Loci of signal probability effects and of the attentional blink bottleneck

To investigate the locus of signal probability effects and the influence of stimulus quality on this locus, the authors manipulated probability in Task 2 of a psychological refractory period (PRP) paradigm. The effect was additive with stimulus onset asynchrony (SOA) when the target was not masked but underadditive with decreasing SOA when the target was masked. Even with masking, however, a range of probabilities had effects additive with SOA. The results suggest loci of stimulus probability before the PRP bottleneck as well as at or after the bottleneck. A second issue addressed was the locus of interference in the attentional blink (AB). The AB was larger when the probability of the first of 2 targets was lower. The results lead to the conclusion that one cause of the AB effect is a locus at least as late as the PRP bottleneck.     

Performance and reaction times in monaural localization of first names in the horizontal plane

Many studies have been conducted to measure monaural azimuthal sound localization performance with different sounds varying in frequency and complexity, but few have used linguistic stimuli. The present experimental design used subjects' first names in a monaural azimuthal localization task. Analysis of response accuracy showed that subjects are not more accurate in localizing their own first name than in localizing other first names and that there was no significant advantage of one ear over another. Reaction times were shorter when the subjects localized their own first name than when they localized any other first names and there was no significant ear advantage, but localizing other first names took more time with the right than with the left ear. All stimuli were better and more quickly localized on the side of the open ear, and there was no difference in acuity or velocity of localization with the two different speaker voices used. These results suggest that first names are processed through the controlateral auditory pathway and can be analyzed in the right hemisphere.     

Applicability of the ADA to "Ticket to Work" employment networks. Americans with Disabilities Act

This article examines the applicability of the antidiscrimination provisions of the Americans with Disabilities Act (ADA) of 1990 to The Ticket to Work and Work Incentives Improvement Act (TWWIIA) passed in 1999. Among other policy changes, under the Ticket to Work program, eligible recipients of disability insurance (SSDI) and supplemental income (SSI) receive a voucher or "ticket" to obtain services from qualified employment networks (ENs). ENs provide employment services and supports to designated beneficiaries and must meet certain qualification requirements. The ADA is applicable to ENs in several ways: primarily, in the EN's responsibility to provide appropriate access and services to program participants. This article discusses application of the ADA to the Ticket Program as ENs begin to serve program beneficiaries.     

Aging and autobiographical memory: dissociating episodic from semantic retrieval

Cognitive aging research documents reduced access to contextually specific episodic details inolder adults, whereas access to semantic or other nonepisodic information is preserved or facilitated. The present study extended this finding to autobiographical memory by using a new measure; the Autobiographical Interview. Younger and older adults recalled events from 5 life periods. Protocols were scored according to a reliable system for categorizing episodic and nonepisodic information. Whereas younger adults were biased toward episodic details reflecting happenings, locations, perceptions, and thoughts, older adults favored semantic details not connected to a particular time and place. This pattern persisted after additional structured probing for contextual details. The Autobiographical Interview is a useful instrument for quantifying episodic and semantic contributions to personal remote memory.     

Dissociation between priming and recognition in the expression of sequential knowledge

Exposure to a repeating sequence of target stimuli in a speeded localization task can support both priming of sequence-consistent responses and recognition of sequence components. Here, a task is introduced in which measures of priming and recognition are obtained concurrently, and it is demonstrated that priming of sequence-consistent responses occurs even when test stimuli are not recognized. The results show that sequence knowledge can be expressed in the absence of conscious recognition. However, we also show that this result is consistent with a simple model in which priming and recognition depend on exactly the same underlying memory strength variable.     

Sentence context,word recognition,and repetition blindness

When the sentence She ran her best time yet in the rice last week is displayed using rapid serial visual presentation, viewers sometimes misread rice as race (M. C. Potter, A. Moryadas, I. Abrams, & A. Noel, 1993). Seven experiments combined misreading and repetition blindness (RB) paradigms to determine whether misreading of a word because of biasing sentence context represents a genuine perceptual effect. In Experiments 1-4, misreading a word either caused or prevented RB for a downstream word, depending on whether orthographic similarity was increased or decreased. Additional experiments examined temporal parameters of misreading RB and tested the hypothesis that RB results from reconstructive memory processes. Results suggest that the effect of prior context occurs during perception.     

Toward optimal treatments for major depression

The treatment of major depression remains problematic for several reasons. In particular, the therapeutic response to medications usually does not manifest itself until a week after administration has begun, and more than half the patients will not experience a full recovery with the first antidepressant drug administration. There are, however, some pharmacologic strategies that can accelerate antidepressant response. When facing a treatment-resistant depression, combination therapy offers a more time-efficient approach to achieve remission than drug substitution. These interventions have been devised on a better understanding of the basis for the therapeutic response obtained with the first- and second-generation antidepressants, and evidence derived from controlled clinical trials of their superior effectiveness is growing. The rationale for such approaches will be described in this article, as well as their advantages and potential inconveniences. Ongoing research in this field continues to fuel the development of novel, better-tolerated, and more effective pharmacotherapies for depression.     

All-or-none bottleneck versus capacity sharing accounts of the psychological refractory period phenomenon

The goal of the present experiment was to test the predictions of Central Bottleneck and Central Capacity Sharing models. According to the Central Bottleneck model, dual task interference, as observed in the PRP paradigm, is caused by an all-or-none bottleneck in information processing. The Central Capacity Sharing model postulates that dual task interference is caused by a capacity limited process that can allocate capacity in a graded fashion. The Central Bottleneck model predicts no change in RT1 with decreasing SOA, whereas the Central Capacity Sharing model predicts that RT1 will increase with decreasing SOA and that the slope of the RT1 SOA effect will depend upon the difficulty of task 2. Subjects were required to perform a tone pitch judgement and shape-matching task in rapid succession. Task order was randomized and the SOA between the first and second stimulus varied from 50 to 1250 ms. Results from this experiment favour the Central Capacity Sharing model. The results were then run through simulations of both the Central Bottleneck and Central Capacity Sharing models. Results from the simulations also favoured the Central Capacity Sharing model. As the difficulty of the second task increased, more capacity was allocated to it, confirming the prediction that as task 2 difficulty increases, the RT1 SOA slope increases. The proportion of capacity allocated to the first task varied from.78 to.91 indicating that capacity can be allocated in a graded fashion.     

Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze

Serotonin (5-HT) plays a modulatory role in mnemonic functions, especially by interacting with the cholinergic system. The 5-HT1B receptor is a key target of this interaction. The 5-HT1B receptor knockout mice were found previously to exhibit a facilitation in hippocampal-dependent spatial reference memory learning. In the present study, we submitted mice to a delayed spatial working memory task, allowing the introduction of various delays between an exposure trial and a test trial. The 5-HT1BKO and wild-type mice learned the task in a radial-arm water maze (returning to the most recent presented arm containing the escape platform), and exhibited a high level of performance at delays of 0 and 5 min. However, at the delay of 60 min, only 5-HT1BKO mice exhibited an impairment. At a delay of 90 min, all mice were impaired. Treatment by scopolamine (0.8 mg/kg) induced the same pattern of performance in wild type as did the mutation for short (5 min, no impairment) and long (60 min, impairment) delays. The 22-month-old wild-type and knockout mice exhibited an impairment at short delays (5 and 15 min). The effect of the mutation affected both young-adult and aged mice at delays of 15, 30, and 60 min. Neurobiological data show that stimulation of the 5-HT1B receptor inhibits the release of acetylcholine in the hippocampus, but stimulates this in the frontal cortex. This dual function might, at least in part, explain the opposite effect of the mutation on reference memory (facilitation) and delay-dependent working memory (impairment). These results support the idea that cholinergic-serotonergic interactions play an important role in memory processes.