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251.
Kuo YM Liang KC Chen HH Cherng CG Lee HT Lin Y Huang AM Liao RM Yu L 《Neurobiology of learning and memory》2007,87(1):93-100
Context-induced drug craving and continuous drug use manifest the critical roles of specific memory episodes associated with the drug use experiences. Drug-induced conditioned place preference (CPP) in C57BL/6J mouse model, in this regard, is an appropriate behavioral paradigm to study such drug use-associated memories. Requirement of protein synthesis in various forms of long-term memory formation and storage has been phylogenetically demonstrated. This study was undertaken to study the requirement of protein synthesis in the learning and memory aspect of the conditioned place preference induced by cocaine and methamphetamine, two abused drugs of choice in local area. Since pCREB has been documented as a candidate substrate for mediating the drug-induced neuroadaptation, the pCREB level in hippocampus, nucleus accumbens, and prefrontal cortex was examined for its potential participation in the formation of CPP caused by these psychostimulants. We found that cocaine (2.5 and 5.0 mg/kg/dose)-induced CPP was abolished by the pretreatment of anisomycin (50 mg/kg/dose), a protein synthesis inhibitor, whereas methamphetamine (0.5 or 1.0 mg/kg/dose)-induced CPP was not affected by the anisomycin pretreatment. Likewise, cocaine-induced CPP was mitigated by another protein synthesis inhibitor, cycloheximide (15 mg/kg/injection) pretreatment, whereas methamphetamine-induced CPP remained intact by such pretreatment. Moreover, anisomycin treatment 2h after each drug-place pairing disrupted the cocaine-induced CPP, whereas the same treatment did not affect methamphetamine-induced CPP. An increase of accumbal pCREB level was found to associate with the learning phase of cocaine, but not with the learning phase of methamphetamine. We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP. Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins. 相似文献
252.
1968年“五月风暴”不仅早已成为历史(包括思想史)的徽章与历史学的记载对象,而且体现了一种时代精神。可见,回答“什么是五月风暴?”这个问题当然是哲学沉思的一项任务。如果说,启蒙运动的一份珍贵遗产是促使人们对现代性的深刻反思和强力推动,那么,五月风暴则把后现代性推向了一个前所未有的高度,并且秉承启蒙运动发展起来的自由与民主传统。与“启蒙运动”一样,五月风暴能促使一大批法国公共知识分子思考“今日”,激活哲学问题以给出关于哲学的崭新定义,与结构主义思潮产生错综复杂的关系。因此,通过对五月风暴的哲学沉思,我们学会如何理解“我们自身”的现实性和当前危机。 相似文献
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时间压力是决策的重要因素.研究引入时间压力变量(高时间压力、非时间压力),探索了时间压力对风险决策的框架效应的影响.结果显示:(1)时间压力弱化了风险决策的框架效应;(2)时间压力情境下的框架效应是一个精细加工的过程. 相似文献
258.
余治平 《Frontiers of Philosophy in China》2009,4(4):511-523
Independent narration in Chinese philosophy has gone through the process of interpretation, critical differentiation, dialogue,
and original thought, and so is a creative activity that surpasses the conjunctive pattern of universality and particularity.
In modern Confucian studies, there has always been a tension between philosophical and historical explanations, which suggests
a tension between ecumenical and indigenous experiences. Critical differentiation itself only has methodological significance,
and is not a goal in itself. China’s development and strength has encouraged China to engage in philosophical dialogue with
the West. It is the task and direction of future philosophical creativity to face the contemporary existence, re-construct
Confucianism’s relationship with modern life, and respond in a metaphysical and positive manner to the challenges imposed
by modernity. 相似文献
259.
从GVC走向NVC:长三角一体化与产业升级 总被引:3,自引:0,他引:3
融入全球价值链对我国区域间产业部门的联系产生了弱化效应,对区域实体经济的一体化发展产生了不利的影响.国内价值链的构建,既是长三角制造企业摆脱单一地依赖全球价值链的出口导向、实现可持续升级和可持续发展的重要举措之一,也是促进长三角区域经济进一步一体化的动力所在. 相似文献
260.