Repeated-measures contrasts for "multiple-pattern" hypotheses

Contrast analysis of repeated-measures data generally focuses on hypotheses when only 1 pattern of results is of theoretical interest. This article articulates a framework for contrast analysis in repeated-measures contexts in which researchers have hypotheses relevant to 1 potential pattern or multiple potential patterns of results. For example, a researcher might ask whether participants exhibit a pattern of (a) immediate symptom reduction or (b) delayed symptom reduction. Alternatively, the researcher might ask whether 2 or more groups exhibit 2 or more patterns to differing degrees. Building on the familiar logic and computational procedures for 1-pattern hypotheses, the authors present a contrast analysis framework that integrates analysis of 1-pattern and multiple-pattern hypotheses and accommodates 1 group or multiple groups of participants.     

Methylphenidate-induced obsessive-compulsive symptoms in an elderly man

An 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminished over several weeks when methylphenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder. It appears that methylphenidate precipitated the patient's pathological behavior.     

Substance P antagonists: meet the new drugs,same as the old drugs? Insights from transgenic animal models

Antidepressants that primarily target the reuptake of monoamines have been highly successful treatments. However, therapies with these drugs still have several drawbacks, namely severe side effects, delays in the onset of action, and a significant percentage of non-responders. Recently, non-peptidic antagonists of the neurokinin 1 receptor, or substance P antagonists, have emerged as a novel class of drugs with antidepressant efficacy that is comparable to current drugs, but a potentially reduced side effect profile. This review summarizes the pre-clinical evidence derived from pharmacological and transgenic animal studies that suggests an important role for the substance P/neurokinin 1 system in anxiety and depression. Also, potential mechanisms by which substance P antagonists may produce their therapeutic effects are discussed.     

Consequences of Children's Exposure to Community Violence

Much has been learned over the past decade about the way children respond to experiences of violence in their community. The goal of this paper is to review what is known about the effects of community violence on children's development. In addition to main effects, factors that mediate these effects, as well as factors that moderate children's response to community violence are discussed. Special attention is paid to developmental differences in children's responses to community violence and the factors that may promote resilient functioning.     

The intelligent brain in conflict

Can individual differences in general reasoning ability be reduced to an elementary cognitive process or isolated to a neural circuit? A breakthrough neuroimaging study finds that fluid intelligence and attention control are behaviorally linked via the neural activity in brain areas involved in resolving cognitive conflict.     

Information search in the laboratory and on the Web: With or without an experimenter

The focus of this study is the effect of the location (laboratory vs. Web) of experiments on active information searchin decision-making tasks. In two experiments, participants were confronted with two different search method versions (list vs. keyword) for acquiring information about a task from a database. The amount and type of information gathered and the time required for task completion were measured. In Experiment 1, significantly more information was searched for in the laboratory than on the Web when the list version was employed, whereas there was no difference between locations in the keyword version. In Experiment 2, the participants were assigned randomly to the Web or the laboratory condition. The results of Experiment 1 were replicated. Whereas location (and the presence or absence of an experimenter) had an effect on the absolute amount of information gathered in both experiments, the relative distribution and type of information items did not differ.     

Introducing ethics and engineering: the case of Delft University of Technology

This article focuses mainly on (1) the policy of Delft University of Technology since 1992 as regards the university-wide introduction of a compulsory course on ethics and engineering, and (2) the ideal structure of such a course, including the educational goals of the course. Dr. G. J. Scheurwater is Senior policy-advisor to the Board of Delft University of Technology. Prof. S. J. Doorman is Chairman of the Advisory Committee on Ethics of Delft University of Technology.     

The ‘redefinition of death’ debate: Western concepts and western bioethics

Biomedicine is a global enterprise constructed upon the belief in the universality of scientific truths. However, despite huge scientific advances over recent decades it has not been able to formulate a specific and universal definition of death: In fact, in its attempt to redefine death, the concept of death appears to have become immersed in ever increasing vagueness and ambiguity. Even more worrisome is that bioethics, in the form of principlism, is also endeavouring to become a global enterprise by claiming neutrality. It appears that the discourse within both disciplines have similarly manipulated the boundaries of death to include the “dying”. This paper argues that the redefinition of death debate in biomedicine reveals a concept of personhood which is profoundly western in origin and which is in accordance to the concept adhered to within principlism. Biomedicine and bioethics do not appear to acknowledge the limitations of their own world view and hence lack an understanding of their applicability and appropriateness in diverse social and cultural contexts; a situation which adds credence to claims as to the hegemonic and imperialistic nature of all such global enterprises. Ms. Jones is an intensive care clinical nursing specialist. Dr. Kessel is a public health physician and medical ethicist.