The importance of conduct problems and depressive symptoms in predicting adolescent substance use

The current study assessed the relative importance of conduct problems and depressive symptoms, measured at two ages (11 and 15), for predicting substance use at age 15 in an unselected birth cohort of New Zealand adolescents. Among males, when the relative predictive utility of both conduct problems and depressive symptoms was assessed, only pre-adolescent depressive symptoms were found to predict multiple drug use 4 years later. No predictive relation was found between early symptomatology and later substance use among females. The strongest association between predictors and substance use emerged between age 15 multiple drug use and concurrent conduct problems for both males and females. Finally, both conduct problems and depressive symptoms at age 15 were also found to be associated with concurrent self-medication among females.This work was supported by USPHS grants MH-43746 and MH-45070 from the Antisocial and Violent Behavior Branch of the National Institute of Mental Health to Terrie Moffitt. Bill Henry was funded by a Fulbright Travel Award. The Dunedin Multidisciplinary Health and Development Research Unit is supported by the Medical Research Council and Health Research Council of New Zealand. Appreciation is expressed to the interviewers who collected the data, and to the young New Zealanders who were members of the sample.     

Revaluation manipulations produce emergence of underselected stimuli following simultaneous discrimination in humans

Stimulus overselectivity occurs when only one of potentially many aspects of the environment controls behaviour. In four experiments, human participants were trained and tested on a trial-and-error simultaneous discrimination task involving two two-element compound stimuli. Overselectivity emerged in all experiments (i.e., one element from the reinforced compound controlled behaviour at the expense of the other). Following revaluation (extinction) of the previously overselected stimulus, behavioural control by the underselected stimulus element emerged without any direct training of that stimulus element. However, while a series of extinction manipulations targeting the revaluation of the overselected stimulus produced differential extinction of that stimulus, they did not result in differential emergence of the previously underselected stimuli. The results are discussed with respect to the theoretical implications for attention-based accounts of overselectivity.     

Combining Information for Quantitative Decision‐making in Drug Development

Taking decisions during the development of a new drug requires combining many and varying pieces of information. The interconnections between these different pieces of information are often only partially known and in some cases merely conjectured. Despite this uncertainty, decisions must be taken – often with regard to the balance of risk and benefit – in order to make progress. A clear, consistent and efficient methodology for describing the structure of a project and the comprehensive state of knowledge at any point in time is required in order to add transparency to the decision process. A viable methodology must allow for a natural characterization of the uncertainty inherent in the drug development process and a relatively easy implementation. We present a possible solution that satisfies these requirements. The foundation of the proposed approach is based on a beta‐binomial update mechanism well known in Bayesian statistics. This work provides a consistent framework for solving hierarchical multicriteria decision problems. Copyright © 2014 John Wiley & Sons, Ltd.     

Narratives of Mastery and Resistance: Lay Ethics of Nanotechnology

This paper contributes towards a lay ethics of nanotechnology through an analysis of talk from focus groups designed to examine how laypeople grapple with the meaning of a technology ‘in-the-making’. We describe the content of lay ethical concerns before suggesting that this content can be understood as being structured by five archetypal narratives which underpin talk. These we term: ‘the rich get richer and the poor get poorer’; ‘kept in the dark’; ‘opening Pandora’s box’; ‘messing with nature’; and ‘be careful what you wish for’. We further suggest that these narratives can be understood as sharing an emphasis on the ‘giftedness’ of life, and that together they are used to resist dominant technoscientific and Enlightenment narratives of control and mastery which are encapsulated by nanotechnology.     

Research into therapists’ perceptions of therapeutic change using vignettes and aMSN messenger

This article describes a research approach to investigating the ways in which therapists understand the nature of therapeutic change. The research was based in qualitative, narrative approaches to in-depth analysis of vignettes provided by drama therapists. The article describes the approach to the generation of data through the internet by aMSN messenger. It reports on the approach taken to the analysis of data along with samples from the findings.     

Parental grief of a perinatal loss: A comparison of individual and relationship variables

Abstract

This study focuses on the comparison of individual variables of bereavement, depression, and stress with variables associated with the couple relationship, including cohesion, adaptability, communication, satisfaction, and partner support. In total, 24 couples completed self-report instruments within 2 weeks after a miscarriage. Mothers had significantly stronger grief reactions than fathers. Fathers and mothers perceived their relationships similarly as highly functional. Except for mothers' depression and their satisfaction with the couple relationship, the correlations between individual and relationship variables were rather weak. Implications of the results for family professionals are discussed.     

Unsinnig: A Reply to Hutto∗

Abstract

In the late 1930s Heidegger makes allusions to ‘the wild’ and ‘the mild’ in connection with a human liberation that he understands as a steadfast response to the claim that historical being (Seyn) makes upon us. The following paper elucidates these allusions in terms of the overturning of metaphysics that they entail.