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71.
72.
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment 总被引:1,自引:0,他引:1 下载免费PDF全文
Shum FW Wu LJ Zhao MG Toyoda H Xu H Ren M Pinaud R Ko SW Lee YS Kaang BK Zhuo M 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(4):304-312
Exposure to an enriched environment (EE) has been shown to induce cortical plasticity. Considerable amount of research is focused on the effects of EE in the hippocampus; however, effects of EE on other brain regions and the mechanisms involved are not well known. To investigate this, we induced cortical plasticity by placing mice in an EE for one month and measured the effects of EE in the anterior cingulate cortex (ACC). Here, we show that EE enhanced the expression of the plasticity gene, egr-1, in the ACC of EE animals accompanied by enhanced cingulate long-term potentiation (LTP) and decreased cingulate long-term depression (LTD). The increased NMDA receptor NR2B/NR2A subunits current ratio is associated with the plasticity seen in the ACC while total protein levels remain unchanged. Furthermore, behavioral experiments show that these mice exposed to EE demonstrate enhanced responses to acute and long-term inflammation. Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation. 相似文献
73.
The role of ambiguity tolerance in career decision making was examined in a sample of college students (n = 275). Three hypotheses were proposed regarding the direct prediction of ambiguity tolerance on career indecision, the indirect prediction of ambiguity tolerance on career indecision through environmental and self explorations, and the moderation effect of ambiguity tolerance on the link of environmental and self explorations with career indecision. Results supported the significance of ambiguity tolerance with respect to career indecision, finding that it directly predicted general indecisiveness, dysfunctional beliefs, lack of information, and inconsistent information, and moderated the prediction of environmental exploration on inconsistent information. The implications of this study are discussed and suggestions for future research are provided. 相似文献
74.
20世纪初,太虚大师等人倡导的"人间佛教"运动警醒了明清至民国陷于腐败、堕落的中国佛教,开始了近一个世纪的"人间佛教"运动.进入新世纪,回头分析"人间佛教"的发展,可以从中吸取很多经验,同时也可发现当中存在的问题.笔者提出"都市佛教"理念,以期通过它为"人间佛教"的发展瓶颈找到解决之策. 相似文献
75.
Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice 总被引:3,自引:0,他引:3
Qiu S Korwek KM Pratt-Davis AR Peters M Bergman MY Weeber EJ 《Neurobiology of learning and memory》2006,85(3):228-242
The heterozygote reeler mouse (HRM) shows many neuroanatomical and biochemical features that are also present in some human cognitive disorders, such as schizophrenia. In the present study, hippocampal dependent plasticity and cognitive function of the HRM were characterized in detail in an attempt to reveal phenotypic functional differences that result from Reelin haploinsufficiency. The HRM and wild type mice show similar levels of overall activity, coordination, thermal nociception, startle responses, and anxiety-like behavior. In addition, both genotypes show similar shock threshold, identical cued freezing behavior and comparable spatial learning in Morris water maze tasks. However, a significant reduction in contextual fear conditioned learning was observed in the HRM. Electrophysiological studies in hippocampal CA1 synapses revealed a plethora of differences between genotypes. The HRM exhibits reduced field excitatory postsynaptic potentials in responses to similar synaptic inputs, lowered paired pulse facilitation ratio and impaired long-term depression and tetanus-induced long-term potentiation (LTP). Also, deficits were detected in LTP elicited by theta burst stimulation or by a whole cell pairing protocol. These physiologic differences could not be accounted for by changes in the overall amount of glutamate receptor subunits. In addition, it was determined that network-driven excitatory and inhibitory activities recorded in CA1 pyramidal neurons showed that the HRM had comparable amplitude and frequency of spontaneous excitatory postsynaptic currents, but a marked reduction in spontaneous inhibitory postsynaptic currents. Thus, the HRM exhibits a specific hippocampal-dependent learning deficit accompanied with a pronounced impairment of hippocampal plasticity and functional inhibitory innervation. 相似文献
76.
126 leaders and 624 employees were sampled to test the relationship between sources of motivation and conflict management styles of leaders and how these variables influence effectiveness of leadership. Five sources of motivation measured by the Motivation Sources Inventory were tested-intrinsic process, instrumental, self-concept external, self-concept internal, and goal internalization. These sources of work motivation were associated with Rahim's modes of interpersonal conflict management-dominating, avoiding, obliging, complying, and integrating-and to perceived leadership effectiveness. A structural equation model tested leaders' conflict management styles and leadership effectiveness based upon different sources of work motivation. The model explained variance for obliging (65%), dominating (79%), avoiding (76%), and compromising (68%), but explained little variance for integrating (7%). The model explained only 28% of the variance in leader effectiveness. 相似文献
77.
Understanding the object benefit in visual short-term memory: the roles of feature proximity and connectedness 总被引:2,自引:0,他引:2
Xu Y 《Perception & psychophysics》2006,68(5):815-828
Past research has identified visual objects as the units of information processing in visual short-term memory (VSTM) and has shown that two features from the same object can be remembered in VSTM as well (or almost as well) as one feature of that object and are much better remembered than the same two features from two spatially separated objects. It is not clear, however, what drives this object benefit in VSTM. Is it the shared spatial location (proximity), the connectedness among features of an object, or both? In six change detection experiments, both location/proximity and connectedness were found to be crucial in determining the magnitude of the object benefit in VSTM. Together, these results indicate that location/proximity and connectedness are essential elements in defining a coherent visual object representation in VSTM. 相似文献
78.
Preschoolers' theory-of-mind development follows a similar age trajectory across many cultures. To determine whether these similarities are related to similar underlying ontogenetic processes, we examined whether the relation between theory of mind and executive function commonly found among U.S. preschoolers is also present among Chinese preschoolers. Preschoolers from Beijing, China (N= 109), were administered theory-of-mind and executive-functioning tasks, and their performance was compared with that of a previously studied sample of U.S. preschoolers (N= 107). The Chinese preschoolers outperformed their U.S. counterparts on all measures of executive functioning, but were not similarly advanced in theory-of-mind reasoning. Nonetheless, individual differences in executive functioning predicted theory of mind for children in both cultures. Thus, the relation between executive functioning and theory of mind is robust across two disparate cultures. These findings shed light on why executive functioning is important for theory-of-mind development. 相似文献
79.
Most Chinese characters are composed of a semantic radical on the left and a phonetic radical on the right. The semantic radical provides the semantic information; the phonetic radical provides information concerning the pronunciation of the whole character. The pseudo‐characters in the study consisted of different sub‐lexical parts of real Chinese characters and consequently they also had the semantic radical and the phonetic radical. But they were not readable and had no actual meaning. In order to investigate the spatiotemporal cortical activation patterns underlying the orthographic, phonological and semantic processing of Chinese characters, we used event‐related brain potentials (ERPs) to explore the processing of Chinese characters and pseudo‐characters when 14 healthy Chinese college students viewed the characters passively. Results showed that both Chinese characters and pseudo‐characters elicited an evident negative potential peaking around 120 ms (N120), which appeared to reflect initial orthographic distinction and evaluation. Then, Chinese pseudo‐characters elicited a more positive ERP deflection (P220) than did Chinese characters 200–250 ms after onset of the stimuli. It was similar to the recognition potential (RP) and might reflect the integration processes of phonological and semantic processing on the basis of early orthographic information. Dipole source analysis of the difference wave (pseudo‐characters minus characters) indicated that a generator localized in the left temporal‐occipital junction contributed to this effect, which was possibly related to phonological and perceptual–semantic information integration. Between 350–450 ms, a greater negativity (N360) in pseudo‐characters as compared to characters was found over midline fronto‐central scalp regions. Dipole analysis localized the generator of N360 in the right parahippocampal cortex. Therefore, the N360 might be an N400 component and reflect the higher‐level semantic activation on the basis of orthographic, phonological and perceptual–semantic processing. 相似文献
80.
Discontinuous precipitation in a two-phase Zn-rich Zn-6.3at.%Ag alloy has been studied. It has been shown that the eta/epsilon interphase boundaries have the ability to initiate discontinuous precipitation as do the eta/eta grain boundaries. The back-polishing method is used to show the interconnection between a discontinuous precipitate colony and the eta/epsilon interphase boundary. The reaction front velocity of discontinuous precipitation initiated at the eta/eta grain boundary is 12-90% higher than that of discontinuous precipitation initiated at the eta/epsilon interphase boundary under various ageing temperatures. 相似文献