Is implicit sequence learning impaired in schizophrenia? A meta-analysis

Cognition in schizophrenia seems to be characterized by impaired performance on most tests of explicit or declarative learning contrasting with relatively intact performance on most tests of implicit or procedural learning. At the same time there have been conflicting results for studies that have used the Serial Reaction Time (SRT) task to examine implicit learning in people with schizophrenia. In the present research, we used meta-analysis to clarify whether or not people with schizophrenia show impaired performance on the SRT task. A systematic review found nine studies published in peer review journals that had each compared the performance of a group of people with schizophrenia with healthy controls on the standard SRT task or a variant of it. The resulting meta-analysis represented the responses of 205 participants with schizophrenia and 159 healthy controls on the SRT task. The analysis found that participants with schizophrenia perform less well than controls reflected by a pooled effect size of 0.51. A secondary analysis of all nine studies found that they all reported a point estimate of the change in reaction time between sequence and random trials that was greater for the controls. We conclude that there is a moderate impairment in implicit sequence learning among people with schizophrenia and speculate on the implications of this for understanding this disorder. Suggestions for improving the methodological quality and statistical reporting of studies of this topic are made.     

The relative success of recognition-based inference in multichoice decisions

The utility of an "ecologically rational" recognition-based decision rule in multichoice decision problems is analyzed, varying the type of judgment required (greater or lesser). The maximum size and range of a counterintuitive advantage associated with recognition-based judgment (the "less-is-more effect") is identified for a range of cue validity values. Greater ranges of the less-is-more effect occur when participants are asked which is the greatest of m choices ( m > 2) than which is the least. Less-is-more effects also have greater range for larger values of m . This implies that the classic two-alternative forced choice task, as studied by Goldstein and Gigerenzer (2002) , may not be the most appropriate test case for less-is-more effects.     

Sound source location modulates the irrelevant-sound effect

Participants memorized lists of visually presented digits in silence or while ignoring distractor sounds that either came from the front and thus from the direction in which participants' attention was oriented, or from behind. Distractor sounds impaired recall performance, but the largest impairment was observed when the sound source was directionally close to the frontal visual target display. The results are consistent with the assumption of cross-modal attentional links in models of attention, and they are problematic for explanations of the irrelevant-sound effect within working memory models that do not specify an explicit role of attention in the maintenance of information for immediate serial recall.     

Neuropsychological Effects of Brain Arteriovenous Malformations

Brain arteriovenous malformations (AVM's) are developmental, chronic lesions that provide unique information about the human brain and can be a useful model for neuroscientists to study cerebral reorganization and hemodynamics. We review the neuroanatomy, epidemiology, natural history, imaging and treatment of brain AVMs, and provide a model with which to better understand neuropsychological functioning and brain reorganization. We suggest that future studies must exclude ruptured AVMs if they wish to further explain focal neurological/cognitive deficits associated with this neurovascular anomaly.     

Visual word recognition without central attention: Evidence for greater automaticity with greater reading ability

The present study examined individual differences in the automaticity of visual word recognition. Specifically, we examined whether people can recognize words while central attention is devoted to another task and how this ability depends on reading skill. A lexical-decision Task 2 was combined with either an auditory or visual Task 1. Regardless of the Task 1 modality, Task 2 word recognition proceeded in parallel with Task 1 central operations for individuals with high Nelson-Denny reading scores, but not for individuals with low reading scores. We conclude that greater lexical skill leads to greater automaticity, allowing better readers to more efficiently perform lexical processes in parallel with other attention-demanding tasks.     

Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex

Surgical disconnection of the frontal cortex and inferotemporal cortex severely impairs many aspects of visual learning and memory, including learning of new object-in-place scene memory problems, a monkey model of episodic memory. As part of a study of specialization within prefrontal cortex in visual learning and memory, we tested monkeys with bilateral ablations of ventrolateral prefrontal cortex in object-in-place scene learning. These monkeys were mildly impaired in scene learning relative to their own preoperative performance, similar in severity to that of monkeys with bilateral ablation of orbital prefrontal cortex. An analysis of response types showed that the monkeys with lesions were specifically impaired in responding to negative feedback during learning: The post-operative increase in errors was limited to trials in which the first response to each new problem, made on the basis of trial and error, was incorrect. This perseverative pattern of deficit was not observed in the same analysis of response types in monkeys with bilateral ablations of the orbital prefrontal cortex, who were equally impaired on trials with correct and incorrect first responses. This may represent a specific signature of ventrolateral prefrontal involvement in episodic learning and memory.     

The 2007 Birmingham Agreed Syllabus for Religious Education: a new direction for statutory religious education in England and Wales

The aim of this article is to introduce and summarise the main feature of the new Birmingham City Council Agreed Syllabus for Religious Education (2007 Birmingham City Council (BCC). 2007. Agreed Syllabus for Religious Education, Birmingham: City Council.  [Google Scholar]), consider the relevance of its commitments and conclusions to ongoing debates within British religious education, and, finally, offer some kind of provisional assessment of its strengths and worth. By way of introduction, attention is given both to the mounting controversy that currently attends British religious education, which has given rise to conflicting opinions and estimates of its achievements and value, and to the historical role and legal status of agreed syllabuses within English and Welsh education.     

White matter hyperintensities and working memory: an explorative study

White matter hyperintensities (WMH) are commonly observed in elderly people and may have the most profound effect on executive functions, including working memory. Surprisingly, the Digit Span backward, a frequently employed working memory task, reveals no association with WMH. In the present study, it was investigated whether more detailed analyses of WMH variables and study sample selection are important when establishing a possible relationship between the Digit Span backward and WMH. To accomplish this, the Digit Span backward and additional working memory tests, WMH subscores, and cardiovascular risk factors were examined. The results revealed that performance on the Digit Span backward test is unrelated to WMH, whereas a relationship between other working memory tests and WMH was confirmed. Furthermore, a division between several white matter regions seems important; hyperintensities in the frontal deep white matter regions were the strongest predictor of working memory performance.