Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Neurodegen erative disorders such as Alzheimer’s disease (AD) are increasingly threatening public health. Most animal models of AD consist of transgenic mice that are usually housed singly or in unisexual groups in small barren cages. Such restricted environments, however, prevent the mice from showing a variety of speciesspecific behaviors and consequently may constrain comprehensive behavioral phenotyping. On the other hand, allowing the animals to freely organize their lives in a spacious physically and socially enriched environment makes behavioral phenotyping laborious and time consuming. Radio frequency identification (RFID) using a network of antennae and small glass-coated transponders labeling each individual allows for gathering spatiotemporal information about a large number of individuals in parallel. The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment.     

Beyond “accident-proneness”: Using Five-Factor Model prototypes to predict driving behavior

Research on the association between personality traits and driving behavior as well as accident involvement has produced mixed results. In order to obtain empirical evidence for a consistent relation between personality and driving behavior, a prototype approach based on the Five-Factor Model (FFM) was applied. In two samples of drivers, cluster analyses of FFM scales revealed three prototypes that replicate previous ones. The prototypes, labeled Resilient, Overcontrolled, and Undercontrolled, were found to differ reliably in accident involvement and driving behavior, indicating differential accident liability. Undercontrollers are the most problematic drivers followed by Resilients, whereas Overcontrollers most consistently obey traffic rules and drive accordingly.     

Family relations as perceived by emotionally disturbed and normal boys

The perception of feelings within the family of 9-13-year-old boys were studied. The purpose was to determine the sensitivity of the Family Relations Test (FRT) in discriminating between inpatients, outpatients, and normal controls. Both patient groups more frequently identified family members as sources of negative feelings than normal controls. Inpatients expressed more self-flattery and self-criticism and an absence of a reciprocal, positive relationship with their fathers. The FRT is only able to make a few quantitative differentiations between a clinical and a normal sample of boys but certain qualitative aspects of the responses were particularly noteworthy.     

Psychosis in German prisoners: Comparison of the clinical appearance of psychotic disorder of an imprisoned population with a not detained community group

Surveys confirm risk factors for the incarceration of patients with psychosis including homelessness and comorbidity. There is also agreement that severe psychosis can lead to violence. Data describing prisoners with psychosis in Germany are scarce. We aimed to compare patients with psychosis in a prison hospital and patients with psychosis in a community hospital. Demographic data were collected, as well as comorbidity in the form of substance dependence and a psychiatric assessment using the German version of the 18-item Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale (PANSS). In the prison hospital group more patients were homeless (17 versus 2%) and non-German (36 versus 4%). There were also more patients with substance dependence or abuse in the prison hospital group. The total scores of BPRS and PANSS were lower in the prison hospital group (BPRS, 43.8 versus 51.2; PANSS, 71.5 versus 83.7). We assume that social disintegration for mentally disturbed offenders prior to incarceration hindered effective treatment. To avoid further social disintegration and possible further deterioration of mental health status of released offenders, which may lead to reoffending after imprisonment, discharge management after release from prison should be improved.     

A Predictive Approach to Nonparametric Inference for Adaptive Sequential Sampling of Psychophysical Experiments

We present a predictive account on adaptive sequential sampling of stimulus-response relations in psychophysical experiments. Our discussion applies to experimental situations with ordinal stimuli when there is only weak structural knowledge available such that parametric modeling is no option. By introducing a certain form of partial exchangeability, we successively develop a hierarchical Bayesian model based on a mixture of Pólya urn processes. Suitable utility measures permit us to optimize the overall experimental sampling process. We provide several measures that are either based on simple count statistics or more elaborate information theoretic quantities. The actual computation of information theoretic utilities often turns out to be infeasible. This is not the case with our sampling method, which relies on an efficient algorithm to compute exact solutions of our posterior predictions and utility measures. Finally, we demonstrate the advantages of our framework on a hypothetical sampling problem.     

Schematic influences of rape myth acceptance on visual information processing: An eye-tracking approach

Schematic influences of rape myth acceptance (RMA) on visual information processing were studied. After reading a short text on a rape case, students viewed a “police photograph” of the plaintiff's living room, where the rape allegedly happened, while their eye-movements were recorded. The photograph contained two myth-consistent cues, one being expected in the situation (wine bottle and glasses), the other unexpected (poster of a nude male). Results of Study 1 (N = 60) showed that participants higher in RMA fixated the expected cue both earlier and less long, which may indicate hypervigilance and greater ease of processing, respectively. Higher RMA also predicted longer initial fixation of the unexpected cue. These processing differences mediated participants' verdicts and blame judgments. In Study 2 (N = 30), participants' level of RMA was manipulated experimentally via social norm feedback. This manipulation significantly affected eye-movement patterns for the expected myth-consistent cue. Results support the notion that RMA actively guides visual information processing of relevant stimuli.     

Not just another face in the crowd: Detecting emotional schematic faces during continuous flash suppression

To test whether threatening visual information receives prioritized processing, many studies have examined visual search for emotional schematic faces. Still, it has remained unclear whether negative or positive schematic faces are processed more efficiently. We used continuous flash suppression, a variant of binocular rivalry, to render single emotional schematic faces invisible and measured whether negative or positive faces have an advantage in accessing awareness. Across three experiments, positive faces were detected more quickly than negative faces. A fourth experiment indicated that this positive face advantage was unrelated to the valence of the face stimuli but due to the relative orientation of the mouth curvature and the face contour. These findings demonstrate the impact of configural stimulus properties on perceptual suppression during binocular rivalry and point to a perceptual confound present in emotional schematic faces that might account for some ambiguous results obtained with schematic face stimuli in previous studies. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Protecting Against Low‐Probability Disasters: The Role of Worry

We carry out a large monetary stakes insurance experiment with very small probabilities of losses and ambiguous as well as exact probabilities. Many individuals do not want to pay anything for insurance whether the probabilities are given exactly or are ambiguous. Many others, however, are willing to pay surprisingly large amounts. With ambiguity, the percentage of those paying nothing is smaller and the willingness to pay (WTP) of the other individuals larger than with exact probabilities. Comparing elasticities with ambiguity, we find that worry is much more important than subjective probability in determining WTP for insurance. Furthermore, when the ambiguous loss probability is increased by a factor of 1000, it has almost no effect on WTP. Copyright © 2011 John Wiley & Sons, Ltd.     

Fisher transformation based confidence intervals of correlations in fixed- and random-effects meta-analysis

Meta-analyses of correlation coefficients are an important technique to integrate results from many cross-sectional and longitudinal research designs. Uncertainty in pooled estimates is typically assessed with the help of confidence intervals, which can double as hypothesis tests for two-sided hypotheses about the underlying correlation. A standard approach to construct confidence intervals for the main effect is the Hedges-Olkin-Vevea Fisher-z (HOVz) approach, which is based on the Fisher-z transformation. Results from previous studies (Field, 2005, Psychol. Meth., 10, 444; Hafdahl and Williams, 2009, Psychol. Meth., 14, 24), however, indicate that in random-effects models the performance of the HOVz confidence interval can be unsatisfactory. To this end, we propose improvements of the HOVz approach, which are based on enhanced variance estimators for the main effect estimate. In order to study the coverage of the new confidence intervals in both fixed- and random-effects meta-analysis models, we perform an extensive simulation study, comparing them to established approaches. Data were generated via a truncated normal and beta distribution model. The results show that our newly proposed confidence intervals based on a Knapp-Hartung-type variance estimator or robust heteroscedasticity consistent sandwich estimators in combination with the integral z-to-r transformation (Hafdahl, 2009, Br. J. Math. Stat. Psychol., 62, 233) provide more accurate coverage than existing approaches in most scenarios, especially in the more appropriate beta distribution simulation model.