Altered Cortico-Limbic Functional Connectivity During an Empathy Task in Subjects with Post-Traumatic Stress Disorder

Empathy is a multidimensional construct consisting of cognitive (inferring mental states) and emotional (empathic concern) components. Emotional empathy is severely impaired in individuals affected by Post-Traumatic Stress Disorder (PTSD). Here, we investigated the neural correlates of such an emotional empathy dysfunction to shed light on the neural circuitry responsible for the social and emotional dysfunction in PTSD. We asked a group of PTSD and a group of healthy controls to solve a Multifaceted Empathy Test, measuring both cognitive and emotional empathy, and investigated the functional connectivity of the cortical areas involved in solving the test. The results revealed that, in healthy individuals, increased neural activity in the frontal cortex modulates activity in the insula while subjects perform the emotional empathy task; whereas, in individuals affected by PTSD, increased activity in limbic regions such the insula and the amygdala modulates activity in the frontal cortex while performing the emotional empathy task. These findings suggest that the lack of cortical top-down control of the frontal cortex on the limbic system in PTSD during empathic processing may explain the emotional and social difficulties experienced by individuals suffering from PTSD.     

On the Relationships between Sum Score Based Estimation and Joint Maximum Likelihood Estimation

This paper analyzes the sum score based (SSB) formulation of the Rasch model, where items and sum scores of persons are considered as factors in a logit model. After reviewing the evolution leading to the equality between their maximum likelihood estimates, the SSB model is then discussed from the point of view of pseudo-likelihood and of misspecified models. This is then employed to provide new insights into the origin of the known inconsistency of the difficulty parameter estimates in the Rasch model. The main results consist of exact relationships between the estimated standard errors for both models; and, for the ability parameters, an upper bound for the estimated standard errors of the Rasch model in terms of those for the SSB model, which are more easily available. The authors acknowledge partial financial support from the FONDECYT Project No. 1060722 from the Chilean Government, and the BIL05/03 grant to P. De Boeck, E. Lesaffre and G. Molenberghs (Flanders) for a collaboration with G. del Pino, E. San Martín, F. Quintana and J. Manzi (Chile).     

Clamped Corticosterone (B) Reveals the Effect of Endogenous B on Both Facilitated Responsivity to Acute Restraint and Metabolic Responses to Chronic Stress

To determine the effects of both corticosterone (B) and chronic stressors on acute ACTH responses to restraint, young male rats were exposed to streptozotocin-induced diabetes, cold (5-7 degreesC) or intracerebroventricular (icv) neuropeptide Y (NPY) for 5 d and then exposed to restraint within 2 h after lights on. Two groups of rats were studied: intact and adrenalectomized replaced with B pellets that maintained plasma B in the normal mean 24-h range of intact rats. In addition to ACTH and B responses to restraint on d 5, body weight, food intake, fat depots, glucose and other hormones were measured to determine the role of stress-induced elevations in B on energy balance. ACTH responses to restraint were normal in intact rats subjected to diabetes or cold. By contrast, there was no ACTH or B response to restraint in NPY-infused intact rats. All 3 groups of chronically stimulated adrenalectomized rats with clamped B had facilitated ACTH responses to restraint compared to their treatment controls. Overall food intake increased in all groups of stressed rats; however, augmented intake occurred only during the light in intact rats and equally in the light and dark in B-clamped rats. White adipose depot weights were decreased by both diabetes and cold and increased by NPY in intact rats; the decreases with cold and increases with NPY were both blunted and changes in fat stores were not significant in adrenalectomized, B-clamped rats. We conclude that: 1. diabetes- and cold-induced facilitation of restraint-induced afferent input to hypothalamic control of the hypothalamo-pituitary-adrenal (HPA) axis is opposed in intact rats by the elevated feedback signal of B secretion; 2. NPY does not induce facilitation of afferent stress pathways; 3. chronic stimulation of the HPA axis induces acute hyperresponsiveness of hypothalamic neurons to restraint provided that the afferent input of this acute stimulus is not prevented by B feedback; 4. stimulus-induced elevations in B secretion result in day-time feeding; 5. insensitivity of both caloric efficiency and white fat stores to chronic stress in adrenalectomized, B-clamped rats results from loss of normally variable B levels.     

Less exploring by mouth occurs in newborns of depressed mothers

Twenty‐four newborns (M age = 12 days) of depressed and nondepressed mothers were assessed for oral perception of a nubby and smooth texture. Both groups of newborns discriminated between these textures and showed a sucking preference for the smooth texture. However, the newborns of depressed mothers spent 50% less time orally exploring the stimuli, one‐third less time exploring the more novel nubby texture, and 59% less time mouthing the smooth texture. Newborns of depressed mothers may have biological differences that affect their emotional arousal and emotional regulation (e.g., capacity for self‐soothing). © 2000 Michigan Association for Infant Mental Health.     

Interactions between apparent motion rivalry in vision and touch

In multistable perception, the brain alternates between several perceptual explanations of ambiguous sensory signals. It is unknown whether multistable processes can interact across the senses. In the study reported here, we presented subjects with unisensory (visual or tactile), spatially congruent visuotactile, and spatially incongruent visuotactile apparent motion quartets. Congruent stimulation induced pronounced visuotactile interactions, as indicated by increased dominance times for both vision and touch, and an increased percentage bias for the percept already dominant under unisensory stimulation. Thus, the joint evidence from vision and touch stabilizes the more likely perceptual interpretation and thereby decelerates the rivalry dynamics. Yet the temporal dynamics depended also on subjects' attentional focus and was generally slower for tactile than for visual reports. Our results support Bayesian approaches to perceptual inference, in which the probability of a perceptual interpretation is determined by combining visual, tactile, or visuotactile evidence with modality-specific priors that depend on subjects' attentional focus. Critically, the specificity of visuotactile interactions for spatially congruent stimulation indicates multisensory rather than cognitive-bias mechanisms.     

Parenting styles and their relationship with hyperactivity

The present study aims to determine the relationship among factors that make up the parenting styles according to the PCRI (Parent-Child Relationship Inventory) and hyperactivity reported by parents through the BASC (Behaviour Assessment System for Children). We selected a sample of 32 children between 3 and 14 years old (23 male and 9 female) with risk scores in hyperactivity and another similar group with low scores in hyperactivity. After administering both instruments to the parents, we carried out a binomial logistic regression analysis which resulted in a prediction model for 84.4% of the sample, made up of the PCRI factors: fathers' involvement, communication and role orientation, mothers' parental support, and both parents' limit-setting and autonomy. Moreover, our analysis of the variance produced significant differences in the support perceived by the fathers and mothers of both groups. Lastly, the utility of results to propose intervention strategies within the family based on an authoritative style is discussed.     

Intercultural Study of Personal Space: A Case Study

The study of intercultural differences in personal space attempts to identify factors that could be helpful in guiding people from different cultures to live and work together in international ventures. The objective of this research was to measure interpersonal distance in a cross-cultural environment. Twenty-three participants classified in 4 cultural groups answered an 11-questions interview where the personal distance and orientation between seated interactants were measured. Results showed that Anglo Saxons used the largest zone of personal space, followed by Asians, then Caucasians, and, as expected, Mediterraneans and Latinos used the shortest distance. Where Latinos adopt a face-to-face position, Caucasians tend to orient themselves to the side of the interviewer, which has an impact on interpersonal communication.     

Daily life activity patterns among the elderly: is what they claim to do what they wish to do?

This study is aimed at exploring daily and desired activity patterns in a sample of older people, as well as at examining some influence factors and their relationships to life satisfaction. Our sample was made of 154 retired people living in urban areas and whose age was greater than 60 years old. Data about activities were gathered by means of an interview while life satisfaction scores were obtained by applying LSI scale. Our results show how the pattern of activities that our participants say to have done yesterday is quite similar to an ideal pattern, although in the ideal day time spent with other people is far greater. Factors like gender and economic and educational level have an influence on patters of activity, especially on instrumental and leisure ones. The difference between yesterday and ideal activities was negatively related to life satisfaction. Such a relationship was modest, but reached statistical significance.     

Reluctant to change: Self-enhancing responses to diverging performance measures

Although there is extensive evidence that past performance influences the propensity to make changes, research on how decision makers respond to diverging performance measures has been sparse. This paper addresses this gap in an experimental and a field study in which we examine how decision makers respond to the ambiguity introduced by two diverging performance indicators of unequal importance. Both studies suggest that decision makers respond to diverging performance indicators in a self-enhancing manner. Decision makers gave importance to a secondary performance indicator only when it helped them maintain a sense of positive performance, that is, when a secondary performance measure was high and a primary performance measure was low. The results suggest that, in contexts in which decision makers are likely to experience diverging performance indicators, perceptions of success and the associated reluctance to make changes might be more pervasive than is often thought.