Extinction of conditioned inhibition through nonreinforced presentation of the inhibitor

In previous studies that have tried to extinguish conditioned inhibition through nonreinforced presentations of the inhibitor, researchers have repeatedly failed to find evidence for such extinction. The present study revealed that extinction can be achieved through nonreinforcement of the inhibitor, depending on properties of the reinforcer. In a human causal learning experiment, we found complete extinction in a scenario in which the reinforcer could take on negative values. Thereby, this scenario reflected the assumed symmetrical continuum on which associative strength can vary, according to the Rescorla-Wagner theory of associative learning. In contrast to this, the inhibitory cue retained its inhibitory potential in another condition, in which the scenario did not allow negative values of the reinforcer. nt]mis|Klaus G. Melchers has previously published under the surname “Lober.” Susann Wolff is now working at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, Germany     

Impairment of single-trial memory formation by oral methylphenidate in the rat

High synaptic concentrations of dopamine and/or norepinephrine can impair the working memory function of the prefrontal cortex and impede attention and learning. Methylphenidate, a dopamine and norepinephrine transporter blocker known to facilitate these cognitive processes at low doses, was hypothesized to interfere with memory storage at doses that may raise concentrations of these neurotransmitters to systemically disruptive levels. In the present experiments, a dose of 10.0mg/kg of this drug was administered to female and male Long-Evans rats using a novel oral administration procedure designed to model the normal mode of delivery to humans. It was found to interfere with single-trial memory acquisition in a delayed object recognition test, a spontaneous learning task that involves no appetitive or aversive motivator. The time that the rats spent in overt exploration of the to-be-remembered objects during the acquisition trial was not affected, suggesting that the drug may have impaired processes of memory formation independently of interference with attention.     

Responsible conduct in research

Science is not taken for granted any longer. Society, politics and the media pose critical questions tending to censorship or at least control of science. How does science respond? It cannot exist and develop without freedom, but this does not mean freedom to amass knowledge and apply technological applications at any price and without restrictions. Science should be autonomous, but is not value-free. A distintion is made between external and internal social/ethical problems. The former refer to questions of the social/ethical context and consequences of scientific research, and the latter to the rules of ‘good practice’ and scientific integrity. The role of academies of science, and of associations of such academies (e.g. All European Academies (ALLEA)) in developing codes of good scientific practice and fostering a proper sense of scientific values and standards is further discussed.     

Consensus and normative validity 1

A weak and a strong version of discourse theory can be distinguished. In the strong version the only source of normative validity in the nonspecific sense is rational consensus, where all parties concerned accept a norm for the same reasons, which are rationally convincing in the same way for all. In the weak version both rational and overlapping consensus can be sources of validity in the nonspecific sense. It is argued that the weak version is the more adequate, since it can accommodate cases which the strong version cannot, and which it is unreasonable to view as cases of compromise. Discourse theory needs a weaker general discourse principle and a more flexible notion of normative consensus than is found in Habermas's Between Facts and Norms (1996).     

Construct Validity of the Social Physique Anxiety Scale in a French Adolescent Sample

The present study explored the validity of constriction as an indicator of depression. Twenty-five patients displaying constriction in their Bender records and 25 patients not showing this indicator were compared with regard to MMPI Depression scores. A significant difference was found between D scores of these two groups (p<.05), supporting the validity of the indicator as an index of depression. Constriction was found to be infrequent, occurring in only 5.5% of the patient records. Although the indicator seems to be of some value as an indicator of depression its utility is lessened due its low rate of occurrence.     

„Es waren ja fast alle weggegangen“

The complex and partly disputed history of German psychoanalysis during the Third Reich has been thoroughly investigated to date. There are various stages of historical analysis which are distinguished by differing discourses that are presented as part of this work. The first stage of historical analysis was characterized by conflicts within the German psychoanalytical societies and marked by two antagonistic narratives about the transformation of German psychoanalysis during the Third Reich. This study investigated which discourses on the history of German psychoanalysis were integrated into the professional biographies of the first generation of post-war psychoanalysts. In this study 23 narrative interviews were conducted with psychoanalysts who where born before 1st January 1937 focusing on the professional biography and the results were analyzed. The interviewees stressed the ‘damage’ to German psychoanalysis in general and on their training in particular. The ‘damage’ was described as an uncontrollable result of National Socialism and the structural and theoretical changes that were connected to it whereby its effects continued to impact on post-war psychoanalysis. Especially the discourses of the first stage of historical analysis appear to have been integrated into professional biographies and are still having an impact on the interpretation of history for the post-war generation to this day. The history of psychoanalysis is presented as a narrative of ‘rescue’ or ‘liquidation’ of psychoanalysis during the Third Reich depending on the professional identity of the psychoanalysts.     

Epidemiologie psychischer Störungen

The discipline of epidemiology not only contributes to knowledge regarding the distribution and prevalence of mental disorders but also to a better understanding of their causes and consequences. This article focuses on the prevalence and disease burden. Epidemiological studies show that mental disorders are more common than previously thought and that they are associated with a particularly high societal burden. Costs of illness are higher in mental disorders compared to many widespread somatic conditions because of their high prevalence, chronic course, young age of first onset and the profile of disability. The extent of inability to work due to mental disorders is rising steadily although a general decline in absenteeism has been observed across other disease types. This raises the question of whether mental disorders have increased recently. Furthermore, the general need for treatment is discussed as well as the corresponding mental health care options. Finally, it has been found that, despite the quantitatively relatively well-developed health care system in Germany, there are still signs of a significant undertreatment in the field of psychotherapy.     

Posttraumatische Belastungsstörung

There are some problems concerning the concepts of trauma-related disorders and especially the category of posttraumatic stress disorder (PTSD) with respect to classification, diagnosis and epidemiological findings, which can only be understood within the historical framework of the development. Even current diagnostic systems, such as the diagnostic and statistical manual of mental disorders version 4 (DSM-IV) and the international classification of diseases version 10 (ICD-10) differ in the classification of these disorders which led to higher prevalence rates being achieved with ICD-10. The diagnostic algorithms have been opened to included subsyndromal PTSD as well as complex PTSD including more severe psychiatric disorders.