几何图形类比推理的ERP研究

该研究以几何图形作为实验材料,测定14名硕士研究生在完成两种类比推理任务（大小变化和颜色变化）和其基线任务时的事件相关电位（ERP）,探讨类比推理过程的脑内时程动态变化。研究发现,两种推理任务所诱发的波形基本一致,而推理任务与其基线任务之间的ERP波形存在显著差异,两种基线任务之间的ERP波形也存在显著差异;类比推理的加工过程是有阶段性的,即编码潍断、映射、得出结论,研究结果进一步支持了Sternberg的成分理论;推断和映射这两个类比推理所特有的加工阶段都有其对应的脑机制,图式推断阶段主要激活的是前额皮层和双侧的顶叶皮层,类比映射和调整阶段主要激活的是左半球的颞叶、额叶和中央顶。     

Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms

Persistent, bidirectional changes in synaptic signaling (that is, potentiation and depression of the synapse) can be induced by the precise timing of individual pre- and postsynaptic action potentials. However, far less attention has been paid to the ability of paired trains of action potentials to elicit persistent potentiation or depression. We examined plasticity following the pairing of spike trains in the touch mechanosensory neuron (T cell) and S interneuron (S cell) in the medicinal leech. Long-term potentiation (LTP) of T to S signaling was elicited when the T-cell spike train preceded the S-cell train. An interval 0 to +1 sec between the T- and S-cell spike trains was required to elicit long-term potentiation (LTP), and this potentiation was NMDA receptor (NMDAR)-dependent. Long-term depression (LTD) was elicited when S-cell activity preceded T-cell activity and the interval between the two spike trains was -0.2 sec to -10 sec. This surprisingly broad temporal window involved two distinct cellular mechanisms; an NMDAR-mediated LTD (NMDAR-LTD) when the pairing interval was relatively brief (<-1 sec) and an endocannabinoid-mediated LTD (eCB-LTD) when longer pairing intervals were used (-1 to -10 sec). This eCB-LTD also required activation of a presynaptic transient receptor potential vanilloid (TRPV)-like receptor, presynaptic Ca(2+) release from intracellular stores and activation of voltage-gated Ca(2+) channels (VGCCs). These findings demonstrate that the pairing of spike trains elicits timing-dependent forms of LTP and LTD that are supported by a complex set of cellular mechanisms involving NMDARs and endocannabinoid activation of TRPV-like receptors.     

Reliability and validity of the kiddie mach scale in Chinese children

The present study examined the psychometric properties of a translated Chinese version of the Kiddie Mach Scale in a sample of Chinese students (N=787) ages 9 to 13 years (416 boys, 371 girls; M age= 11.3 yr., SD = 1.3). Results of confirmatory factor analysis showed a three-factor structure to be the most adequate model: Distrust, Lack of faith in human nature, and Dishonesty. These results are similar to the English version, but not the Greek version. The Chinese version exhibited weak internal consistency, but acceptable 4-week test-retest reliability. The Chinese version of the Kiddie Mach Scale was significantly associated with the Basic Empathy Scale. There was a sex effect on Kiddie Mach Scale scores with boys scoring higher on the Total scale and the Distrust subscale. Some items did not seem to function well in Chinese culture. More research will be needed to find items that represent, especially, distrust in Chinese settings.     

Sleep architecture in patients with fibromyalgia

The main objective of this work was to evaluate the characteristics of sleep in patients diagnosed with fibromyalgia syndrome. Sleep architecture in 32 patients with fibromyalgia and 20 healthy controls was evaluated. Following the recommendations of the International Federation of Clinical Neurophysiology, polysomnographies were conducted with fibromyalgia patients and the control subjects. The fibromyalgia patients showed alterations in cyclic organization of sleep and an increased number of periodic leg movements associated with cortical arousals. No significant differences were found in respiratory and oximetry variables or in alpha-delta sleep. The results support that fibromyalgia patients present an increase of superficial sleep at the expense of deep sleep and also an increase of periodic leg movements, which could have a pathogenic effect, facilitating the onset of the illness. Lastly, we discuss the results and propose some future lines of research.     

Basic numerical capacities and prevalence of developmental dyscalculia: the Havana Survey

The association of enumeration and number comparison capacities with arithmetical competence was examined in a large sample of children from 2nd to 9th grades. It was found that efficiency on numerical capacities predicted separately more than 25% of the variance in the individual differences on a timed arithmetical test, and this occurred for both younger and older learners. These capacities were also significant predictors of individual variations in an untimed curriculum-based math achievement test and on the teacher scores of math performance over developmental time. Based on these findings, these numerical capacities were used for estimating the prevalence and gender ratio of basic numerical deficits and developmental dyscalculia (DD) over the grade range defined above (N = 11,652 children). The extent to which DD affects the population with poor ability on calculation was also examined. For this purpose, the prevalence and gender ratio of arithmetical dysfluency (AD) were estimated in the same cohort. The estimated prevalence of DD was 3.4%, and the male:female ratio was 4:1. However, the prevalence of AD was almost 3 times as high (9.35%), and no gender differences were found (male:female ratio = 1.07:1). Basic numerical deficits affect 4.54% of school-age population and affect more boys than girls (2.4:1). The differences between the corresponding estimates were highly significant (α < .01). Based on these contrastive findings, it is concluded that DD, defined as a defective sense of numerosity, could be a distinctive disorder that affects only a portion of children with AD.     

Graph‐Framing Effects in Decision Making

This study manipulated the graphical representation of options by framing the physical characters in figures and found that preferences could be affected even when the words and numbers of the problem were constant. Based on attribute substitution theory and an equate‐to‐differentiate approach, we proposed a two‐process model of graph‐framing effects. In the first mental process, the graph‐editing process, the physical features (e.g., distance, size) represented in the graph are visually edited, and the perceived numerical difference between the options is judged based on its physical features. The second mental process, the preferential choice process, occurs by an equate‐to‐differentiate approach in which people seek to equate the difference between options on the dimension on which the difference is smaller, thus leaving the greater other‐dimensional difference to be the determinant of the final choice. Four experiments were tested for graph‐framing effects. Experiment 1 found a graph‐framing effect in coordinate graphs resting on the (de)compression of the scales employed in the figures. Experiment 2 revealed additional graph‐framing effects in other question scenarios and showed that preference changes were mediated by perceived numerical distances. Experiment 3 further confirmed the presence of graph‐framing effects in sector graphs similar to those found in coordinate ones. Experiment 4 suggested that such graph‐framing effects could be eliminated when logical processing (e.g., introducing a mathematical operation before a choice task) was encouraged. This paper discusses related research and a possible substrate basis for graph‐framing effects. Copyright © 2011 John Wiley & Sons, Ltd.     

HBV相关肝细胞癌综合治疗中抗病毒的作用

分析抗病毒治疗在乙型肝炎病毒相关肝细胞癌的综合治疗中所起的作用.随着肝细胞癌治疗模式的转变,目前认为抗HBV治疗是HCC综合治疗的重要组成部分,应针对患者进行个体化、优化的多学科综合治疗,选择合适的高效、低耐药、低副作用的抗病毒药物,才能达到提高患者生活质量和延长生存时间的目的.     

不同类型音乐对悲伤情绪舒缓作用的EEG研究

该研究采用EEG法探究音乐对悲伤情绪舒缓作用。选取中国古典、流行、摇滚及班得瑞音乐及悲伤影片。播放影片诱发悲伤情绪后,用音乐进行舒缓,同步采集脑电,分析得脑电功率谱(PS)及重心频率(GF)。结果表明,影片显著降低了GF及α频段PS;古典音乐GF最高,且诱发的α段PS最高,摇滚乐最低;脑对音乐加工的性别差异显著,半球差异不显著;主观体验悲伤度与α波PS显著负相关。所选音乐均具情绪舒缓作用,中国古典音乐最佳;α波PS,可作为反映悲伤-快乐情绪体验变化的脑电指标。     

布朗芬布伦纳从襁褓走向成熟的人类发展观

布朗芬布伦纳的思想在人类发展理论中占有着举足轻重的地位,这个一直处于演进之中的理论实现了人类发展观从静到动的转变,开创性的提出了一个全新的视角与理论框架.文章沿着历史的轨迹,完整记述了布朗芬布伦纳思想的起源与演进,重点关注了生态学视角中全新的人与环境关系、发展中人的概念和环境的概念,以及生物生态学模型中过程、人、环境、时间概念和相关应用中存在的问题.