关于我国医患会话研究的思考

医患会话分析是一种尊重语言事实的社会学实证研究方法.我国研究者主要从医患会话的语言结构组合特点和基本特征;医患合作模式、特点和原则以及医患会话信息传递方式等方面进行了分析.目前研究中存在语料的覆盖面、典型性不够,分析语言现象与本质的逻辑不严密,语料属性判断标准不统一,研究目标不明确等主要问题.     

Phosphorylated nerve growth factor-induced clone B (NGFI-B) translocates from the nucleus to mitochondria of stressed rat cardiomyocytes and induces apoptosis

Stress induces cardiac dysfunction and cardiomyocyte injury, and while current data indicate that mitochondria play a key role in this process, the mechanisms remain unknown. In this study, we found that in rats, restraint stress induced nerve growth factor-induced clone B (NGFI-B) translocation from the nucleus to mitochondria in cardiomyocytes. This translocation promoted cytochrome c release from mitochondria to the cytoplasm, which ultimately resulted in cardiomyocyte apoptosis. We also found that stress induced oversecretion of glucocorticoids and activated the protein kinase A (PKA) pathway in cardiomyocytes. Enhanced PKA activity increased NGFI-B serine phosphorylation, which caused NGFI-B to translocate from the nucleus to mitochondria. Moreover, a PKA peptide inhibitor blocked NGFI-B serine phosphorylation and translocation. Our data demonstrate that stress affects cardiomyocytes by inducing NGFI-B mitochondrial translocation via serine phosphorylation, which in turn initiates mitochondrial-mediated apoptosis.     

青少年留守经历对网络成瘾的影响:病理性互联网使用的认知行为模型视角

基于病理性互联网使用的认知行为模型,本研究考察青少年留守经历对网络成瘾的影响,并检验非适应性认知的中介作用和粗暴养育的调节作用。以525名中学生为被试,采用非适应性认知问卷、粗暴养育问卷和网络成瘾问卷进行测试,结果发现:(1)有留守经历的个体非适应性认知和网络成瘾的程度更高,而且非适应性认知越强,网络成瘾程度越高;(2)留守经历通过非适应性认知的中介作用影响网络成瘾;(3)留守经历对非适应性认知的影响受到粗暴养育的调节。具体而言,经历较多粗暴养育的青少年,留守经历会增加非适应性认知;但是对于经历较少粗暴养育的青少年,留守经历不会对非适应性认知产生影响。本研究的结果表明,青少年留守经历会增强非适应性认知,进而增加网络成瘾的倾向。但是,如果青少年家庭中粗暴养育程度较低,青少年留守经历对非适应性认知的影响就会消失。     

群体购买情境下冲动性购买影响研究：解释水平视角

本研究基于解释水平理论视角,检验了消费者在群体购买情境中的冲动性购买行为.研究1采用2（解释水平：高vs.低）＆#215;2（自我建构：独立vs.互依）组间因子设计,用来检验解释水平是否调节自我建构类型对冲动性购买的影响;研究2采用2（解释水平：高vs.低）＆#215;2（认知模式：感知vs.模拟）组间因子设计,检验认知模式和解释水平对冲动性购买的联合影响.实验结果表明：群体购买情境下,消费者自我建构类别不同,冲动性购买意愿也不同,且受到解释水平的调节影响;群体购买情境下,消费者对他人认知模式的不同,对自身冲动性购买的影响也不同,解释水平在其中也起到了调节作用.     

中小学生欺负者归因特点的研究

本研究以归因理论为依据,采用自编的中小学生欺负者归因量表对3-9年级学生施测,以考察中小学生欺负者归因的基本特点。结果发现:(1)中小学生较多地从IUC上知觉欺负者的欺负行为,较少从ESU上知觉该行为;(2)在ISC、ISU、IUC、EUC、EUU这五个原因上存在性别差异;(3)除ESU外的七项原因的知觉上存在组别差异;(4)对八项原因的知觉上均存在显著性年级差异;(5)独生子女因素对欺负者归因不存在显著性影响。     

恢复性环境研究:理论、方法与进展

近十年来,"恢复性环境"成为环境心理学研究的热点。目前,从恢复结果的角度,注意恢复理论和心理进化理论认为,恢复性环境是指有助于人们更好地从心理疲劳以及和压力相伴随的消极情绪、生理反应中恢复过来的环境。对该环境的研究主要采用量表法和实验法,研究结果涉及恢复结果、影响恢复的因素、恢复和偏好的关系、恢复性环境的眼动特征以及临床应用。今后应该更侧重对恢复性环境理论和研究设计的进一步完善、量表的效度验证,并加强研究成果的具体应用。     

Altered topological patterns of large-scale brain functional networks during passive hyperthermia

In this study, we simulated environmental heat exposure to 18 participants, and obtained functional magnetic resonance image (fMRI) data during resting state. Brain functional networks were constructed over a wide range of sparsity threshold according to a prior atlas dividing the whole cerebrum into 90 regions. Results of graph theoretical approaches showed that although brain networks in both normal and hyperthermia conditions exhibited economical small-world property, significant alterations in both global and nodal network metrics were demonstrated during hyperthermia. Specifically, a lower clustering coefficient, maintained shortest path length, a lower small-worldness, a lower mean local efficiency were found, indicating a tendency shift to a randomized network. Additionally, significant alterations in nodal efficiency were found in bilateral gyrus rectus, bilateral parahippocampal gyrus, bilateral insula, right caudate nucleus, bilateral putamen, left temporal pole of middle temporal gyrus, right inferior temporal gyrus. In consideration of physiological system changes, we found that the alterations of normalized clustering coefficient, small-worldness, mean normalized local efficiency were significantly correlated with the rectal temperature alteration, but failed to obtain significant correlations with the weight loss. More importantly, behavioral attention network test (ANT) after MRI scanning showed that the ANT effects were altered and correlated with the alterations of some global metrics (normalized shortest path length and normalized global efficiency) and prefrontal nodal efficiency (right dorsolateral superior frontal gyrus, right middle frontal gyrus and left orbital inferior frontal gyrus), implying behavioral deficits in executive control effects and maintained alerting and orienting effects during passive hyperthermia. The present study provided the first evidence for human brain functional disorder during passive hyperthermia according to graph theoretical analysis using resting-state fMRI.     

英国辞世教育见闻

英国是现代临终关怀的发源地,经过多年努力,逐渐摸索出一套有效并广为借鉴和效仿的辞世教育方法。圣克里斯多夫宁养院主要通过“学校计划”对中、小学、医学院校学生进行教育培训,通过音乐会、图书馆和书店、临终事务联盟、预先照顾计划等多种形式进行公众教育,带动了整个英国的辞世教育。医学院校医学生的辞世教育是以当地的临终关怀专业机构...     

两种视觉特征提示对儿童错误记忆发展的影响

采用DRM研究范式,实验一使用示意图提示,探讨特异性视觉特征对于8岁、10岁和12岁儿童错误记忆的影响及其随年龄而产生的变化;实验二使用位置提示,探讨非特异性视觉特征对8岁、10岁和12岁儿童错误记忆的影响及其随年龄增长而产生的变化。实验结果说明:(1)特异性视觉特征提示会显著减少错误记忆,而非特异性视觉提示则会显著增加错误记忆。(2)8～12岁儿童错误记忆随着年龄的增长而增长,这可能是由于儿童随年龄增长不断地发展其形成要义痕迹表征和要义连接的能力所致。(3)特异性视觉特征提示对8岁儿童错误记忆的影响不显著,对10岁和12岁儿童有显著削弱作用,但这种影响在10岁和12岁儿童间没有显著性地增长。(4)非特异性视觉特征提示对8岁儿童错误记忆不产生显著影响,对10岁和12岁儿童有显著的增强作用,且这种影响从8岁至12岁呈显著性增长。     

脑血管病治疗现状及评析

我国正处于人口老龄化、脑血管病患者迅速增加的时期,针对各地千差万别的医疗水平,系统梳理和总结国内外脑血管病有关指南及规范的基础上,强调了脑血管病的预防的重要性,并提出我国数种常见脑血管病的治疗策略选择的意见及建议.