Spinal and locus coeruleus noradrenergic lesions abolish the analgesic effects of 5-methoxy-N,N-dimethyltryptamine

Two experiments were performed on Sprague-Dawley rats to study the effects of noradrenaline and 5-hydroxytryptamine depletion upon the antinociceptive effects of acute 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) administration. 6-Hydroxydopamine-induced lesions following microinjections to either the locus coeruleus or the spinal cord (lumbar) abolished completely 5-MeODMT-induced analgesia in the tail-flick, hot-plate, and shock titration tests whereas 5,7-dihydroxytryptamine-induced lesions of the nucleus raphe magnus and the lumbar spinal cord attenuated 5-MeODMT analgesia in the tail-flick and shock titration tests. Thus, the experiments serve to demonstrate an important interaction between descending noradrenergic and serotonergic pathways, possibly at a spinal locus.     

Accuracy and adaptation of reaching and pointing in pitched visual environments

Visually perceived eye level (VPEL) and the ability of subjects to reach with an unseen limb to targets placed at VPEL were measured in a statically pitched visual surround (pitchroom). VPEL was shifted upward and downward by upward and downward room pitch, respectively. Accuracy in reaching to VPEL represented a compromise between VPEL and actual eye level. This indicates that VPEL shifts reflect in part a change in perceived location of objects. When subjects were provided with terminal visual feedback about their reaching, accuracy improved rapidly. Subsequent reaching, with the room vertical, revealed a negative aftereffect (i.e., reaching errors that were opposite those made initially in the pitched room). In a second study, pointing accuracy was assessed for targets located both at VPEL and at other positions. Errors were similar for targets whether located at VPEL or elsewhere. Additionally, pointing responses were restricted to a narrower range than that of the actual target locations. The small size of reaching and pointing errors in both studies suggests that factors other than a change in perceived location are also involved in VPEL shifts.     

Gender and family factors as predictors of late adolescent emotional expressiveness and adjustment: A longitudinal study

This study examined the longterm effects of the socialization of emotion in a sample of European American families. Late adolescents, whose families had been more emotionally expressive and accepting of emotions when they were in fifth grade, were more likely to report showing emotions not traditionally associated with their gender roles—specifically, males reported a greater propensity for crying, and females reported a greater tendency to express anger. In addition, in late adolescence, greater frequency of showing fear and showing warmth or affection were associated with higher levels of social and psychological adjustment—whereas crying was associated with better adjustment for males and poorer adjustment for females. Overall, adolescent females tended to report a higher level of emotional expressiveness and a higher level of family support of emotions than did adolescent males.     

Therapeutic approaches to inhibited sexual desire in lesbians

Traditional approaches to inhibited sexual hire (ISD)—which may be exclusively heterosexist, erotophobic, sexist, and homophobic—fail to adequately address ISD within the lesbian population, in which incest and substance abuse occur commonly. Successful treatment of ISD among lesbians requires awareness of sexual minority customs, lesbian psychologies, and recovery agendas.     

Psychosocial Adjustment of Adult Cancer Survivors: Their Needs and Counselor Interventions

The author presents an overview of the literature on the psychosocial adjustment of cancer survivors, identifying 4 areas that may pose difficulties for cancer survivors as they learn to live with a life-threatening chronic illness: coping with the late physical effects of treatment; living with the uncertainty of long-term survival; resolving problems related to intimacy, marriage, and reproduction; and combating employment discrimination. Counseling interventions are proposed for counselors working with cancer survivors on these issues.     

How Generalizable Are Adolescents' Beliefs About Pro-Drug Pressures and Resistance Self-Efficacy?1

Based on three waves of data from 1261 adolescents, this study examines the nature of resistance self-efficacy vis-a-vis different drugs and social situations, as well as its relationship to perceived pressure to use drugs. We found that both self-efficacy and perceived pressure to use drugs appear to be generalizable across substances (alcohol, cigarettes, and marijuana), but adolescents do tend to distinguish between their capacity to resist drugs in different social situations. Adolescents also discriminate between how much pressure they feel and their ability to resist that pressure, but the great majority report lower levels of self-efficacy in higher pressure situations. This relationship is strongest for alcohol and weakest for marijuana. These results suggest the following implications for prevention programs: (a) adolescents can be taught to resist one or more of the commonly used drugs with a reasonable expectation that the skills will generalize to other drugs; (b) resistance self-efficacy learned in one situation can be expected to have some generalizability to other situations, but it may be important to link resistance training with a range of situations to insure the greatest effectiveness; (c) to be maximally effective, prevention programs may need to help adolescents reduce the amount of pressure experienced as well as develop resistance skills; such efforts are likely to be particularly important for situations involving alcohol.