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Two experiments were performed on Sprague-Dawley rats to study the effects of noradrenaline and 5-hydroxytryptamine depletion upon the antinociceptive effects of acute 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) administration. 6-Hydroxydopamine-induced lesions following microinjections to either the locus coeruleus or the spinal cord (lumbar) abolished completely 5-MeODMT-induced analgesia in the tail-flick, hot-plate, and shock titration tests whereas 5,7-dihydroxytryptamine-induced lesions of the nucleus raphe magnus and the lumbar spinal cord attenuated 5-MeODMT analgesia in the tail-flick and shock titration tests. Thus, the experiments serve to demonstrate an important interaction between descending noradrenergic and serotonergic pathways, possibly at a spinal locus. 相似文献
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Visually perceived eye level (VPEL) and the ability of subjects to reach with an unseen limb to targets placed at VPEL were measured in a statically pitched visual surround (pitchroom). VPEL was shifted upward and downward by upward and downward room pitch, respectively. Accuracy in reaching to VPEL represented a compromise between VPEL and actual eye level. This indicates that VPEL shifts reflect in part a change in perceived location of objects. When subjects were provided with terminal visual feedback about their reaching, accuracy improved rapidly. Subsequent reaching, with the room vertical, revealed a negative aftereffect (i.e., reaching errors that were opposite those made initially in the pitched room). In a second study, pointing accuracy was assessed for targets located both at VPEL and at other positions. Errors were similar for targets whether located at VPEL or elsewhere. Additionally, pointing responses were restricted to a narrower range than that of the actual target locations. The small size of reaching and pointing errors in both studies suggests that factors other than a change in perceived location are also involved in VPEL shifts. 相似文献
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Traditional approaches to inhibited sexual hire (ISD)—which may be exclusively heterosexist, erotophobic, sexist, and homophobic—fail to adequately address ISD within the lesbian population, in which incest and substance abuse occur commonly. Successful treatment of ISD among lesbians requires awareness of sexual minority customs, lesbian psychologies, and recovery agendas. 相似文献
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Effects of stimulus probability and prediction outcome on two-choice reaction speed (CRS) were determined when a frequency imbalance was reversed half-way through 300 samples of a 70/30 stimulus distribution and when the same 70/30 distribution was sampled for 1200 trials. Prior to each presentation Ss made a prediction; following each presentation Ss identified the stimulus by pressing a right-hand or left-hand trigger. CRS was faster to correctly predicted stimuli, and faster to the more probable stimulus. Ss who were informed of the frequency imbalance reacted significantly faster than Ss who were not. Both practice and boredom effects were demonstrated by using the extended number of trials. CRS was faster during the second session of 300 trials than during the first; after two sessions, CRS was slower during the second half of two additional sessions. 相似文献
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The sum of induced and real motion is not a straight path 总被引:1,自引:0,他引:1