Activation of amygdaloid PKC pathway is necessary for conditioned cues-provoked cocaine memory performance

Drug-associated cues are critical in reinstating the drug taking behavior even during prolonged abstinence and thus are thought to be a key factor to induce drug craving and to cause relapse. Amygdaloid complex has been known for its physiological function in mediating emotional experience storage and emotional cues-regulated memory retrieval. This study was undertaken to examine the role of basolateral nuclei of amygdala and the intracellular signaling molecule in drug cues-elicited cocaine memory retrieval. Systemic anisomycin treatment prior to the retrieval test abolished the cues-provoked cocaine conditioned place preference (CPP) memory. Likewise, a similar blockade of cues-provoked cocaine CPP performance was achieved by infusion of anisomycin and cycloheximide into the basolateral nuclei of amygdala before the test. Intra-amygdaloid infusion of H89, a protein kinase A inhibitor, or U0126, a MEK inhibitor, did not affect retrieval of the cues-elicited cocaine CPP memory. In contrast, intra-amygdaloid infusion of NPC 15437, a PKC inhibitor, abolished the cues-elicited cocaine CPP expression, while left the memory per se intact. Intra-amygdaloid infusion of NPC 15437 did not seem to affect locomotor activity or exert observable aversive effect. Taken together, our results suggest that activation of PKC signaling pathway and probably downstream de novo protein synthesis in the basolateral nuclei of amygdala is required for the cues-elicited cocaine memory performance. However, temporary inhibition of this signaling pathway does not seem to affect cocaine CPP memory per se.     

Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system

While serotonin (5-HT) may impair learning and memory, exercise has been reported to improve them. Whether chronic exercise can facilitate fear memory via regulating the serotonin system is unknown. We examined the effects of 4-week treadmill exercise training on levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), the protein expression of its receptor 5-HT_1A and transporter in the amygdala, hippocampus and prefrontal cortex of male Sprague–Dawley rats. Our results demonstrated that treadmill exercise (1) improved the passive avoidance learning performance; (2) decreased the 5-HT level in the hippocampus; (3) decreased the expression of 5-HT_1A receptor in the amygdala without altering the transporter expression. Moreover, pretreatment with 0.1 mg/kg 8-hydroxy-di-n-propylamino tetralin, a selective 5-HT_1A receptor agonist, impaired the passive avoidance performance and completely abolished the exercise-enhanced fear memory. Our results suggest that down-regulation of the 5-HT system in the limbic system, i.e., the reduction of the hippocampus 5-HT content and the amygdala 5-HT_1A receptor expression, may be involved in the exercise-enhanced fear memory.     

国外青少年身体活动动机理论及其对体育教育的启示

青少年在身体活动领域参与程度的下降趋势已经成为全球性的问题.目前,国内外研究者们对身体活动行为背后的参与动机给予了广泛的研究.本文对国外青少年身体活动动机研究的理论进行了梳理,在此基础上总结青少年身体活动参与动机的特点,并针对我国的体育教育工作提出建议,为我国的体育教育工作提供参考.     

中国文人山水画折射的生态伦理思想及其当代价值

中国文人山水画通过对自然山水的描绘,来表达作者的主观情趣和精神世界,其中折射出质朴丰富的生态伦理思想。以现代生态伦理观深入挖掘和梳理这一传统文化精华,对正确认识人与自然的关系、化育当代生态审美、推动生态伦理学走向民间具有十分重要的价值。     

从邻域语义学的观点看否定

论文采用否定邻域框架系统地分析了各种弱否定的对应性与典范性。我们讨论了七个与弱否定相关的序列（sequent）,其对应性与典范性如下表所示：与常见的处理弱否定的星框架与相容框架相比,否定邻域框架的处理能力更强,采用后者所得的结果比采用前两者所得的结果更为一般。很多文献中的结果都是本文采用否定邻域框架所得结果的特例。     

Testing the Mediating Effect of the Quality of College Life in the Student Satisfaction and Student Loyalty Relationship

This study tests the mediating effect of the quality of college life (QCL) in the student satisfaction and student loyalty relationship. QCL refers to the degree of need satisfaction and the experiences that create a positive affect throughout college life. The QCL of students is conceptualized as a higher order construct that is composed of need satisfaction and affect balance. It has been hypothesized that student satisfaction with university services has a significant impact on QCL, which in turn positively influences student loyalty. The results from the survey of 228 college students largely supported the model. Both the managerial and policy implications of this study are discussed.

国外已决犯监狱服刑人员自尊研究综述

几十年来,国外学术界对于被监禁人员的自尊问题进行了很多研究,并取得了诸多研究成果。本文对有关已决犯监狱服刑人员的自尊研究进行了简要回顾,对相关研究及其成果进行了简要介绍,对研究的特点、局限进行了总结,并在此基础上尝试提出了未来研究应关注的要点。     

多维测验项目参数的估计：基于SEM与MIRT方法的比较

作者简要回顾了SEM框架下分类数据因素分析(CCFA)模型和MIRT框架下测验题目和潜在能力的关系模型, 对两种框架下的主要参数估计方法进行了总结。通过模拟研究, 比较了SEM框架下WLSc和WLSMV估计方法与MIRT框架下MLR和MCMC估计方法的差异。研究结果表明：(1) WLSc得到参数估计的偏差最大, 且存在参数收敛的问题; (2)随着样本量增大, 各种项目参数估计的精度均提高, WLSMV方法与MLR方法得到的参数估计精度差异很小, 大多数情况下不比MCMC方法差; (3)除WLSc方法外, 随着每个维度测验题目的增多参数估计的精度逐渐增高; (4)测验维度对区分度参数和难度参数的影响较大, 而测验维度对项目因素载荷和阈值的影响相对较小; (5)项目参数的估计精度受项目测量维度数的影响, 只测量一个维度的项目参数估计精度较高。另外文章还对两种方法在实际应用中应该注意的问题提供了一些建议。     

汉语双字词超音段信息在语义激活中的作用

采用眼动方法,通过两个实验考察了汉语双字词超音段信息在语义激活中的作用。结果显示：（1）汉语双字词语义激活过程中,分别改变首字声调和尾字声调对语义激活起到抑制作用,首字声调改变时的抑制作用更大。结果支持了Cohort模型。（2）语义相关词的注视点和注视时间远远多于其控制词,但没有发现词频效应。（3）汉语声调的加工过程与声韵母一样,独立作用于语义激活过程。     

基于Q矩阵和广义距离的认知诊断方法

规则空间方法(RSM)和属性层级方法(AHM)是两种重要的认知诊断方法, 近年来受到了广泛关注。本文在属性层级方法和丁树良等人(2009, 2010)改进的Q矩阵理论的基础上, 通过定义观察反应模式与理想反应模式之间的广义距离, 给出了一种识别被试知识状态的认知诊断方法, 即广义距离判别法。通过DINA模型生成被试的作答反应矩阵进行模拟研究, 以模式判准率和属性判准率作为衡量被试知识状态分类准确率指标, 将广义距离判别法、RSM和AHM的分类A方法分别与DINA模型进行比较。结果表明, 本文提出的广义距离判别法具有更好的分类效果。