A note on verisimilitude and relativization to problems

This note aims at critically assessing a little-noticed proposal made by Popper in the second edition ofObjective Knowledge to the effect that verisimilitude of scientific theories should be made relative to the problems they deal with. Using a simple propositional calculus formalism, it is shown that the relativized definition fails for the very same reason why Popper's original concept of verisimilitude collapsed-only if one of two theories is true can they be compared in terms of the suggested definition of versimilitude.This note was written when the author was visiting the Groupe de Recherche en Épistémologie Comparative (Université du Québec à Montréal).     

Mini-Review; Stress Genes: An Introductory Overview

Molecular sequence data, made available in the last 15 years or so, have led to the classification of living cells into three phylogenetic domains: Bacteria, Archaea, and Eucarya. All the organisms that have been tested belonging to either domain were capable of mounting a stress response with essentially the same characteristics, regardless of the stressor. The protagonists in the cell's stress response are the stress genes and their protein products. Some of the latter are molecular chaperones. Under physiological conditions, these chaperones aid other cellular proteins to fold properly and achieve a native -functional- configuration, and to translocate from the place of synthesis to the cell's locale in which they will operate. In a stressed cell, the stress proteins that are chaperones protect other molecules from denaturation and help those partially damaged to regain a functional configuration. Thus, cell death is avoided and recovery is enhanced. The study of stress genes and proteins has progressed considerably in organisms belonging to the domains Bacteria and Eucarya. Less is known about the archaeal stress genes. Here, research with an organism from the Archaea is discussed, focusing on the stress genes of the hsp70 (dnaK) locus. Future perspectives for basic and applied research within the health sciences and biotechnology industries are presented.     

Dissociation between Categorical and Coordinate Spatial Computations: Modulation by Cerebral Hemispheres, Task Properties, Mode of Response, and Age

Kosslyn suggested a dissociation of two kinds of spatial representations: categorical and coordinate, the former computed by the left hemisphere and the latter by the right hemisphere. In addition, with practice, a “categorization” of the coordinate computation would appear. These suggestions resulted largely from an experiment, replicated by others, in which the subjects had to estimate the relative position of a dot and a line by giving an oral response, and feedback was provided. The present series of five experiments was an attempt to test whether this finding could be generalized, under several methodological manipulations, some of which have already been used by researchers in separate studies. In the five experiments, accuracy was a more contributive dependent variable than correct latencies, and practice effects on the task × field interaction were not verified. Experiments 1–3 concerned the kind of response. When a manual instead of an oral response was required (Experiment 1;n= 32 Ss), the expected dissociation was observed (as well as when the latency of responses made by the right hand were studied). When the number of oral responses was increased from two (a binary choice) to eight, the dissociation was still observed for accuracy but disappeared when a more liberal criterion of accuracy was used to reduce the considerable task effect (Experiment 2;n= 32 Ss), or when response requirements were equated for both tasks (Experiment 3;n= 32 Ss). In Experiment 4 (n= 32 Ss), a manual response was called but the feedback was removed and the task dissociation disappeared. Finally, the task dissociation observed in Experiment 1 was not verified when a sample of elderly subjects was enrolled (Experiment 5;n= 32 Ss). However, age per se was the source of an interesting additional dissociation since only the coordinate computation was age sensitive. Our results suggest that the dissociation proposed by Kosslyn between the computation of categorical vs coordinate spatial relationships is highly unstable and sensitive to subtle methodological factors (vocal vs manual response, presence vs absence of feedback, binary vs “continous” response, age) which could preclude its general application.     

Measurement and the interpretation of quantum mechanics and relativity theory

The axiomatic approaches of quantum mechanics and relativity theory are compared with approaches in which the theories are thought to describe readings of certain measurement operations. The usual axioms are shown to correspond with classes of ideal measurements. The necessity is discussed of generalizing the formalisms of both quantum mechanics and relativity theory so as to encompass more realistic nonideal measurements. It is argued that this generalization favours an empiricist interpretation of the mathematical formalisms over a realist one.     

The equalitarian dogma revisited

Henry Garrett (1961), a president of the American Psychological Association, claimed that “the equalitarian dogma,” the belief that Blacks and Whites are genetically equal in cognitive ability, was the “scientific hoax of the century.” Since then, the dogma has become more ingrained, despite increased contrary evidence. The dogma has been perpetuated by intimidation as well as by pious thinking. Its long endurance is a scandal of great proportion and illuminates how science works, and sometimes does not. I discuss (a) current international data on race differences; (b) their genetic and evolutionary origins; (c) political fallout from my presentations; (d) corruption of scholarship that has occurred, illustrated partly by the example of Cyril Burt; and (e) what should be done to improve matters.