here for data on the membership of the American Mensa. Members born before the war exhibit a fertility below but close to that of the equivalent cohorts in the nation as a whole. Members born during and after the war exhibit a fertility that is substantially lower than that of the equivalent national cohorts. Apparently, rising fertility, which characterized the period in which the pre-war birth cohorts bore their children, causes a convergence in birth rates across IQ classes. Declining and/or low fertility, which characterizes the period in which the post-war birth cohorts are bearing their children, has the opposite effect, i.e. a divergence in birth rates across IQ classes, with the lower birth rates in the higher-IQ classes. The membership of Mensa may not be a representative sample of the high-IQ population as a whole, as it seems to attract a disproportionate number of low procreators even for this population. However, there is no reason to believe that changes in fertility rates across cohorts within Mensa, relative to changes in the national fertility rates, do not reliably reflect changes in fertility rates across cohorts within the high-IQ population of the U.S.A. as a whole, again relative to those of the nation, though these rates may be fluctuating around different means.     

Age norms for impulsiveness,venturesomeness and empathy in children

A total of 1505 children (633 boys and 872 girls) completed the I₆ Impulsiveness Questionnaire. Reliabilities, scale intercorrelations and means and standard deviations are given after slight modifications were made to the original scoring key on the basis of factor analyses. Age means for both sexes are also given.     

Development of differences in response latencies to right and left visual fields

Robust lateralization developed in right-handed adults who were asked to judge letter pairs as "same" or "different" during 4608 trials. By the end of the first two blocks (768 trials) "same" responses were favored when presented in the RVF (transmitted directly to the left hemisphere) and "different" responses were favored when presented in the LVF (transmitted direction to the right hemisphere). This gradually reversed over sessions with "same" responses becoming faster for letters presented in the LVF, and "different" responses becoming faster for stimuli presented in the RVF. The laterality acquired under these conditions was cumulative and reproducible, appeared in all 16 subjects, and was preserved between sessions a week apart. The data suggest that laterality is a flexible and reversible characteristic of the human brain even when stimulus and task remain constant.