Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice

Cognitive functions usually involve various synaptic proteins and neurotrophic factors in the hippocampus. However, whether treadmill exercise can improve learning and memory by upregulating some of these molecules remain unraveled. To address this question, male BALB/c mice were divided into control and exercise groups, the latter group went through 4 weeks of treadmill exercise training. At the end of exercise training period, they were either tested for passive avoidance (PA) performance or sacrificed for quantifying the hippocampal levels of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB, the BDNF receptor), synaptotagmin (a Ca²⁺-dependent synaptic vesicle protein), and SNAP-25 (a presynaptic vesicular fusion protein). Our results showed that treadmill exercise training (1) increased the retention latency without affecting the fear acquisition in the PA test, (2) transiently increased the hippocampal BDNF level at 1, 2, and 4 h after the completion of exercise training, and (3) persistently increased the hippocampal protein levels of full-length TrkB, phosphorylated TrkB and synaptotagmin, but not truncated TrkB or SNAP-25. Moreover, the protein expression level of full-length TrkB or synaptotagmin was positively correlated with PA performance in mice. Finally, inhibition of TrkB signaling by K252a abolished the exercise-facilitated PA performance and upregulation of TrkB and synaptotagmin. Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory.     

基于胜任特征的结构化面试初探

基于胜任特征的结构化面试是对传统结构化面试的优化,有很高的信度和效度。本文从基于胜任特征的结构化面试的内涵、特点、程序以及实施过程中需要注意的问题几个方面进行了深入探讨,对于改善结构化面试的测评功能和深化胜任特征的应用有一定价值。     

环境中的风险认知特征

采用多维度的心理测量范式,研究公众在“影响程度”、“可控性”、“了解程度”、“影响的持续性”、“发生的可能性”、“结果的严重性”六个维度上对39个环境条目的风险认知特征。研究结果验证了“风险程度指标”,并将环境风险划分为“生态环境”“疾病与灾害”“生活环境”三个大类并探讨其风险认知特征。结果显示,由“客观认识”和“主动作用”两维度形成的认知地图可有效地指导风险沟通。     

组织管理诚信与组织承诺之关系研究

本研究的主要目的乃探讨组织管理诚信的内涵及现状;揭示组织管理诚信与组织承诺之关系。通过文献分析和问卷调查,研究者发现:组织管理诚信行为主要包含诚实、守信、诚直和精诚四个方面的内容;员工对当前组织管理的评价总体趋向于诚信,其中对守信因子的评价最高,对诚直因子的评价最低;组织管理诚信对组织承诺存在着积极的影响。     

Thing, Value, Time, and Freedom: A Consideration of Some Key Concepts in Marx’s Philosophical System

Criticizing the misunderstanding and wrong explanation of Marx’s philosophical system made by recent Chinese textbooks on Marxist philosophy, the author argues that Marx’s philosophy has practical, economical-philosophical, and ontological dimensions and stresses on reconstructing Marx’s philosophical system through synthesizing the above three dimensions. This paper intends to set up a new outline of Marx’s philosophical system, in terms of the following four concepts—thing, value, time, and freedom. Translated by Tang Jie from Zhexue Yanjiu, 2004:11     

Bidirectional Mediating Role of Loneliness in the Association Between Shyness and Generalized Pathological Internet Use in Chinese University Students: A Longitudinal Cross-Lagged Analysis

Abstract

This 1-year longitudinal study examined the bidirectional mediating role of loneliness in the association between shyness and generalized pathological Internet use (GPIU) in a sample of 291 Chinese university students (143 men, mean age =?19.07?years). A fully cross-lagged panel design was used in which shyness, loneliness, and GPIU were assessed at 3 time points separated by 6-month intervals (named T1, T2, and T3). The results indicated that relationships among shyness, loneliness, and GPIU were dynamic and bidirectional. Specifically, T1 shyness positively predicted increased T2 loneliness, T2 shyness positively predicted increased T3 loneliness, and T2 loneliness positively predicted increased T3 shyness. Additionally, T1 GPIU positively predicted increased T2 loneliness, T2 GPIU positively predicted increased T3 loneliness, and T2 loneliness positively predicted increased T3 GPIU. Loneliness was found to play a bidirectional mediating role in the association between shyness and GPIU. Specifically, T1 shyness and T3 GPIU were mediated through increased loneliness at T2, and T1 GPIU and T3 shyness were mediated through increased loneliness at T2. Furthermore, relationships among shyness, loneliness, and GPIU were the same across the 2 groups, with the strength of relationships being stronger for men.     

Facial expressions can inhibit the activation of gender stereotypes

ABSTRACT

Using faces as the priming stimuli, the present study explored the influence of facial expressions on the activation of gender stereotypes using a lexical decision paradigm. Experiment 1 explored the activation of gender stereotypes when the facial primes contained only gender information. The results showed that gender stereotypes were activated. In Experiment 2, the facial primes contained both gender category and expression information. The results indicated that gender stereotypes were not activated. Experiment 3 required the participants to make emotion, gender, or impression decisions concerning the facial primes before the lexical decision task. The results showed that gender stereotypes were not activated in emotion and impression decisions conditions, whereas stereotypes were activated in gender decisions condition. These finding suggest that facial expressions can inhibit automatic activation of gender stereotypes, unless the perceivers perform gender categorization processing to prime faces intentionally.     

上海城隍庙着力打造学习型、文化型庙观

六年前,上海城隍庙组织全体教职人员参加了华东师范大学宗教班的学习。经过这几年国民学历教育大专阶段和本科阶段的修学,其中部分教职人员已经或将于年内本科毕业。面对这样的好形势,庙管会拓展思路,创新学习机制,以文化学习为基础,全面提高教职人员     

Can unpredicted outcomes be intended? The role of outcome-beliefs in children's judgments of intention

An adult-like concept of intention includes a deliberate action to achieve a goal and a belief that one's action (if successful) will cause the desired outcome. For example, good outcomes caused by accident or by chance are not believed to be caused intentionally. In two experiments, we asked whether children understand this connection between intentions and outcomes. Children played two games in which actions could produce unintended outcomes (i.e., causes were unplanned). Children sometimes received a desirable reward independent of intention. In Experiment 1, 4- and 5-year-olds mistakenly claimed they had intended the desirable outcome even when it was unexpected. Four-year-olds judged that they had not intended a deliberate action if it did not yield a rewarding outcome. Experiment 2 demonstrates that 6-year-olds seldom make these errors. The results suggest that 4- and 5-year-old children have not yet attained an adult-like concept of intention. Their inaccurate judgments regarding their intentions, given a rewarding yet unexpected outcome, can be explained by a positivity bias.     

720名中学生自我同一性地位研究

对中学生自我同一性实证研究表明,中学生自我同一性发展经由一个理慰朦胧——困惑疑为——现实提升的过程。中学生自我同一性地位度数分布中间大,两头小。中学生自我同一性地位存在性别差异。中学生自我同一性地位与学习成效自评交互影响。对中学生自我同一性教育训练应予以重视和加强。