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41.
阿尔茨海默病(AD)是常见的中枢神经系统变性疾病,是痴呆最常见的病因,发病率高.病理特征为老年斑及神经元纤维缠结.AD的确诊有赖病理学,临床诊断极其耗时.由于尚无准确的早期诊断方法,常使AD患者错过早期治疗的时机,这成为制约有效防控AD的瓶颈问题.因此寻找高敏感性、特异性、无创性的生物学标志物对AD的早期诊断至关重要.本文仅将目前较为广泛研究的生物学标志物及其研究现状作一概述.分别对脑脊液、血液、尿液及唾液中的AD标志物作逐一介绍. 相似文献
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43.
Qiufang Fu Guangyu Bin Zoltan Dienes Xiaolan Fu Xiaorong Gao 《Consciousness and cognition》2013,22(1):22-34
This paper investigated how implicit and explicit knowledge is reflected in event-related potentials (ERPs) in sequence learning. ERPs were recorded during a serial reaction time task. The results showed that there were greater RT benefits for standard compared with deviant stimuli later than early on, indicating sequence learning. After training, more standard triplets were generated under inclusion than exclusion tests and more standard triplets under exclusion than chance level, indicating that participants acquired both explicit and implicit knowledge. However, deviant targets elicited enhanced N2 and P3 components for targets with explicit knowledge but a larger N2 effect for targets with implicit knowledge, revealing that implicit knowledge expresses itself in relatively early components (N2) and explicit knowledge in additional P3 components. The results help resolve current debate about the neural substrates supporting implicit and explicit learning. 相似文献
44.
Jian‐Bin Li Yan‐Gang Nie Min‐Xia Zeng Meghan Huntoon Jessi L. Smith 《International journal of psychology》2013,48(6):1303-1312
Past research has consistently found that people are likely to do worse on high‐level cognitive tasks after exerting self‐control on previous actions. However, little has been unraveled about to what extent ego depletion affects subsequent prospective memory. Drawing upon the self‐control strength model and the relationship between self‐control resources and executive control, this study proposes that the initial actions of self‐control may undermine subsequent event‐based prospective memory (EBPM). Ego depletion was manipulated through watching a video requiring visual attention (Experiment 1) or completing an incongruent Stroop task (Experiment 2). Participants were then tested on EBPM embedded in an ongoing task. As predicted, the results showed that after ruling out possible intervening variables (e.g. mood, focal and nonfocal cues, and characteristics of ongoing task and ego depletion task), participants in the high‐depletion condition performed significantly worse on EBPM than those in the low‐depletion condition. The results suggested that the effect of ego depletion on EBPM was mainly due to an impaired prospective component rather than to a retrospective component. 相似文献
45.
The purpose of this study was to investigate the differences of knee concentric and eccentric strength and impact related knee biomechanics between jumpers and non-jumpers during step-off landing tasks. Ten male college swimming athletes (non-jumpers) and 10 track and volleyball athletes (jumpers) were recruited to participate in two test sessions: a muscle strength testing session of concentric and eccentric extension for dominant knee joint at 60 °/s and 180 °/s and a landing testing session. The participants performed five trials of step-off landing in each of four conditions: soft and stiff landing from 0.4 m and 0.6 m landing heights. The three-dimensional kinematics and ground reaction force were recorded simultaneously during step-off landing conditions. The results showed that the jumpers had significantly greater peak knee eccentric extension and concentric flexion torques compared to the non-jumpers. No significant group effects were found for peak vertical ground reaction force and knee range of motion during landing. The jumpers had significantly greater knee contact flexion angle, maximum knee flexion angle and initial knee extension moment compared to the non-jumpers. These results suggest that these athletes adopted a favorable impact attenuation strategy that is related to the greater knee eccentric muscle strength and training. 相似文献
46.
Wei‐Bin Zhang 《World Futures: Journal of General Evolution》2013,69(4):209-223
The purpose of this study is to discuss the dynamic interdependence of knowledge and economic growth. We show that the traditional economics, which treats knowledge as parameters and is mainly developed within linearized, stable and static frameworks can hardly explain the modern economic complexity. We argue that it is necessary to treat creativity, learning and knowledge utilization as endogenous dynamic processes of social and economic evolution. To handle with the complicated dynamic interdependence of wealth and knowledge accumulation, we need to apply genuine nonlinear dynamic theory. In particular, we discuss possible benefits of government's intervention in education and science to the society when the social and economic evolution is characterized of nonlinearity, instability and multi‐equilibria. 相似文献
47.
Xianta Jiang Geoffrey Tien Da Huang Bin Zheng M. Stella Atkins 《Behavior research methods》2013,45(3):656-663
Blinks are related to several emotional states, and the present report describes a simple, reliable way to measure blinks from the video stream of an eye obtained during eyetracking, where the source of the eye video is a video camera attached to a head-mounted eyetracker. Computer vision techniques are employed to determine the moments that a blink starts and ends, for the purpose of calculating blink frequency and duration. The video is first processed to show blocks of eyelid and pupil movements, and is then analyzed for blink starts and ends. The moment of a blink start is reported when the eyelid starts to move quickly, exceeding a predetermined threshold. The end of a blink arises when the pupil size increases by less than a separate threshold. We observed several different blink patterns from different subjects, and our algorithm was designed to work for all of these patterns. We evaluated our algorithm by manually measuring the true blinks of five different subjects while they were eyetracked. To test the sensitivity and specificity of the algorithm, we employed a series of threshold values to plot the receiver operating characteristic curves. Using the best thresholds, we achieved excellent sensitivity (>90 %) and specificity (>99 %) over the five subjects. Potential applications of this research include real-time, nonintrusive, continuous and automated measurements of mental workload and other emotional states related to blink rates and durations. 相似文献
48.
生活充满抉择,由于知识经验的局限,人们常需寻求他人建议,抑或直接请他人代己决策.诸多研究探讨了自我决策、向他人建议,以及代他人决策之间的差异.探究这种差异的动因之一在于考察何种条件下的决策更优或更“理性”.以往研究表明,自我决策或他人决策(向他人建议或代他人决策)均有可能更易违背理性决策原则,隐含着他人决策优于自我决策的“当局者迷,旁观者清”这一传统智慧有一定的边界条件.研究者一般从认知(建构水平理论)、情绪(类型和卷入度),以及动机(调节聚焦理论)三种视角对自我-他人决策差异进行解释.本文作者提出基于理由的决策(reason-based account)假设来解释自我-他人决策在理性程度上的差异.未来研究可从决策过程及脑机制上深入考察自我-他人决策差异及其机制. 相似文献
49.
大鱼小池效应(Big Fish Little Pond Effect)是解释不同教育情境中学生自我概念水平的一个特定概念,Marsh将其定义为:能力同等的学生,在平均成绩较高的学校或班级里的学业自我概念较低,而在平均成绩较低的学校或班级则学业自我概念会较高。大鱼小池效应包括学生采用概括他人和特定他人的比较标准所分别产生的同化效应和对比效应,社会比较对学业自我概念形成具有特定影响。大鱼小池效应的未来研究可以从研究方法的改进、调节变量的控制和跨文化比较等方面拓展。 相似文献
50.
采取整群抽样的方法,对成都及重庆两地591名流动儿童和272名城市儿童进行问卷调查,考察流动儿童疏离感的特点及其与应对方式和学校态度的关系。结果发现:(1)流动儿童疏离感各维度显著高于城市儿童;流动初中生的疏离感显著高于流动小学生,且男生的疏离感显著高于女生;(2)流动儿童疏离感的三个维度之间存在显著差异,其中社会疏离感最高,其次是环境疏离感,人际疏离感最低;(3)流动儿童疏离感对学校喜欢有显著的负向影响,而对学校回避有显著的正向影响;应对方式在流动儿童疏离感对学校态度的影响中起着部分中介作用。 相似文献