The borderline hypertensive rat (BHR): A new model for the study of environmental factors in the development of hypertension

While many studies have attempted to produce hypertension through the use of various environmental Stressors, few have succeeded in producing chronic elevations in blood pressure beyond levels considered to be borderline hypertensive (140–160 mm Hg systolic). The problem with most studies stems from the use of genetically normotensive animals and the selection of Stressors to which animals readily adapt. A new approach is suggested, which recognizes the role of genetics in human essential hypertension. Animals with one hypertensive parent do not develop spontaneous hypertension but show a more sensitive cardiovascular response to environmental Stressors than animals with normotensive parents. Preliminary studies revealed that animals with a mixed genetic history of hypertension develop spontaneous borderline hypertension. When subjected to shock-shock conflict, these borderline hypertensive rats (BHR) developed permanent hypertension that failed to abate even after a ten-week, shock-free recovery period. The hypertension was accompanied by elevated heart weight to body weight ratios and by significant cardiac pathology. Subsequent work has demonstrated that these animals also become hypertensive when fed a high-sodium diet. Finally, in a series of exercise studies, we found that BHRs subjected to a shock stressor were protected against stress-induced hypertension if they exercised daily. The potential of this model for studies of the mechanisms by which environmental variables produce permanent hypertension is discussed.     

Appetitive differential conditioning of the rabbit’s jaw movement response

Two experiments examined appetitive differential conditioning of the rabbit’s jaw movement response (JMR) in a two-phase procedure. The first phase entailed reinforced training with one conditioned stimulus (CS+), and the second phase involved intermixed presentations of CS+ and an unreinforced stimulus (CS?). In Experiment 1, CS+ was a 600-Hz tone, and CS-was either a 660-,1,000-, or 2,100-Hz tone. In Experiment 2, the magnitude of the water unconditioned stimulus (US) paired with CS+ was either 1, 3, or 9 ml. The experiments revealed that 1) the level of responding to CS-rose for several days and then declined over the remainder of training; 2) the physical similarity between CS+ and CS?directly affected the level of responding to CS?but had no discernable effect on the level of responding to CS+ ; and 3) US magnitude positively affected the level of responding to CS + and, to a lesser extent, CS?. The results are discussed in terms of their implications for Spence’s gradient interaction theory and Pavlov’s external inhibition hypothesis.     

Achromatic color categories

Sternheim and Boynton’s (1966) continuous judgmental color-naming technique was used to assess the elemental nature of achromatic colors. Results from three subjects indicate that the names “black” and “white” are necessary and sufficient to describe achromatic test lights associated with the name “gray.” On the basis of the criteria that establishes a color as elemental, black and white were confirmed as elemental, whereas gray was not. These findings support the assumption of various opponent processing models that there are only two elemental achromatic sensations. In addition, the results support Hering’s (1920) view that black and white differ from the paired-chromatic opponent colors in that they are not mutually exclusive.     

Illusory figures: Individual differences apparent depth and lightness

When the luminance of a pattern that induces a sharp-edged illusory circle was decreased, both illusory contrast with the surround and the illusory depth difference between that circular area and the inducing elements reliably increased. Thus, changes in both of these effects apparently participate in (contribute to) the increased overall salience that had previously been found with decreased luminance. However, among individuals, the correlation between this improvement in contrast and this increase in depth was exceedingly small.     

Infants’ sensitivity to familiar size: The effect of memory on spatial perception

Two experiments investigated infants’ sensitivity to familiar size as information for the distances of objects with which they had had only brief experience. Each experiment had two phases: a familiarization phase and a test phase. During the familiarization phase, the infant played with a pair of different-sized objects for 10 min. During the test phase, a pair of objects, identical to those seen in the familiarization phase but now equal in size, were presented to the infant at a fixed distance under monocular or binocular viewing conditions. In the test phase of Experiment 1, 7-month-old infants viewing the objects monocularly showed a significant preference to reach for the object that resembled the smaller object in the familiarization phase. Seven-month-old infants in the binocular viewing condition reached equally to the two test phase objects. These results indicate that, in the monocular condition, the 7-month-olds used knowledge about the objects’ sizes, acquired during the familiarization phase, to perceive distance from the test objects’ visual angles, and that they reached preferentially for the apparently nearer object. The lack of a reaching preference in the binocular condition rules out interpretations of the results not based on the objects’ perceived distances. The results, therefore, indicate that 7-month-old infants can use memory to mediate spatial perception. The implications of this finding for the debate between direct and indirect theories of visual perception are discussed. In the test phase of Experiment 2,5-month-old infants viewing the objects monocularly showed no reaching preference. These infants, therefore, showed no evidence of sensitivity to familiar size as distance information.     

Infants’ sensitivity to the depth cue of shading

Five- and 7-month-old infants were tested for sensitivity to the depth cue of shading. Infants were presented with two displays: a surface in which a convexity and a concavity were molded and a photograph in which shading specified a convexity and a concavity. Each display was presented under both monocular and binocular viewing conditions. Reaching was observed as the dependent measure. Infants in both age groups reached preferentially for the actual convexity in both the monocular and binocular viewing conditions. In the monocular photograph condition, the 7-month-olds reached preferentially for the apparent convexity specified by shading, indicating that they perceived it to be an actual convexity. These infants showed no significant reaching preference in the binocular photograph condition. This finding rules out interpretations of the infants’ reaching not based on perceived depth. The results therefore suggest that the 7-month-olds perceived depth from shading. The 5-month-olds showed no significant reaching preferences when viewing the photograph; thus, they showed no evidence of depth perception from shading. These findings are consistent with the results of a number of studies that have investigated infants’ sensitivity to pictorial depth cues. Together, these studies suggest that the ability to perceive depth from pictorial cues may first develop between 5 and 7 months of age.     

Psychoanalysis of the older patient

A small informal poll of local colleagues revealed that despite their interest in the subject, many had doubts about the possibility of analyzing persons aged sixty or over successfully. Their specific questions are collated and are offered as a sample of the questions in the minds of many analysts everywhere. Selected material from the ongoing analysis of a sixty-four-year-old patient is presented that bears on some of the questions raised. In addition, changes in the patient are noted. These are discussed in terms of changes in function, which are equated with structural change. The major thrust of the paper is that development continues throughout the life course, and that the criteria for analyzability remain constant. The chronological age of the adult by itself is not an indicator of eligibility or of suitability for psychoanalysis.