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51.
Henri-Corto Stoeklé Marie-France Mamzer-Bruneel Charles-Henry Frouart Christophe Le Tourneau Pierre Laurent-Puig Guillaume Vogt Christian Hervé 《Science and engineering ethics》2018,24(1):307-322
The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine” (DM) (big data, data mining). The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision of care. Molecular tumor boards (MTB) are one response to these changes and are now providing better access to next-generation sequencing (NGS) and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent (IC) documents at all academic medical centers and to introduce dynamic and electronic informed consent (e-IC). 相似文献
52.
ABSTRACTThree-to-five-year-old French children were asked to add or remove objects to or from linear displays. The hypothesis of a universal tendency to represent increasing number magnitudes from left to right led to predict a majority of manipulations at the right end of the rows, whatever children's hand laterality. Conversely, if numbers are not inherently associated with space, children were expected to favour laterality-consistent manipulations. The results showed a strong tendency to operate on the right end of the rows in right-handers, but no preference in left-handers. These findings suggest that the task elicited a left-to-right oriented representation of magnitudes that counteracted laterality-related responses in left-handed children. The young age of children and the lack of a developmental trend towards right preference weaken the hypothesis of a cultural origin of this oriented representation. The possibility that our results are due to weaker brain lateralisation in left-handers compared to right-handers is addressed in Discussion section. 相似文献
53.
Anne-Françoise de Chambrier Catherine Thevenot Pierre Barrouillet Pascal Zesiger 《Journal of Cognitive Psychology》2018,30(5-6):503-510
Finger counting can be useful in solving arithmetic problems, noticeably because it reduces the working memory demand of mental calculations. However, proprioceptive information might not be sufficient to keep track of the number of fingers raised during problem solving, and visual input may play an important role in this process. The present study was designed to address this question and shows that 8-year-old children look at their fingers in 60% of the trials during finger counting when solving additive problems. Moreover, our results reveal that the frequency of finger looking is negatively correlated with working memory capacities and is higher for more difficult problems. These findings suggest that finger looking is recruited in managing the cognitive demand of the arithmetic task, probably by providing additional external cues to monitor the number of steps that have to be incremented during finger counting. 相似文献
54.
Recent theoretical accounts of verbal and visuo-spatial short-term memory (STM) have proposed the existence of domain-general mechanisms for the maintenance of serial order information. These accounts are based on the observation of similar behavioural effects across several modalities, such as temporal grouping effects. Across two experiments, the present study aimed at extending these findings, by exploring a STM modality that has received little interest so far, STM for musical information. Given its inherent rhythmic, temporal and serial organisation, the musical domain is of interest for investigating serial order STM processes such as temporal grouping. In Experiment 1, the data did not allow to determine the presence or the absence of temporal grouping effects. In Experiment 2, we observed that temporal grouping of tone sequences during encoding improves short-term recognition for serially presented probe tones. Furthermore, the serial position curves included micro-primacy and micro-recency effects, which are the hallmark characteristic of temporal grouping. Our results suggest that the encoding of serial order information in musical STM may be supported by temporal positional coding mechanisms similar to those reported in the verbal domain. 相似文献
55.
56.
In an associative recognition task, distractors generally consist of a rearrangement of the items composing the study pairs.
This makes it possible that processing the distractors generates retroactive interference on memory for the study pairs. In
Experiment 1, we explored this possibility in ayes/no recognition test concerning previously learned arbitrary associations between visual symbols and auditory syllables. Rearranged
pairs had a deleterious impact on the accuracy and the speed of responses to related correct pairs. This effect did not vary
as a function of the number of training blocks, and furthermore, in Experiment 2, the same effect was observed for overlearned
small multiplication facts. These results suggest that exposure to potentially confounding information generates interference
even if this information is known to be incorrect. Some implications are outlined, especially with regard to the widespread
use of multiple-choice tests in knowledge evaluation. 相似文献
57.
The present study examined the impact of different modes of processing anxious apprehension on subsequent anxiety and performance in a stressful speech task. Participants were informed that they would have to give a speech on a difficult topic while being videotaped and evaluated on their performance. They were then randomly assigned to one of three conditions. In a specific processing condition, they were encouraged to explore in detail all the specific aspects (thoughts, emotions, sensations) they experienced while anticipating giving the speech; in a general processing condition, they had to focus on the generic aspects that they would typically experience during anxious anticipation; and in a control, no-processing condition, participants were distracted. Results revealed that at the end of the speech, participants in the specific processing condition reported less anxiety than those in the two other conditions. They were also evaluated by judges to have performed better than those in the control condition, who in turn did better than those in the general processing condition. 相似文献
58.
Juliette Gatto Michaël Dambrun Christian Kerbrat Pierre De Oliveira 《European journal of social psychology》2010,40(2):252-269
The principal aim of this study is to determine why police officers are generally found to be more prejudiced towards disadvantaged groups than are the standard population. Two independent processes were expected to account for this effect: Selection and group socialisation. Using a cross‐sectional design (N = 170), firstly, we compared, newly recruited police officers with a control population (selection effect), and secondly, police officers with 1 year of training with the newly recruited ones (group socialisation effect). Results reveal a significant effect of both selection and group socialisation, the two being underlined by distinct processes; right‐wing authoritarianism (RWA) in the case of the former and internalisation of a prejudice norm in the case of the latter. Finally, the results show that group identification moderates the change in internalisation of the prejudice norm. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
59.
The purpose of this study was to compare the effectiveness of two different forms of reciprocal peer tutoring (RPT) on the motor and cognitive performance of adolescents in a physical education setting. We also explored the influence of gender. We assigned 72 ninth-graders (36 M, 36 F), all novices in a table tennis task, to a 2 × 3 (Gender × Learning Condition: physical practice with trained RPT [TRPT] vs. physical practice with spontaneous RPT [SRPT]vs. physical practice without any form of RPT [PP; individual control condition]) factorial design. Results indicated superior motor performance and cognitive skills for the TRPT condition and no difference between the SRPT and PP conditions. The peer-tutor training was thus a crucial organizational variable of the success of RPT. Interestingly, our results support the assumption that females particularly benefit from a highly structured peer tutoring framework. 相似文献
60.
The effects of Asian and Caucasian facial morphology were examined by having Canadian children categorize pictures of facial expressions of basic emotions. The pictures were selected from the Japanese and Caucasian Facial Expressions of Emotion set developed by D. Matsumoto and P. Ekman (1989). Sixty children between the ages of 5 and 10 years were presented with short stories and an array of facial expressions, and were asked to point to the expression that best depicted the specific emotion experienced by the characters. The results indicated that expressions of fear and surprise were better categorized from Asian faces, whereas expressions of disgust were better categorized from Caucasian faces. These differences originated in some specific confusions between expressions. 相似文献