Co-induction of long-term potentiation and long-term depression at a central synapse in the leech

Most studies of long-term potentiation (LTP) have focused on potentiation induced by the activation of postsynaptic NMDA receptors (NMDARs). However, it is now apparent that NMDAR-dependent signaling processes are not the only form of LTP operating in the brain [Malenka, R. C., & Bear, M. F. (2004). LTP and LTD: An embarrassment of riches. Neuron, 44, 5–21]. Previously, we have observed that LTP in leech central synapses made by the touch mechanosensory neurons onto the S interneuron was NMDAR-independent [Burrell, B. D., & Sahley, C. L. (2004). Multiple forms of long-term potentiation and long-term depression converge on a single interneuron in the leech CNS. Journal of Neuroscience, 24, 4011–4019]. Here we examine the cellular mechanisms mediating T-to-S (T → S) LTP and find that its induction requires activation of metabotropic glutamate receptors (mGluRs), voltage-dependent Ca²⁺ channels (VDCCs) and protein kinase C (PKC). Surprisingly, whenever LTP was pharmacologically inhibited, long-term depression (LTD) was observed at the tetanized synapse, indicating that LTP and LTD were activated at the same time in the same synaptic pathway. This co-induction of LTP and LTD likely plays an important role in activity-dependent regulation of synaptic transmission.     

应激对记忆影响的脑科学研究及其教育启示

大量脑科学的研究揭示,应激对与海马相关的陈述性记忆的调节主要通过应激激素,尤其是糖皮质激素的分泌而发生作用,而影响的方向取决于一些调节变量,包括糖皮质激素升高的水平以及记忆的不同阶段等。研究发现基底外侧杏仁核是糖皮质激素对记忆不同阶段产生差异性影响的关键部位。因此,在教育过程中,既要科学地认识应激对记忆的消极影响,又要有效利用应激对记忆产生的调节作用,来提高学生的学习效率。     

广东省城乡初中生元认知水平比较研究

研究采用自编问卷和访谈法对城乡初中生进行元认知水平的对比研究,结果表明：1）城乡初中生元认知水平总体差异显著,农村初中生的元认知水平总体低于城市初中生的元认知水平。2）城乡初中生在认知前元认知体验和认知中元认知知识维度上差异显著。认知前元认知知识、认知中元认知体验、认知后元认知知识、认知后元认知体验之间无显著性差异。建议加强教师和学生元认知训练,提高学生元认知水平。     

关于马基雅维利主义的道德心理研究

上世纪60～70年代,Christie创造了马基雅维利主义的心理学构念,而Exline,Geis和Bogart开创了关于马基雅维利主义的道德心理研究,后继研究者继承并不断完善他们的实验方法,探讨了马基雅维利主义与不道德行为(尤其是欺骗和逢迎)、道德判断(包括道德观和道德推理)、道德教育的关系。研究结果发现,尽管有证据证明马基雅维利主义与不道德行为存在密切关系,但两者是否是直接的因果关系仍存争议,不过多数学者一致认为马基雅维利主义者的不道德行为缘于其道德判断和道德教育,他们决策时将传统道德标准排除在决策标准体系之外,因此描述他们道德判断应采用"非道德"而不是"不道德"。     

童年期创伤对大学生抑郁的影响:早期适应不良图式和负性生活事件的作用

目的:考察早期适应不良图式、负性生活事件在童年期创伤与大学生抑郁间的影响机制。方法:采用童年期创伤问卷、Young图式问卷短版中文修订版、青少年生活事件量表及90项症状自评量表对1423名大学生进行调查,结果表明:(1)童年期创伤既可以直接正向预测大学生抑郁,也可以通过早期适应不良图式中的分离和拒绝、自主性及能力受损两大图式类别间接地正向预测大学生抑郁;(2)负性生活事件调节了早期适应不良图式在童年期创伤与抑郁间的中介作用     

Suicidal ideation among rural immigrant daughters-in-law with multi-roles as females,farmers and immigrants in China

Suicide is a major public health issue in China, and suicidal ideation is an important step in the suicidal process. The purpose of this study was to understand the prevalence and correlates of suicidal ideation among rural immigrant daughters-in-law with multi-role of female, farmer and immigrant in China. A total of 939 participants including 474 local daughters-in-law and 465 immigrant daughters-in-law were surveyed using the self-rating questionnaire. Demographic characteristics, depression, anxiety, impulsivity and suicidal ideation were assessed. Results indicated that the lifetime prevalence of suicidal ideation among rural immigrant daughters-in-law was 9.68%. Physical disability, domestic violence and negative events demonstrated statistical significance by suicidal ideation (p < .05), and participants with suicidal ideation had higher scores of depression, anxiety and impulsiveness in the univariate analysis. Multivariate logistic regression showed that physical disability (OR = 7.43, 95%CI: 2.84–19.46), domestic violence (OR = 2.65, 95%CI: 1.02–6.88), depression (OR = 1.07, 95%CI: 1.01–1.12), impulsiveness (OR = 1.04, 95%CI: 1.01–1.08) and motor impulsiveness (OR = 1.07, 95%CI: 1.01–1.14) were significantly associated with suicidal ideation. Suicidal ideation is an issue that can’t be ignored among rural immigrant daughters-in-law. And the findings should be considered for the intervention of the suicide among the rural immigrant daughters-in-law.     

An information-processing model of the BOLD response in symbol manipulation tasks

Two imaging experiments were performed—one involving an algebraic transformation task studied by Anderson, Reder, and Lebiere (1996) and the other an abstraction symbol manipulation task studied by Blessing and Anderson (1996). ACT-R models exist that predict the latency patterns in these tasks. These models require activity in an imaginal buffer to represent changes to the problem representation, in a retrieval buffer to hold information from declarative memory, and in a manual buffer to hold information about motor behavior. A general theory is described about how to map activity in these buffers onto the fMRI blood oxygen level dependent (BOLD) response. This theory claims that the BOLD response is integrated over the duration that a buffer is active and can be used to predict the observed BOLD function. Activity in the imaginal buffer is shown to predict the BOLD response in a left posterior parietal region; activity in the retrieval buffer is shown to predict the BOLD response in a left prefrontal region; and activity in the manual buffer is shown to predict activity in a motor region. More generally, this article shows how to map a large class of information-processing theories (not just ACT-R) onto the BOLD response and provides a precise interpretation of the cognitive significance of the BOLD response.     

中国军人心理健康状况的元分析

研究的目的在于深入探讨军人的心理健康状态。通过文献查阅收集了77篇用SCL-90作为测评工具的关于军人心理健康状况的研究,样本量为56164人,根据被试情况把这些研究分为两组,一组为军事应激条件下的军人,另一组为非军事应激条件下的军人,分别对两组研究进行了元分析。研究发现非军事应激条件下军人的心理健康水平与军人常模差不多;军事应激条件下军人的心理健康水平在应激前高于军人常模,应激中低于军人常模,应激后与军人常模差不多。其中城镇驻军的心理健康水平高于高原驻军,高于边防驻军;应激中的心理健康水平低于应激后,低于应激前;地域、人员类别以及应激水平等因素对军人SCL-90得分有显著影响。敏感性分析和发表偏倚显示本研究的稳定性较好,没有发表偏倚。表明中国军人的心理健康状况并非很差;与金华等的地方成人常模和蔡心培的国家军用标准相比,王焕林19662人的军人常模更适合于做军人的比较标准;地域、人员类别以及应激水平等因素对SCL-90得分有显著影响     

医学人文素质教育与小班化教学

中国医学人文教育正处于起步、探索阶段,课堂教学是主要渠道和途径,而目前各校的医学人文教育采取的大班课教学方式影响了教学效果.从医学人文教育的理念和教育规律出发,并借鉴他国的经验,小班化教学应是落实人文教育的实效性一个中心环节.