Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning

The adenosine A(2A) receptor (A(2A)R) is highly enriched in the striatum where it is uniquely positioned to integrate dopaminergic, glutamatergic, and other signals to modulate cognition. Although previous studies support the hypothesis that A(2A)R inactivation can be pro-cognitive, analyses of A(2A)R's effects on cognitive functions have been restricted to a small subset of cognitive domains. Furthermore, the relative contribution of A(2A)Rs in distinct brain regions remains largely unknown. Here, we studied the regulation of multiple memory processes by brain region-specific populations of A(2A)Rs. Specifically, we evaluated the cognitive impacts of conditional A(2A)R deletion restricted to either the entire forebrain (i.e., cerebral cortex, hippocampus, and striatum, fb-A(2A)R KO) or to striatum alone (st-A(2A)R KO) in recognition memory, working memory, reference memory, and reversal learning. This comprehensive, comparative analysis showed for the first time that depletion of A(2A)R-dependent signaling in either the entire forebrain or striatum alone is associated with two specific phenotypes indicative of cognitive flexibility-enhanced working memory and enhanced reversal learning. These selective pro-cognitive phenotypes seemed largely attributed to inactivation of striatal A(2A)Rs as they were captured by A(2A)R deletion restricted to striatal neurons. Neither spatial reference memory acquisition nor spatial recognition memory were grossly affected, and no evidence for compensatory changes in striatal or cortical D(1), D(2), or A(1) receptor expression was found. This study provides the first direct demonstration that targeting striatal A(2A)Rs may be an effective, novel strategy to facilitate cognitive flexibility under normal and pathologic conditions.     

Another Side to Downsizing: Survivors' Behavior and Self-Affirmation

Downsizing is one of the terms used to describe the efforts of companies to gain a competitive edge. The effects of global competition, mergers, market saturation, and automation are forcing the streamlining of the American workforce. This study addresses the gap in empirical data on the effects of self-affirmation opportunities to employee survivors and victims. Specifically, the conceptual model developed in this research examines the interactive effects of self-affirmation and the perception of procedural justice, distributive justice, and job insecurity on the induced psychological states of the individuals involved with companies engaged in downsizing. The conceptual model suggests that layoffs have an impact on the induced psychological states of the individuals affected. At play in the model is the moderating variable of re-affirmation. This, in turn, will affect the attitudes and work behaviors of those same individuals and their ability to maintain their self-image. Specific recommendations to management, based on these findings, conclude the study.     

Effects of response selection on the task repetition benefit in task switching

A task switch typically leads to worse performance than a repetition does. This shift cost can be reduced with sufficient task preparation time, but a residual cost usually remains. We propose that a large part of this residual cost is caused by an activation bias produced by response selection processes in the preceding trial. In our experiments, we manipulated response selection requirements using a go/no-go methodology. The residual shift cost disappeared after no-go trials, suggesting that response selection is crucial to establish an activation bias for the current category-response rules and that this bias persists into the next trial. A comparison with a go-only group confirmed this analysis by revealing no differences in preparatory strategy due to the inclusion of no-go trials. In addition, no-go trials had no significant effects on subsequent trials in a single-task experiment, suggesting that no-go trials are not coded as a task different from go trials and that there is no inhibition of the prepared task in a no-go trial. We thus conclude that a persisting activation bias of response rules plays a major role in task switching.     

Charakterpathologie – Persönlichkeitsorganisationen – Strukturniveaus

Following the recent development of special treatment for people with defective ego structures, the diagnosis of ego structures has become highly relevant. Four models, developed during the last 40 years for the differentiation of particular levels of the ego structure are presented: the classification of character pathology (Kernberg 1966), the personality organisations (Kernberg 1977 and 1996), the structure axis of the OPD (Operationalized Psychodynamic Diagnosis 1996) and the personality organisations of the STIPO (2006). Because the levels of character pathology, the personality organisations as well as the structural levels of the OPD are widely used and the last two often even in parallel, it is worthwhile comparing them concerning their strengths, weaknesses and compatibility. It turns out that especially the categories between the neurotic and the borderline personality organisation (Kernberg 1977) show significant differences. The fact that the OPD as well as the STIPO pay much more attention to these levels as the models of personality organisations also do, is to be considered because of its great clinical significance as an advantageous innovation. In addition, both instruments offer the possibility to assign different structural levels to particular dimensions and, due to their operationalization, assure comparability and allow change measurement.     

Attention,consciousness, and the semantics of questions

Attention influences the character of conscious perceptual experience in intricate and surprising ways, including our experience of contrast, space, and time. These patterns of influence have been argued to cause trouble for the attractive thesis that differences in the character of conscious experience flow from differences in what we represent (Block 2010). I present a novel theory of the functional role of attention that has the resources for a systematic representationalist account of these phenomena. On the erotetic theory of attention, we bring an interest to the task of perception, captured as a question we seek to answer. Questions, as understood here, are contents that cognitive systems can represent rather than sentences. We process perceptual input as a putative answer to our question in a way that is modulated by attentional focus; attentional focus aims to pick out something that matches what our question is “about.” In certain cases, this yields a form of predictive coding: if the contribution of focus matches what our question is about, we take it to select one of the possible answers we are entertaining, even though our perceptual input by itself does not supply a full answer. The proposed account also provides a new account of the phenomenology of salience.     

Comparing Correlates of Civic Engagement Between Immigrant and Majority Youth in Belgium,Germany, and Turkey

Drawing on data from a large-scale international project, this research examined predictors of civic engagement between immigrant (n = 599) and majority youth (n = 1,027) in Belgium, Germany, and Turkey. In all three countries immigrants were found to be more civically engaged than their majority peers. Further, based on the assumptions of the civic voluntarism model, civic engagement was predicted by resources, social experiences, and psychological engagement (i.e., internal political efficacy). The results showed that predictors differed by ethnic background. Although internal political efficacy beliefs were only found to be a significant predictor of civic engagement among majority youth, involvement in social networks was found to be a more meaningful predictor among immigrant youth. These results are discussed in terms of theoretical and practical implications.     

Motive Arousal Without Pictures? An Experimental Validation of a Hybrid Implicit Motive Test

Pictures are widely used as stimuli in implicit motive tests. Hybrid forms of such tests present pictures and declarative statements underneath pictures. Some authors have argued that explicitly declaring agreement with motive-related statements presented underneath pictures might shift the validity of such tests from capturing less implicit motives to more explicit motives. If that is the case, pictures as elicitors of implicit motives might become less relevant. Adopting the views on validity presented by Borsboom, Mellenbergh, and van Heerden (2004 Borsboom, D., Mellenbergh, G. J., &; van Heerden, J. (2004). The concept of validity. Psychological Review, 111, 1061–1071. doi:10.1037/0033-295X.111.4.1061[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and Bornstein (2011 Bornstein, R. F. (2011). Toward a process-focused model of test score validity: Improving psychological assessment in science and practice. Psychological Assessment, 23, 532–544. doi:10.1037/a0022402[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), as well as item generation theory, we investigated whether the availability of pictures in hybrid motive tests causally affects test scores. To this end, we administered the Multi-Motive Grid (MMG; Sokolowski, Schmalt, Langens, &; Puca, 2000 Sokolowski, K., Schmalt, H.-D., Langens, T. A., &; Puca, R. M. (2000). Assessing achievement, affiliation, and power motives all at once: The Multi-Motive-Grid (MMG). Journal of Personality Assessment, 74, 126–145. doi:10.1207/S15327752JPA740109[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]), as an example of a hybrid motive test, either with or without pictures to 108 participants. Results revealed that the availability of pictures had no effect on 3 out of 6 test scores. Furthermore, eliminating pictures had only inconsistent effects on correlations with a test of explicit motives. We conclude that pictures might not unanimously elicit motives in implicit motive tests that use declarative statements as response options.     

Selling with technology: understanding the resistance to mobile sales assistant use in retailing

The rise of online competitors and increasingly well-informed customers have spurred stationary retailers to take measures to increase the quality of face-to-face selling as a key differentiator. Mobile sales assistants (MSAs) represent an intensively discussed technological approach to address these challenges in the salesperson–customer dyad. However, in many cases, salespeople do not or only sporadically use MSAs. Prior research provides inadequate answers as to why this is the case, as extant technology acceptance and resistance theories have limited applicability to MSAs. To address these research gaps, the authors conduct a qualitative, theory-building approach and identify 21 factors associated with resistance. In a subsequent quantitative survey study, they validate these factors and refine their conceptual structure. The results show that several largely unknown factors are associated with salespeople’s resistance to MSA use: The three higher-order constructs, ‘incongruence’, ‘relationship deterioration’, and ‘operational imperfection’, are newly introduced to the literature on technology resistance. The findings extend prior technology acceptance and resistance theories and provide comprehensive insights for retail managers.