Combining Information for Quantitative Decision‐making in Drug Development

Taking decisions during the development of a new drug requires combining many and varying pieces of information. The interconnections between these different pieces of information are often only partially known and in some cases merely conjectured. Despite this uncertainty, decisions must be taken – often with regard to the balance of risk and benefit – in order to make progress. A clear, consistent and efficient methodology for describing the structure of a project and the comprehensive state of knowledge at any point in time is required in order to add transparency to the decision process. A viable methodology must allow for a natural characterization of the uncertainty inherent in the drug development process and a relatively easy implementation. We present a possible solution that satisfies these requirements. The foundation of the proposed approach is based on a beta‐binomial update mechanism well known in Bayesian statistics. This work provides a consistent framework for solving hierarchical multicriteria decision problems. Copyright © 2014 John Wiley & Sons, Ltd.     

Dynamics of mental activity

Motivated by neuronal modeling, our development of the mathematical foundations of consciousness in [W. Miranker, G. Zuckerman, Mathematical Foundations of Consciousness, J. Appl. Logic (2009)] (M-Z) was characterized by an axiomatic theory for consciousness operators that acted on the collection of all sets. Consciousness itself was modeled as emanating from the action of such operators on the labeled decoration of a graph, the latter set theoretic construct given the characterization of experience. Since mental activity (conscious and unconscious) is a time dependent process, we herein develop a discrete time dependent version of the theory. Specification of the relevant mental dynamics illuminates and expands the development of the mathematical framework in (M-Z) upon which our study of consciousness rests. This framework is an abstraction of neural net modeling.We review the Aczel theory for decorating labeled graphs, in particular that theory's application to the (M-Z) foundations. The relevant neuronal modeling concepts and terminology are also reviewed. A number of examples are presented. Then an extension of our considerations from graphs to multigraphs is made, since the latter represent a more accurate model of neuronal circuit connectivity. The dynamics are crafted for non-well-founded constructs by development of a hierarchy of systems, starting with the McCulloch–Pitts neuronal voltage input–output relations and building to a dynamics for the cognitive notions of memes and themata; these latter corresponding to aspects of decorations of labeled graphs associated with neural networks. We conclude with a summary and discussion of the semantics of the cognitive features of our development: memes, themata, qualia, consciousness operators, awareness field.     

Narratives of Mastery and Resistance: Lay Ethics of Nanotechnology

This paper contributes towards a lay ethics of nanotechnology through an analysis of talk from focus groups designed to examine how laypeople grapple with the meaning of a technology ‘in-the-making’. We describe the content of lay ethical concerns before suggesting that this content can be understood as being structured by five archetypal narratives which underpin talk. These we term: ‘the rich get richer and the poor get poorer’; ‘kept in the dark’; ‘opening Pandora’s box’; ‘messing with nature’; and ‘be careful what you wish for’. We further suggest that these narratives can be understood as sharing an emphasis on the ‘giftedness’ of life, and that together they are used to resist dominant technoscientific and Enlightenment narratives of control and mastery which are encapsulated by nanotechnology.     

Research into therapists’ perceptions of therapeutic change using vignettes and aMSN messenger

This article describes a research approach to investigating the ways in which therapists understand the nature of therapeutic change. The research was based in qualitative, narrative approaches to in-depth analysis of vignettes provided by drama therapists. The article describes the approach to the generation of data through the internet by aMSN messenger. It reports on the approach taken to the analysis of data along with samples from the findings.     

Parental grief of a perinatal loss: A comparison of individual and relationship variables

Abstract

This study focuses on the comparison of individual variables of bereavement, depression, and stress with variables associated with the couple relationship, including cohesion, adaptability, communication, satisfaction, and partner support. In total, 24 couples completed self-report instruments within 2 weeks after a miscarriage. Mothers had significantly stronger grief reactions than fathers. Fathers and mothers perceived their relationships similarly as highly functional. Except for mothers' depression and their satisfaction with the couple relationship, the correlations between individual and relationship variables were rather weak. Implications of the results for family professionals are discussed.     

Unsinnig: A Reply to Hutto∗

Abstract

In the late 1930s Heidegger makes allusions to ‘the wild’ and ‘the mild’ in connection with a human liberation that he understands as a steadfast response to the claim that historical being (Seyn) makes upon us. The following paper elucidates these allusions in terms of the overturning of metaphysics that they entail.     

A Multitrait Multimethod Measurement Approach to the Traits (or States) of Anxiety,Depression and Hostility

This study tested the convergent and discriminant validities of various psychological techniques used for the measurement of the affects of anxiety, depression and hostility. The subjects were 29 psychiatric patients and 25 normal controls, all males. Subjects were interviewed and rated for the three affects and given an extensive battery of tests. Anxiety and depression measures from ratings, checklists, and questionnaires demonstrated good convergent validity but poor discriminant validity. The projective methods did not demonstrate much convergent validity. Hostility was separable from anxiety and depression but the tests showed poor convergent validity for hostility. In the normals, fantasy hostility (TAT) and admitted hostility (Multiple Affect Adjective Check List) showed some convergence, but in the patients there was no congruence between these two levels.     

Primal Scene Fantasies and Cathexis of Self as Reflected in the Psychoanalytic Situation

Close parallels are pointed out between the Jewish and the psychoanalytic way of structuring central patterns in their respective thinking. The central power in existence is The Undescribable One or That which is undescribable. The primary task of enlighted man is to remember and hope. An arch is raised from the past into the future and the creation appears as a so-far unfinished process—the final answers will be given first with the return of the profet Elias and Messiah. Thus, the preliminary nature of all our attempts at solutions is underscored.     

Dreams in Child Psychoanalysis

More than six decades after Freud's death, psychoanalysts are certainly not more unified in their view of the concept of the unconscious—its structure and its way of working—than in ‘the good old days’. Challenges are facing psychoanalysis from many perspectives, urging psychoanalysts to continuously reconsider their theoretical grounds. This paper pursues three lines of argumentation concerning the Unconscious. The first line concerns the relation to neuroscience and this paper suggests the concept of background feelings (Damasio) as a contribution to another understanding of deficits in the psychoanalytic relationship. The second line concerns the relation to cognitive semiotics, and here, the paper stresses the concept of basic image sehemata as a possible link between the subject's pre-reflective awareness of the other and the internal world of phantasy. The third line pursues a concept of the analytic interpretation which is close to the Freudian idea that psychoanalysis is the communication between two Unconscious, and, consequently, that the psycho-analytic interpretation is not per se a conscious act.     

ON THE PROBLEM OF ENVY

It is easy for modern man to draw up outlines of a future ideal society where people are good and happy and no social discord prevails anymore It is probably even easier to criticize mistakes of the past, to hold our forefathers responsible for social wrongs and human suffering. The greatest difficulty lies in realizing the limitations of our own conception of the world and of our own objectives. Each generation tends to be blind to its own mistakes, but becomes later, in its turn, the object of the judgment of history.