Determination of dipeptidyl aminopeptidase activities in the cerebrospinal fluid

The investigation of enzyme activity in cerebrospinal fluid has been without relevant results for laboratories analysing spinal fluid. For neurochemical purposes, it is interesting that the Substance P is convered by Depeptidyl-aminopeptidase IV (DP IV), liberating dipeptides. The hydrolysis of nitroanilids of the form Xaa-Pro-NHNp in cerebrospinal fluid was analysed using them as peptidases substrates. Finally a method for measuring the activity was proposed.     

Catamnestic surveys on somato-psychosocial development in childhood and adolescence of patients with unipolar depressive and bipolar manic-depressive psychoses

The somatic and psychosocial development of 80 subjects with manifest affective-phasic psychoses is studied retrospectively and compared with that of an identically sized control group consisting of neuropsychiatrically healthy subjects. Statistically significant differences were found particularly in the answers to questions dealing with social situation and social adaptability. Achievement at school and vocational qualifications were lower among the parents of the patients than among those of the healthy subjects. Characteristic features of the patients' childhood and adolescence were transient depression, often for no apparent cause, and maladaption, and vocational wishes were fulfilled less often than among the controls. The patients experienced greater difficulty in settling in to a new group due to their contact difficulties.     

Perception of structure in novel music

Two experiments demonstrated the way in which musicians and nonmusicians process realistic music encountered for the first time. A set of tunes whose members were related to each other by a number of specific musical relationships was constructed. In Experiment 1, subjects gave similarity judgments of all pairs of tunes, which were analyzed by the ADDTREE clustering program. Musicians and nonmusicians gave essentially equivalent results: Tunes with different rhythms were rated as being very dissimilar, whereas tunes identical except for being in a major versus a minor mode were rated as being highly similar. In Experiment 2, subjects learned to identify the tunes, and their errors formed a confusion matrix. The matrix was submitted to a clustering analysis. Results from the two experiments corresponded better for the nonmusicians than for the musicians. Musicians presumably exceed nonmusicians in the ability to categorize music in multiple ways, but even nonmusicians extract considerable information from newly heard music.     

A demonstration of the costs and benefits of expertise in recognition memory

In their area of expertise experts know more potentially interfering facts than nonexperts do, yet their memory IS superior to that of nonexperts. This has been termed the “paradox of interference.” We proposed that the ability of experts to go beyond the information given allows them to infer the presence of items that might not otherwise be remembered. However, such inferences can also be detrimental to accurate recognition memory in that such inferences might become confused with actual targets. We examined the benefits and costs of expertise in two recognition memory experiments In which experts and nonexperts participated. Experts in Ex-penment 1 were knowledgeable about baseball; those in Experiment 2 were knowledgeable about Ohio geography. Distractors in both studies bore a synonymous, an inferential, or no special relation to the targets. In the last instance, experts had recognition memory superior to that of the nonexperts. When the distractors were related to the targets, however, the non-experts were superior. We proposed that experts' inferential behavior is a contributor to their generally superior memory, but that task demands can convert this asset into a liability.     

Humean nomic essentialism

Humeanism – the idea that there are no necessary connections between distinct existences – and Nomic Essentialism – the idea that properties essentially play the nomic roles that they do – are two of the most important and influential positions in the metaphysics of science. Traditionally, it has been thought that these positions were incompatible competitors. We disagree. We argue that there is an attractive version of Humeanism that captures the idea that, for example, mass essentially plays the role that it actually does in the laws of nature. In this paper we consider the arguments that have lead many to conclude that Humeanism cannot be combined with Nomic Essentialism; we identify the weaknesses in these arguments; and we argue in detail that a version of Humeanism based on a variant of the Best System account of laws captures the key intuitions behind nomic essentialism.