神经质人格迫选量表的开发及其抗作假效果研究

传统的迫选量表得分是自模式数据,最近提出的Thurstone IRT模型建构了被试对迫选量表反应的数学模型,能够更精确地度量被试的特质水平.研究自编了神经质人格迫选量表,与常用的测量神经质的Likert量表一起,在无压力、模拟应聘和实际应聘三种情境下进行施测.结果发现,迫选量表的实测数据能够较好地拟合Thurstone IRT模型,该模型估计的特质得分不具有自模式数据的性质,比传统计分更能够抵抗作假.无论采用哪种计分方式,迫选量表都比Likert量表更能够抵抗作假.     

Unconsciously learning task-irrelevant perceptual sequences

We demonstrated unconscious learning of task-irrelevant perceptual regularities in a Serial Reaction Time (SRT) task in both visual and auditory domains. Participants were required to respond to different letters (‘F’ or ‘J’, experiment 1) or syllables (‘can’ or ‘you’, experiment 2) which occurred in random order. Unbeknownst to participants, the color (red, green, blue or yellow) of the two letters or the tone (1–4) of the syllables varied according to certain rules. Reaction times indicated that people indeed learnt both the color and tonal regularities indicating that task-irrelevant sequence structure can be learned perceptually. In a subsequent prediction test of knowledge of the color or tonal cues using subjective measures, we showed that people could acquire task irrelevant knowledge unconsciously.     

The nature of the memory buffer in implicit learning: Learning Chinese tonal symmetries

Previous research has established that people can implicitly learn chunks, which (in terms of formal language theory) do not require a memory buffer to process. The present study explores the implicit learning of nonlocal dependencies generated by higher than finite-state grammars, specifically, Chinese tonal retrogrades (i.e. centre embeddings generated from a context-free grammar) and inversions (i.e. cross-serial dependencies generated from a mildly context-sensitive grammar), which do require buffers (for example, last in-first out and first in-first out, respectively). People were asked to listen to and memorize artificial poetry instantiating one of the two grammars; after this training phase, people were informed of the existence of rules and asked to classify new poems, while providing attributions of the basis of their judgments. People acquired unconscious structural knowledge of both tonal retrogrades and inversions. Moreover, inversions were implicitly learnt more easily than retrogrades constraining the nature of the memory buffer in computational models of implicit learning.     

胰岛再生治疗的前景

胰岛β细胞数量减少和功能障碍是糖尿病的根本原因,现有的治疗手段主要以维持正常血糖水平为主要目的,尚无有效恢复受损胰岛功能的治愈性治疗手段。胰岛再生治疗将是一种可以恢复受损胰岛功能、改变糖尿病自然病程的崭新治疗手段。目前现有的噻唑烷二酮、肠促胰岛素及类似物、二肽基肽酶-4抑制剂等治疗,虽然不是一类新的胰岛再生药物,但其具有一定的促进胰岛再生、改善胰岛功能的作用。体外诱导β细胞再生也将为胰岛移植提供新的来源,为治愈糖尿病带来曙光。     

加强西方伦理思想史研究，建设社会主义精神文明

在召开中国伦理学会成立30周年的庆典大会之际,让我们对伦理学研究所走过的历程以及西方伦理思想史这30年来的研究,进行一次简短的历史回顾。西方伦理思想史的研究分为两个方面:对西方     

神意、理性与权利——一种关于洛克自然法理论的解读

洛克对自然法的性质进行了详细的阐述,得出了自然法具有神意法和理性法双重属性的结论.这种性质界定具有模糊性,而且神意法与理性法在一定程度上是互相冲突的,因此受到后来学者的诟病;但洛克自然法理论中的这种模糊性源自其对于由理性所开启的现代性进程之谨慎态度.尽管洛克在一定程度上似乎更重视理性的作用,但理性也存在诸多问题:自然法是人类理性无法独证的,对于理性的偏执会在认识论上因缺乏根基而显得武断,而且自然法在政治上的应用及其说服力,仅仅依靠理性推演也是不够的.这些考虑最终使洛克走向一种谨慎的平衡策略-自然法既是神意法,也是理性法.此外,洛克还从上帝存在这一基本背景出发,引申出了人类应当服从的三类自然法义务,并从这三类自然法义务中推导出了人类的三大基本权利:生命、财产与自由,近代权利思想实发轫于此.     

Attenuated response to methamphetamine sensitization and deficits in motor learning and memory after selective deletion of β-catenin in dopamine neurons

In the present study, we analyzed mice with a targeted deletion of β-catenin in DA neurons (DA-βcat KO mice) to address the functional significance of this molecule in the shaping of synaptic responses associated with motor learning and following exposure to drugs of abuse. Relative to controls, DA-βcat KO mice showed significant deficits in their ability to form long-term memories and displayed reduced expression of methamphetamine-induced behavioral sensitization after subsequent challenge doses with this drug, suggesting that motor learning and drug-induced learning plasticity are altered in these mice. Morphological analyses showed no changes in the number or distribution of tyrosine hydroxylase-labeled neurons in the ventral midbrain. While electrochemical measurements in the striatum determined no changes in acute DA release and uptake, a small but significant decrease in DA release was detected in mutant animals after prolonged repetitive stimulation, suggesting a possible deficit in the DA neurotransmitter vesicle reserve pool. However, electron microscopy analyses did not reveal significant differences in the content of synaptic vesicles per terminal, and striatal DA levels were unchanged in DA-βcat KO animals. In contrast, striatal mRNA levels for several markers known to regulate synaptic plasticity and DA neurotransmission were altered in DA-βcat KO mice. This study demonstrates that ablation of β-catenin in DA neurons leads to alterations of motor and reward-associated memories and to adaptations of the DA neurotransmitter system and suggests that β-catenin signaling in DA neurons is required to facilitate the synaptic remodeling underlying the consolidation of long-term memories.     

意外地点任务中不同测试问题及意图理解与执行功能的关系

旨在讨论意外地点任务中“知否问题”与“预测问题”可能存在的差异及两者与执行功能任务的关系,并初步探讨意图理解与执行功能间的关系。用意外地点任务、膝跳反射任务和两个执行功能的任务（DCCS和手部游戏）对59名3~5岁的儿童施测。结果显示：（1）儿童在意外地点任务的“知否问题”上的表现显著好于“预测问题”,儿童对“知否问题”和“预测问题”的回答可能反映了心理理论发展的不同阶段。（2）膝跳反射任务,DCCS任务与“知否问题”三者间有显著的相关,且其高相关在排除年龄及语言能力的影响后仍保持显著。“双表征区分结构”可能是三者间具有共同的成分。     

慢性阻塞性肺疾病健康教育的作用及面临的问题

将82例稳定期COPD患者随机分为两组,治疗组接受为期半年的健康教育,对照组不接受健康教育.观察半年前后两组的吸烟比例、呼吸困难评分、吸入治疗比例及正确率和半年内急性发作次数;并比较半年前后的生活质量评分、疗效评估和肺功能指标.发现:半年的健康教育可增加稳定期COPD患者的戒烟率,减少反复急性发作,从而提高生活质量.缺乏经济效益及未受到足够的重视和宣传,制约了健康教育的普及,因此发展社区卫生医疗服务势在必行.     

自然宗教的特质和文化意义——以西南少数民族为例

自然宗教最基本的教义特征是把自然力人格化并重巫术,因而试图把这类宗教从很多研究者定义为的“初级宗教”或“原始宗教”还原为“自然宗教”,把其视为一种独特的宗教类型来看。对自然宗教的研究其文化意义从理论上讲是对长期的已然存在的自然宗教社会事实的确认,对以往原始宗教认识的深化和发展,从实践上讲可以为我国民族地区的宗教事务管理提供整套的资料储备和历史借鉴,对防范宗教信仰失控,维护民族地区的安定将发挥重大的作用。