Individual differences in cognitive plasticity: an investigation of training curves in younger and older adults

To date, cognitive intervention research has provided mixed but nevertheless promising evidence with respect to the effects of cognitive training on untrained tasks (transfer). However, the mechanisms behind learning, training effects and their predictors are not fully understood. Moreover, individual differences, which may constitute an important factor impacting training outcome, are usually neglected. We suggest investigating individual training performance across training sessions in order to gain finer-grained knowledge of training gains, on the one hand, and assessing the potential impact of predictors such as age and fluid intelligence on learning rate, on the other hand. To this aim, we propose to model individual learning curves to examine the intra-individual change in training as well as inter-individual differences in intra-individual change. We recommend introducing a latent growth curve model (LGCM) analysis, a method frequently applied to learning data but rarely used in cognitive training research. Such advanced analyses of the training phase allow identifying factors to be respected when designing effective tailor-made training interventions. To illustrate the proposed approach, a LGCM analysis using data of a 10-day working memory training study in younger and older adults is reported.     

Long-term response-stimulus associations can influence distractor-response bindings

Strong associations between target stimuli and responses usually facilitate fast and effortless reactions. The present study investigated whether long-term associations between distractor stimuli and responses modulate behavior. In particular, distractor stimuli can affect behavior due to distractor-based stimulus-response retrieval, a phenomenon called distractor-response binding: An ignored stimulus becomes temporarily associated with a response and retrieves it at stimulus repetition. In a flanker task, participants ignored left and right pointing arrows and responded to a target letter either with left and right (strongly associated) responses or with upper and lower (weakly associated) responses. Binding effects were modulated in dependence of the long-term association strength between distractors and responses. If the association was strong (arrows pointing left and right with left and right responses), binding effects emerged but only in case of compatible responses. If the long-term association between distractors and responses was weak (arrows pointing left and right with upper and lower responses), binding was weaker and not modulated by compatibility. In contrast, sequential compatibility effects were not modulated by association strength between distractor and response. The results indicate that existing long-term associations between stimuli responses may modulate the impact of an ignored stimulus on action control.     

血管壁切应力的优与非优

在生理水平的血管壁切应力属于优性因子,能促进血管重建,抑制内皮细胞凋亡,调节内皮细胞分泌功能,使内皮细胞形态产生适应性变化;而显著升高或降低的血管壁切应力则属于非优因子,导致高血压恶性循环发生、促进动脉粥样硬化及动脉血栓形成。实现切应力非优向优转化的重要途径是降低高血压和选择性阻断切应力对基因表达的调节     

国际合作中知情同意面临的难题及思考

目前在医学研究的国际合作中,知情同意原则在实施中出现了许多争议和难题.结合一些典型案例,对知情同意的跨文化研究、知情同意表格的误解以及保护受试者与自由研究之间的权衡等问题进行了深入地分析.指出:加强交流、相互尊重、求同存异是解决跨文化研究的必由之路;严格审查、加强监管是避免知情同意流于形式的重要手段;鼓励与防范并举才能达到双赢的局面.     

Does Reducing Male Domination in Teams Attenuate or Intensify the Harmful Effects of Perceived Discrimination on Women's Job Satisfaction? A Test of Competing Hypotheses

This study tested competing theoretical predictions surrounding the moderating effect of male domination in teams on the relation between women's perceptions of gender discrimination and their job satisfaction. Using archival data from an all-female sample of active military personnel (n = 3,015) comprising 321 work teams, which fell on a continuum from less male dominated to more male dominated, we found that the extent to which teams were male dominated moderated the negative link between perceived gender discrimination and job satisfaction, such that perceptions of discrimination were more negatively related to job satisfaction for women working in teams that were less male dominated than for those working in teams that were more male-dominated. We conclude by discussing the implications of our findings for research and practice and highlight several avenues for future research.     

“Who said it?” How contextual information influences perceived profundity of meaningful quotes and pseudo-profound bullshit

Psychological research on pseudo-profound bullshit—randomly assembled buzz words plugged into a syntactic structure—has only recently begun. Most such research has focused on dispositional traits, such as thinking styles or political orientation. However, none has investigated contextual factors. In two studies, we introduce a new paradigm by investigating the contextual effect on pseudo-profound bullshit and meaningful quotes. In Study 1, all participants rated the profundity of statements in three contexts: (a) isolated, (b) as allegedly said by a famous author, or (c) within a vignette (short story). Study 2 serves as a conceptual replication in which participants rated statements in only one of three contexts. Overall, our results demonstrate that although contextual information such as author's name increases the perceived profundity of bullshit, it has an inconsistent effect on meaningful quotes. The present study helps to better understand the bullshit receptivity while offering a new line of research.     

Molecular Tumor Boards: Ethical Issues in the New Era of Data Medicine

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine” (DM) (big data, data mining). The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision of care. Molecular tumor boards (MTB) are one response to these changes and are now providing better access to next-generation sequencing (NGS) and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent (IC) documents at all academic medical centers and to introduce dynamic and electronic informed consent (e-IC).     

Is two better than one? Comparing children’s narrative competence in an individual versus joint storytelling task

This research looks at the potential of peer interaction practices in improving narrative competence by analyzing the efficacy of peer learning on children’s oral narrative productions. Gains on a macro-level (structure and coherence of the narrative) and a micro-level (cohesion of the narrative) were analyzed. Fifty-six primary school children participated in this study. Each child told a narrative either individually (individual condition) or while interacting with a peer (joint condition). We explored whether children produced longer, more structured, coherent and cohesive narratives in a joint condition rather than individually, and in which condition the joint task was more beneficial for children’s narrative competence in terms of narrative scores in the individual condition, discrepancy between the members of the same pair, and quality of the interaction. The advantage of peer learning does not derive from the direct comparison of the individual versus the joint condition but depends on specific conditions: the joint condition was beneficial for individuals with lower individual competence and for pairs with a high discrepancy between individual scores. Children’s quality of interaction did not seem to influence the efficacy of peer learning on their narrative competence.     

The Guise of the Bad in Augustine’s Pear Theft

In the second book of his Confessions, Augustine of Hippo presents his famous juvenile Pear Theft as an apparent case of acting under the guise of the bad. At least since Thomas Aquinas’ influential interpretation, scholars have usually taken Augustine’s detailed discussion of the case to be dispelling this “guise of the guise of the bad”, and to offer a solid “guise of the good”-explanation. This paper addresses an important challenge to this view: Augustine offers two different “guise of the good”-explanations in his text rather than just one, and the two explanations seem to be mutually exclusive. A number of more recent attempts to reconcile Augustine’s two lines of explanation are discussed and found wanting, and a new suggestion is made. The proposed solution focuses on the Pear Theft as a joint action, and it departs from the Aquinian interpretation in that it accounts for a way in which the “guise of the bad”-hypothesis survives the explanation.