Behavioral and pharmacological treatments for tourette syndrome: A review

This article reviews the published treatment outcome research on pharmacological and behavioral treatments for Gilles de la Tourette syndrome (TS). Controlled group outcome studies of pharmacological treatments show about a 50–60% reduction in tics with haloperidol and pimozide and about a 20% reduction with clonidine. A controlled group outcome study and several within-subject design studies of behavioral treatments show about a 90% reduction in tics with habit reversal training. A large number of case studies generally confirm these results and also show benefits from other behavioral treatments such as relaxation training, self-monitoring, and contingency management. Clinical limitations of TS drugs are that they produce side effects in 50–85% of the patients and require continuous use, and long-term compliance with the medications is limited. The primary limitation of behavioral treatments is that they require a large initial time commitment. The methodological strengths of the controlled drug studies are the use of double-blind and group designs. For the behavioral studies, the strengths are rigorous recording and controlled within-subject designs.     

Sex steroids and human behavior: implications for developmental psychopathology

In a variety of mammalian species, prenatal androgens organize brain structures and functions that are later activated by steroid hormones in postnatal life. In humans, studies of individuals with typical and atypical development suggest that sex differences in reproductive and nonreproductive behavior derive in part from similar prenatal and postnatal steroid effects on brain development. This paper provides a summary of research investigating hormonal influences on human behavior and describes how sex differences in the prevalences and natural histories of developmental psychopathologies may be consistent with these steroid effects. An association between patterns of sexual differentiation and specific forms of psychopathology suggests novel avenues for assessing the effects of sex steroids on brain structure and function, which may in turn improve our understanding of typical and atypical development in women and men.     

The Matter of Religion and Science: Response to Huston Smith

Huston Smith's Why Religion Matters is the culminating reflections of one of the most respected religion scholars of our day. In this work, Smith sees modern society to be in the midst of a spiritual crisis. According to Smith, this crisis has been brought about by the advance of science and the inroads into what Smith calls the traditional worldview. While Smith's work is of some importance, I believe that several of its fundamental claims are mistaken. Smith often does not accurately portray the content of science and frequently conflates the actual practice of science with philosophical scientism. Smith wrongly blames science alone for the decline of religion among Western elites. His claim that all religions can be equivocally described in terms of the traditional worldview is also problematic. Despite this, Smith does have a clear conception of what the issues are in the relation between science and religion. It is my hope that these issues will continue to be taken seriously.     

Religion as Orienting Worldview

Religions are complex, and any attempt at defining religion necessarily falls short. Nevertheless, any scholarly inquiry into the nature of religion must use some criteria in order to evaluate and study the character of religious traditions across contexts. To this end, I propose understanding religion in terms of an orienting worldview. Religions are worldviews that are expressed not only in beliefs but also in narratives and symbols. More than this, religions orient action, and any genuine religious tradition necessarily is concerned with normative behavior, whether ethical or religious in character. Such an understanding of religion has several advantages, one of which is its natural relation to current forms of the science-religion dialogue. Not only can the findings of cognitive science and related areas inform us about the nature of religion; scientific discoveries also prove to be important for any religious synthesis that attempts to construct a worldview for the twenty-first century.     

“I Was Really, Really, Really Mad!” Children's Use of Evaluative Devices in Narratives About Emotional Events

Children (ages 3, 5, and 8 years, mostly White and middle-class) were asked to tell personal experience narratives about a time when they had been happy, surprised, and mad. Their explicit emotion labels as well as their use of linguistic forms of evaluation to convey emotion were assessed. Five-year-old boys were the most likely to explicitly label anger, while gender and age differences in explicit emotion labels were absent for the other two emotions. However, children used many more linguistic devices for providing evaluation than explicit emotion labels in their narratives. They also provided more with age, and they used more evaluative devices when talking about anger-arousing events than about happy or surprising events. The few gender differences suggested that 3-year-old girls may acquire earlier mastery of evaluative devices than do boys, especially references to emotional states.     

Influence of single and multiple onset distractors on visual search for singleton targets

In three experiments, we examined attentional and oculomotor capture by single and multiple abrupt onsets in a singleton search paradigm. Subjects were instructed to move their eyes as quickly as possible to a color singleton target and to identify a small letter located inside of it. In Experiment 1, taskirrelevant sudden onsets appeared simultaneously on half the trials with the presentation of the color singleton target. Response times (RTs) were longer when onsets appeared in the display regardless of the number of onsets. Eye-scan strategies were also disrupted by the appearance of the onset distractors, although the proportion of trials on which the eyes were directed to the onsets was the same regardless of the number of onsets. In Experiment 2, we manipulated the time of presentation of two taskirrelevant onsets in order to further examine whether multiple onsets would be attended and fixated prior to attending a color singleton target. Again, subjects made a saccade to a task-irrelevant onset on a substantial proportion of trials prior to fixating the target. However, saccades to the second onset were rare. Experiment 3 served as a replication of Experiment 1 but without the requirement for subjects to move their eyes to detect and identify the singleton target. The RT results were consistent with those in Experiment 1; dual onsets had no larger an effect on response speed than single onset distractors. These data are discussed in terms of the interaction between top-down and bottom-up control of attention and the eyes.     

DECREASING CHILDREN'S RISK TAKING ON THE PLAYGROUND

Playground mishaps are some of the most common sources of injury and are the leading killer of children. The present study used a multiple baseline design across three classrooms (N = 379 children). With minimal teaching and rewards, children decreased and maintained decreased risky playground behaviors on slides. Floor effects on climbers prevented the demonstration of similar effects. The decreases seen in risky slide behavior are discussed within the context of preventive safety training for playground injuries.     

Parent–child talk and children's memory for stressful events

The relationship between parents' styles of talking about past events with their children and children's recall of stressful events was explored. In this investigation, 2‐ to 5‐year‐old children's recall of injuries requiring hospital emergency room treatment was assessed within a few days of the injury and again 2 years later, along with the way their parents reminisced with them about the event. Correlational analyses showed that age and parental reminiscing style were consistently related to child memory; regression analyses showed that although age was most important, parents who were more elaborative had children who recalled more during their initial interview about the harder‐to‐remember hospital event. Thus, an elaborative parental style may help children's recall of even highly salient and stressful events. Copyright © 2006 John Wiley & Sons, Ltd.     

Prefrontal cognitive ability, intelligence, Big Five personality, and the prediction of advanced academic and workplace performance

Studies 1 and 2 assessed performance on a battery of dorsolateral prefrontal cognitive ability (D-PFCA) tests, personality, psychometric intelligence, and academic performance (AP) in 2 undergraduate samples. In Studies 1 and 2, AP was correlated with D-PFCA (r=.37, p<.01, and r=.33, p<.01, respectively), IQ (r=.24, p<.05, and r=.38, p<.01, respectively), and Conscientiousness (r=.26, p<.05, and r=.37, p<.01, respectively). D-PFCA remained significant in regression analyses controlling for intelligence (or g) and personality. Studies 3 and 4 assessed D-PFCA, personality, and workplace performance among (a) managerial-administrative workers and (b) factory floor workers at a manufacturing company. Prefrontal cognitive ability correlated with supervisor ratings of manager performance at values of r ranging from .42 to .57 (ps<.001), depending on experience, and with factory floor performance at pr=.21 (p=.02), after controlling for experience, age, and education. Conscientiousness correlated with factory floor performance at r=.23.