Is the use of sentient animals in basic research justifiable?

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities.     

Outcomes of training in supervision: Randomised controlled trial

There is little controlled research on the impact of supervisor training on supervision. The current study examined the effects of supervision training in a sample of 46 supervisor–supervisee pairs of mental health practitioners. It compared Immediate 2‐day workshop training of the pair, a wait‐list control in which workshop training was delayed 3 months, and a condition in which supervisors were trained 3 months before their partners (Split). Benefits of Immediate training were restricted to supervisors reporting fully specified agreements, and to reduction of some perceived problems. Self‐efficacy in providing effective supervision fell in the Split condition, relative to the other conditions. Across conditions in general there was a fall from baseline to post‐test assessment in the proportion of sessions where recommended supervision strategies were used, perhaps partly because the controlled trial extended across the summer vacation period. Results are consistent with other observations of the limited impact of workshop training on practice.     

Characterizing the motivational orientation of students in higher education: A naturalistic study in three Hong Kong universities

Background . Consideration of motivation in higher education has often been drawn upon theories and research that were based upon school or workplace studies. Aims . This paper reports an open naturalistic study to better characterize the motivational orientation of students in higher education. Method . Open semi‐structured individual interviews were conducted with 36 students from three universities in Hong Kong. The analysis used an exploratory grounded theory approach. Results . Motivation was characterized as a framework with six continua with positive and negative poles. On enrolment, students had positions on the six facets of motivation, which shifted as they progressed through their degree, according to perceptions of their teaching and learning environment. The positive poles of the six continua were given labels: compliance, individual goal setting, interest, career, sense of belonging and university lifestyle. Conclusion . The formulation of motivational orientation is consistent with contemporary social cognitive theories of motivation in that it has been characterized as a multifaceted phenomenon, with students expressing context‐dependent multiple motives.     

Two routes for activation in the priming of categorical coordinates

The authors operationalized category priming as participants' recognition facilitation of nonstudied, low semantically similar exemplars by studied exemplars in a category. The existing literature either does not examine the effect of studied exemplars on nonstudied exemplars in a category or fails to show an appreciable amount of category priming. In 2 experiments, the authors demonstrated a unique process to account for the category priming effect and distinguish it from the semantic priming effect, facilitation of semantically similar exemplars, in the context of a category. In Experiment 1A, the authors used a multidimensional scaling technique to examine participants' internal structure of different categories. In Experiment 1B, the authors used a lexical decision task that used these internal structures to show that semantic encoding of category exemplars causes activation of existing category knowledge in memory. Consequently, participants easily recognized nonstudied, low semantically similar exemplars in a category. However, recognition facilitation between high semantically similar exemplars did not require category knowledge activation.     

All in the mind's eye? Anger rumination and reappraisal

Research on rumination has demonstrated that compared with distraction, rumination intensifies and prolongs negative emotion. However, rumination and distraction differ both in what one thinks about and how one thinks about it. Do the negative outcomes of rumination result from how people think about negative events or simply that they think about them at all? To address this question, participants in 2 studies recalled a recent anger-provoking event and then thought about it in 1 of 2 ways: by ruminating or by reappraising. The authors examined the impact of these strategies on subsequent ratings of anger experience (Study 1) as well as on perseverative thinking and physiological responding over time (Study 2). Relative to reappraisal, rumination led to greater anger experience, more cognitive perseveration, and greater sympathetic nervous system activation. These findings provide compelling new evidence that how one thinks about an emotional event can shape the emotional response one has.     

Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia

Exposure to high altitude is known to cause impairment in cognitive functions in sojourners. The molecular events leading to this behavioral manifestation, however, still remain an enigma. The present study aims at exploring the nature of memory impairment occurring on chronic exposure to hypobaric hypoxia and the possible role of glutamate in mediating it. Increased ionotropic receptor stimulation by glutamate under hypobaric hypoxic conditions could lead to calcium mediated excitotoxic cell death resulting in impaired cognitive functions. Since glutamate is cleared from the synapse by the Glial Glutamate Transporter, upregulation of the transporter can be a good strategy in preventing excitotoxic cell death. Considering previous reports on upregulation of the expression of Glial Glutamate Transporter on ceftriaxone administration, the therapeutic potential of ceftriaxone in ameliorating hypobaric hypoxia induced memory impairment was investigated in male Sprague Dawley rats. Exposure to hypobaric hypoxia equivalent to an altitude of 7600 m for 14 days lead to oxidative stress, chromatin condensation and neuronal degeneration in the hippocampus. This was accompanied by delayed memory retrieval as evident from increased latency and pathlength in Morris Water Maze. Administration of ceftriaxone at a dose of 200 mg/kg for 7 days and 14 days during the exposure on the other hand improved the performance of rats in the water maze along with decreased oxidative stress and enhanced neuronal survival when compared to hypoxic group without drug administration. An increased expression of Glial Glutamate Transporter was also observed following drug administration indicating faster clearance of glutamate from the synapse. The present study not only brings to light the effect of longer duration of exposure to hypobaric hypoxia on the memory functions, but also indicates the pivotal role played by glutamate in mediating excitotoxic neuronal degeneration at high altitude. The therapeutic potential of ceftriaxone in providing neuroprotection in excitotoxic conditions by increasing Glial Glutamate Transporter expression and thereby enhancing glutamate uptake from the synapse has also been explored.     

全球帝国主义与重构的后现代主义

现代文化和政治已经导致了全球帝国主义,即一种通过一个国家来创建一个无所不包的帝国的尝试。为了战胜这种全球帝国主义,需要从现代世界秩序转向一种后现代世界秩序,其中,以主权为基础的民族国家的无政府秩序将被全球民主所取代。怀特海式的重构的后现代主义为后现代政治的双重任务(抵抗全球帝国主义和建立全球民主)提供了各种文化资源。     

Civic Knowledge of High School Students in Israel: Personal and Contextual Determinants

Past research on civic education suggests that students' performance is largely influenced by individual socioeconomic background and motivational factors. There has been little attention to the effects of school and classroom ideological and social attributes, such as the socioeconomic make-up of the school or classroom, or how interested in politics are a student's classmates. The results of the present study support the contention that contextual effects play a vital role in determining students' civic knowledge scores. Analysis of Israeli 11^th graders' performance on the International Association for the Evaluation of Educational Achievement (IEA) civic knowledge test shows that while individual backgrounds and motivations play a significant role, school and classroom contexts greatly contribute to civic knowledge acquisition.