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181.
Susanna Zarafonitis Michael Wagner Verena Pützfeld Julia Berning Birgit Janssen Petra Decker Ronald Bottlender Hans-Jürgen M?ller Wolfgang Gaebel Wolfgang Maier Joachim Klosterk?tter Andreas Bechdolf 《Psychotherapeut》2012,57(4):326-334
Background
So far only few studies are available which have evaluated the effectiveness of psychoeducation for individuals at risk of psychosis in the early initial prodromal state (EIPS) whereas the benefit of psychoeducation in psychotic patients has been repeatedly confirmed. Thus the aim of this study was to investigate the effect of psychoeducation in individuals with increased risk of psychosis in the EIPS.Method
A total of 128 help-seeking outpatients in the EIPS participated in a randomized controlled multicentre trial of 12 months of either psychoeducation as part of an integrated psychological intervention (IPI) or supportive counseling (SC). The time to transition to psychosis at 12-month and 24-month follow-up as well as the social adjustment at baseline, time of transition or post-treatment by means of the social adjustment scale (SAS?II) were assessed.Results
The IPI was superior to SC in preventing progression to psychosis at 12-month (3.2% versus 16.9%, p?=0.008) and 24-month follow-up (6.3% versus 20.0%, p?=0.019). Both treatments resulted in significant pre-post improvements in SAS?II with no significant differences between the two groups.Conclusions
Psychoeducation as part of an integrated intervention is effective for preventing the onset of psychosis over a 24-month time period in people in an EIPS. Moreover patients at risk of developing first episode psychosis seem to benefit from a specific psychoeducational intervention in the context of other treatments as well as from SC. 相似文献182.
Peters S Grunwald N Rümmele P Endlicher E Lechner A Neumann ID Obermeier F Reber SO 《Stress (Amsterdam, Netherlands)》2012,15(4):403-415
Patients with inflammatory bowel diseases (IBDs) have a higher risk of developing colorectal cancer (CRC) than the general population. Furthermore, chronic psychosocial stress increases the likelihood of developing IBD and multiple types of malignant neoplasms, including CRC. Here, for the first time, we investigate the effects of chronic psychosocial stress in male mice on an artificially induced CRC, by employing the chronic subordinate colony (CSC) housing paradigm in combination with the reliable azoxymethane (AOM)/dextran sodium sulfate (DSS) CRC model. Colonoscopy revealed that CSC mice showed accelerated macroscopic suspect lesions. In addition, more CSC mice developed low-grade dysplasia (LGD) and/or high-grade dysplasia (HGD) in the colonic tissue compared to the single-housed control mice (SHC). CSC mice showed an increased number of Ki67+ and a decreased number of terminal deoxynucleotidyl transferase dUTP nick end labeling epithelial cells in colonic tissue. Colonic liver receptor homolog-1 (LRH-1), cyclooxygenase II (COXII), tumor necrosis factor, forkhead box P3 (FoxP3) mRNA as well as colonic ?-catenin, COXII, and LRH-1 protein expression were also increased in CSC compared with SHC mice. Although the number of CD4+ Th cells was increased, a tendency toward a decreased colonic interferon-γ (IFN-γ) mRNA expression was observed. Furthermore, despite an increased percentage of CD3+ cells and CD3+/FoxP3+ double-positive cells within mesenteric lymph node cells of CSC mice, IFN-γ secretion from these cells was unaffected. Altogether, our results suggest that chronic psychosocial stress increases the risk for AOM/DSS-induced and, thus, inflammation-related CRC. Finally, assessment of additional time points may test whether the shift from tumor-protective Th1 cell to regulatory T-cell immunity represents a consequence of increased carcinogenesis or a causal factor involved in its development. 相似文献
183.
Roger A. Boothroyd Anne D. Kuppinger Mary E. Evans Mary I. Armstrong Marleen Radigan 《Journal of child and family studies》1998,7(3):353-376
Respite care is widely believed to be an important support service for families raising a child with a disability. We report the findings of a respite care utilization study conducted within the context of a larger research and demonstration project examining three models of intensive, in-home services for children experiencing psychiatric crises. Respite care, both in-home and out-of-home, was a support service available to families in two of the three study conditions. Overall, 34% of 146 eligible families used in-home and or out-of-home respite care. Utilization was lower than the estimates developed prior to implementation, prompting an inquiry at the end of the first project year designed to maximize use and to gather more information on caregiver and service provider attitudes toward respite care. The inquiry included caregiver and provider focus groups, surveys, and enhanced data collection and analysis. Caregiver interviews indicated that many families did not fully understand what it meant to receive respite care or even that it was available to them. A comparative analysis of respite care users and non-users revealed that respite care users were more likely to have younger children, children who had a greater number of assessed functional impairments, and fewer social supports. Respite care users also reported greater difficulty managing their children's difficult behaviors. 相似文献
184.
The purpose of this study was to examine the relation between motor development and spatial cognition. The sample was 20 children with Spina bifida (M age: 11.4 yr., SD = 1.7) and 20 healthy children as controls (M age: 11.8, SD = 1.8 yr.). An experimental assessment of motor development in spatial cognition in a simulated virtual maze by school-age children is lacking. In this study children with Spina bifida, who were impaired in walking since birth, completed four visuospatial tasks in a small-scale space (Mental Rotation, Water-Level Task, Embedded Figures Test, Visual Short-term Memory Test), and a spatial behaviour and knowledge task in a virtual maze. These children showed poorer performance than children in the control group on most measures. The results are discussed with respect to theoretical implications and further research. 相似文献
185.
The present study investigates whether the maternal interaction style is related to 6-month-old infants' action interpretation. We tested 6-month-olds ability to interpret an unfamiliar human action as goal-directed using a modified version of the paradigm used by Woodward, A. L. (1999). Infant's ability to distinguish between purposeful and non-purposeful behaviours. Infant Behavior & Development, 22, 145-160 and Király, I., Jovanovic, B., Prinz, W., Aschersleben, G., & Gergely, G. (2003). The early origins of goal attribution in infancy. Consciousness & Cognition, 12, 732-751. Additionally, all infants and their mothers participated in a free play situation to assess maternal interaction styles as measured by the CARE-Index. According to mothers' distinct interaction styles, infants were divided into three groups. Results suggest that at 6 months of age infants of mothers with a modestly controlling interaction style are better at interpreting a human action as goal-directed than infants of sensitive and relative unresponsive mothers. The ability to understand human action as goal-directed might be a corollary of an adaptive strategy in infancy. 相似文献
186.
Adults assess precisely the center of mass (CM) of single-bodied objects and choose grasping points that span an axis through or close to the center of mass when lifting them. The present study examined how children and adults assess the CM when lifting two-bodied objects (barbells) and how this ability develops. Four- to five-year olds, 6- to 7-year olds, 9- to 11-year olds and adults were required to grasp and lift symmetrically and asymmetrically proportioned miniature barbells and their grasping points were recorded. While the 4- to 5-year olds grasped near the center of the barbell, accuracy of assessing the correct CM improved linearly with age. Although adults grasped close to the CM, their CM determination follows only an approximation of the physical law. 相似文献
187.
188.
John C. J. Hoeks Gisela Redeker Petra Hendriks 《Journal of psycholinguistic research》2009,38(3):221-235
Two studies investigated the effects of prosody and pragmatic context on off-line and on-line processing of sentences like
John greeted Paul yesterday and Ben today. Such sentences are ambiguous between the so-called ‘nongapping’ reading, where John greeted Ben, and the highly unpreferred ‘gapping’ reading, where Ben greeted Paul. In the first experiment, participants listened to dialogues and gave a speeded response as to which reading of an ambiguous
target sentence first comes to mind. In the second experiment, they also responded to a visual probe that was presented during
the presentation of the ambiguous target. The results show that context and prosody have independent and strong effects on
both on-line processing and off-line interpretation of gapping; in the right combination they can make gapping as easy as
the normally preferred nongapping reading. 相似文献
189.
An increasing number of people have difficulties in limiting private PC/internet use. Especially, MMORP games (massively multiplayer online role-playing games) like ?World of Warcraft“, action games (?Ego-shooters“) like ?Counterstrike“, surfing and chatting are very time-consuming and for some people can reach a pathological level. When real life disappears from a person’s sight and he is almost permanently focusing on the virtual world, we speak about ?pathological PC/internet use“. The great amount of time spent online for non-work or non-school related purposes is one major symptom. In the AHG clinic Münchwies an in-patient program for pathological PC/internet users has been developed. which focuses on group therapy and is based on integrative cognitive behavioural therapy. Difficulties with motivation, compliance, interaction, attachment organisation and self-structuring of those patients are addressed in addition to the core symptoms. A major goal is to centre the patient’s activities and interests back towards real life in order to establish functioning social-interactive relationships again and to reduce the PC/internet use strictly to professional and necessary private activities. 相似文献
190.
The present study was aimed at clarifying whether preattentive processing of heart cues results in biased perception of heart sensations in patients with congenital heart disease (ConHD) who are also highly trait anxious. Twenty-six patients with ConHD and 22 healthy participants categorized heart-related (heart rate) or neutral sensations (constant vibration) as either heart or neutral. Both sensations were evoked using a bass speaker that was attached on the chest of the participant. Before each physical sensation, a subliminal heart-related or neutral prime was presented. Biased perception of heart-sensations would become evident by a delayed categorization of the heart-related sensations. In line with the prediction, a combination of high trait anxiety and ConHD resulted in slower responses after a heart-related sensation that was preceded by a subliminal heart cue. Preattentive processing of harmless heart cues may easily elicit overperception of heart symptoms in highly trait anxious patients with ConHD. 相似文献