LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein coupled receptors (GPCRs) that function to modulate neuronal excitation and plasticity via pre-synaptic, post-synaptic and glial mechanisms. Agonists for group II mGlu receptors (mGlu2 and mGlu3), such as LY354740, have been shown to suppress enhanced glutamatergic excitations in brain synapses known to be involved in the expression of fear/anxiety in animals and humans. Systemic administration of LY354740 increases open-arm time in the elevated plus maze in mice under conditions of moderate to severe stress, blocks the expression but not development of fear-potentiated startle in rats, prevents lactate-induced panic-like responses in panic-prone rats, and attenuates certain physiological, behavioral, and neurochemical consequences of acute stress in rodents. In these preclinical models, LY354740 does not produce the side-effects (e.g. sedation) that are associated with other anxiolytic agents such as benzodiazepines. Early clinical results with LY354740 have demonstrated safety and efficacy in a human anxiety model (panic provocation induced by CO2 challenge). Collectively, these data indicate mGlu2/3 receptor agonists such as LY354740 represent a promising new approach for treatment of anxiety and stress-related disorders in humans.     

What is manipulative behavior, anyway?

One of the most common ways of characterizing patients diagnosed with borderline personality disorder is that they are manipulative. Clinical usage of the term varies widely but clearly carries a pejorative meaning. Furthermore, behaviors that look similar to those called manipulative in clinical contexts are not called manipulative in broader society. It is crucial to become clear on what manipulation is, because studies show that carers routinely perceive BPD patients as manipulative and so have less empathy for them. In this paper the concept of manipulativity is clarified and its scope narrowed by distinguishing it from a number of related concepts, and a number of reasons why manipulating others is morally objectionable are suggested. I argue that, while some BPD patients may be manipulative, much of their behavior can and should be understood in a different light. Moral and clinical values are conflated in carers' judgments of manipulativity, and clinicians and researchers need to clarify when and why manipulative behavior is dysfunctional, and when it is merely morally wrong. Separating these two domains will enable carers to be more empathetic and less blaming of their patients' behavior.     

Temporal limits of selection and memory encoding: A comparison of whole versus partial report in rapid serial visual presentation

People often fail to recall the second of two visual targets presented within 500 ms in rapid serial visual presentation (RSVP). This effect is called the attentional blink. One explanation of the attentional blink is that processes involved in encoding the first target into memory are slow and capacity limited. Here, however, we show that the attentional blink should be ascribed to attentional selection, not consolidation of the first target. Rapid sequences of six letters were presented, and observers had to report either all the letters (whole-report condition) or a subset of the letters (partial-report condition). Selection in partial report was based on color (e.g., report the two red letters) or identity (i.e., report all letters from a particular letter onward). In both cases, recall of letters presented shortly after the first selected letter was impaired, whereas recall of the corresponding letters was relatively accurate with whole report.     

Constrained formation of object representations

Viewers were presented with a rapid sequence of very brief stimulus pairs, each of which consisted of a pictured object followed by a related or unrelated word. The form of relatedness between the picture and word was manipulated across experiments (identical concept, associated concept, ink color of the picture). Recognition memory for the pictures was affected not only by whether or not paired items were conceptually identical or semantically related, but also by whether or not the words named an irrelevant feature, ink color. These results show that sequential items are integrated on the basis of similarity at whatever level is available, so that the stability of the memory representation of one or both items is increased. We propose that a common mechanism may underlie integration, priming, and selective attention.     

The epidemiology of autistic spectrum disorders: is the prevalence rising?

For decades after Kanner's original paper on the subject was published in 1943, autism was generally considered to be a rare condition with a prevalence of around 2-4 per 10,000 children. Then, studies carried out in the late 1990s and the present century reported annual rises in incidence of autism in pre-school children, based on age of diagnosis, and increases in the age-specific prevalence rates in children. Prevalence rates of up to 60 per 10,000 for autism and even more for the whole autistic spectrum were reported. Reasons for these increases are discussed. They include changes in diagnostic criteria, development of the concept of the wide autistic spectrum, different methods used in studies, growing awareness and knowledge among parents and professional workers and the development of specialist services, as well as the possibility of a true increase in numbers. Various environmental causes for a genuine rise in incidence have been suggested, including the triple vaccine for measles, mumps and rubella (MMR]. Not one of the possible environmental causes, including MMR, has been confirmed by independent scientific investigation, whereas there is strong evidence that complex genetic factors play a major role in etiology. The evidence suggests that the majority, if not all, of the reported rise in incidence and prevalence is due to changes in diagnostic criteria and increasing awareness and recognition of autistic spectrum disorders. Whether there is also a genuine rise in incidence remains an open question.     

A Test of Competing Cognitive Explanations for the Boomerang Effect in Response to the Deliberate Disruption of Media-Induced Aggression

This study advances research on the boomerang effect in response to anti-aggression media literacy interventions. Previous findings indicate that elementary school children can become more aggressive after exposure to such interventions. We test two competing explanations for the boomerang effect, media priming and psychological reactance, in a 2 × 2 factorial experiment with elementary school children (N = 128). Findings indicate that children may cognitively process antisocial elements of an intervention program in a manner that runs counter to the intended effect of prosocial messages. Specifically, children who were exposed to a media literacy intervention with violent media clips as examples reported an increase in willingness to use aggression, whereas children who were exposed to the same lesson without the clips did not. Therefore, the boomerang effect is best explained by the processing of violent clips (media priming) and is not likely due to resistance to the instructional elements of the lesson (psychological reactance). Implications for researchers and practitioners are discussed.     

Beyond Cultivation: Exploring the Effects of Frequency,Recency, and Vivid Autobiographical Memories for Violent Media

Using Shrum's (1996) heuristic processing model as an explanatory mechanism, we propose that people who hold vivid autobiographical memories for a specific past experience with media violence will overstate the prevalence of real-world crime versus individuals without vivid memories. We also explore the effects of frequency and recency on social reality beliefs. A survey was administered to 207 undergraduate students who were asked to recall one violent television program or movie seen in the past. Participants were asked to write essays describing the violence, which were coded for vividness. Results support not only cultivation theory, but also the effects of memory vividness: participants with more vivid memories of blood and gore gave higher prevalence estimates of real-world crime and violence than participants with less vivid memories. Findings also suggest that females had more vivid memories for prior media violence than males. Implications for cultivation, the heuristic processing model, and vividness research are discussed.     

Religious disagreement: internal and external

Philosophers of religion have taken the assumption for granted that the various religious traditions of the world have incompatible beliefs. In this paper, I will argue that this assumption is more problematic than has been generally recognized. To make this argument, I will discuss the implications of internal religious disagreement, an aspect of this issue that has been too often ignored in the contemporary debate. I will also briefly examine some implications of my argument for how one might respond to the existence of religious diversity.     

COVID-19 Impact Battery: Development and Validation

In addition to impacting the physical health of millions of Americans, the novel-coronavirus (COVID-19) pandemic is a significant psychological stressor due to both the threat of the illness itself and the mitigation strategies used to contain the spread. To facilitate understanding of the impact of COVID-19, validated measures are needed. Using a stepwise procedure in line with best-practice measurement procedures, the current report summarizes the procedures employed to create the COVID-19 Impact Battery (CIB). Two independent samples recruited via Amazon Mechanical Turk (N?=?175, N?=?642) and a third community sample (N?=?259) were used for reliability and validity testing. Validation procedures yielded a battery consisting of three scales assessing COVID-19 related behaviors, worry, and disability. The behaviors scale contains three subscales assessing stockpiling, cleaning, and avoidance. The worry subscale also contains three subscales assessing health, financial and catastrophic concerns. In addition, we created a short version of the battery (CIB-S) to allow for more flexibility in data collection. In summary, we have provided reliability and validity information for the CIB and CIB-S, demonstrating that these measures can facilitate evaluation of the broad impact of COVID-19 on mental health functioning.