Lateralized Changes in Regional Cerebral Blood Flow during Performance of Verbal and Facial Recognition Tasks: Correlations with Performance and “Effort”

Functional neuroimaging has been used to investigate neural substrates of mnemonic processes, and cerebral blood flow (CBF) measures have been sensitive to activation with memory tasks. Studies of memory with two-dimensional¹³³Xenon clearance techniques found that word and face recognition tasks produced contralateral CBF changes in mid-temporal cortical regions. This study replicated the activation paradigm, expanding to the three-dimensional resolution of positron emission tomography (PET). Word and face recognition, and a control baseline task were administered to 19 healthy right-handed volunteers (11 men, 8 women) during successive 10 min PET¹⁵O-water measures of CBF. Quantitative CBF rates were calculated with the arterial input function and the equilibrium model. Redistributions of blood flow were compared across tasks using both absolute and relative (region/whole brain) CBF.Replicating the¹³³Xenon clearance findings, CBF was “appropriately” lateralized during task performance (left–right for words > left–right for faces) in the mid-temporal region. Contrary to predictions, the recognition tasks did not activate expected mesolimbic or prefrontal areas. The task-induced CBF changes also correlated with performance. Bilateral CBF in mid-temporal and parahippocampal gyrus regions of interest correlated with the ability to correctly identify word targets (sensitivity). Left-lateralized CBF in the amygdala and hippocampus correlated with better word sensitivity as well as specificity (ability to correctly reject foils). Complementally, right-lateralized CBF in the parahippocampal gyrus correlated with better face specificity performance. In addition, left-lateralized CBF in the amygdala and right-lateralized CBF in the parahippocampal gyrus and hippocampus correlated with “mental effort” indices (task performance relative to basal ability) for word and face memory tasks, respectively. Thus, whereas this recognition task showed the expected lateralized increase in the mid-temporal region and not in frontal and limbic areas, lateralized activation in some of these areas was associated with better performance. Exploratory analyses on other regions showed lateralized changes in one additional temporal region, the occipital-temporal, and several limbic regions.     

A theological escape from the Cartesian Circle?

International Journal for Philosophy of Religion -     

One-session cognitive treatment of dental phobia: preparing dental phobics for treatment by restructuring negative cognitions

The purpose of this study was to investigate the effectiveness of a single session of cognitive restructuring in a sample of phobic dental patients. Fifty-two patients were randomly assigned to one of three conditions: cognitive restructuring (modification of negative cognitions), provision of information (about oral health and dental treatment), and a waiting list control condition. Both interventions maximally lasted one hour. In comparison with the waiting list control condition and the information intervention condition, the cognitive intervention condition not only showed a large decrease in frequency and believability of negative cognitions, but also exhibited a clear decline in dental trait anxiety. Analysis at a follow-up of one year demonstrated a further, drastic reduction in dental anxiety in both intervention conditions, wherein the difference among these conditions was not maintained. It is concluded that it is possible to obtain substantial reductions of dental trait anxiety through a single session of cognitive restructuring. Nevertheless, repeated exposure to the dental situation seems necessary for a further reduction of anxiety.     

Behavioral Intentions: Which Ones Predict Fertility Behavior in Married Couples?1

The published literature on the relationship between behavioral intentions and fertility behavior exhibits four major problems: inconsistent and confusing use of theoretical constructs, limited use of different types of intentions, use of nonbehavioral outcomes, and failure to explore adequately the couple aspects of the intentions/behavior relationship. The study reported here addresses these problems by using a theoretical framework that characterizes the psychological/behavioral sequence leading to a planned conception, three different types of fertility intentions, a behavioral outcome variable, and data from 196 married couples with no children and 185 married couples with one child. Data analysis results in a simultaneous equation, constrained regression model which indicates that child-timing intentions are the most important predictors of proceptive behavior over a 3-1/2 year period and that childbearing intentions are next in importance; that behavioral intentions are the final common pathway through which fertility motivations, attitudes, beliefs, and desires affect behavior; that the use of proceptive behavior as an outcome variable improves the explanatory power of our models; and that the interaction of couple intentions do not demonstrate greater husband or wife influence over couple proceptive behavior but do demonstrate that disagreement has a delaying effect on the onset of that behavior.     

Pronominalization and discourse coherence,discourse structure and pronoun interpretation

Two self-paced reading-time experiments are reported that examine the time course of pronoun interpretation processes based on local discourse structure and on world knowledge. The characterization of local discourse structure is based on recent work on centering, which provides a specific formulation of how the ways in which sentences make reference to common entities determines the coherence of discourse segments and how discourse structure influences interpretation of ambiguous pronouns. The results of the first experiment show that readers generate a default interpretation of a pronoun based on features of local discourse structure, and that that default interpretation is later confirmed or overridden by knowledge-based processes. The results of the second experiment show that local discourse structure continues to influence pronoun interpretation even when the semantic information that ultimately compels interpretation occurs before the pronoun. These results support the view that processes acting on local discourse structure play a powerful role in guiding language comprehension.     

Is space-time discrete or continuous? — An empirical question

In this paper I present the Discrete Space-Time Thesis, in a way which enables me to defend it against various well-known objections, and which extends to the discrete versions of Special and General Relativity with only minor difficulties. The point of this presentation is not to convince readers that space-time really is discrete but rather to convince them that we do not yet know whether or not it is. Having argued that it is an open question whether or not space-time is discrete, I then turn to some possible empirical evidence, which we do not yet have. This evidence is based on some slight differences between commonly occurring differential equations and their discrete analogs.I would like to express my thanks to John McKie with whom I have had several inspiring conversations about discrete space. I would also like to thank the audience of a paper on this topic which I read in October 1991 at the College Park campus of the University of Maryland. Finally I would like to thank the referees ofSynthese for their comments. One of them, in particular, should be thanked especially for help in improving Appendix Two.     

The third person effect: Social distance and perceived media bias

Two studies were conducted to determine the conditions under which the third person effect (Davison, 1983) operates. It was hypothesized that the effect would be accentuated as target groups of others became more remote from the self. A second objective was to determine whether the effect operates in the absence of overtly persuasive intent in the media. Television programmes concerned with moral themes were employed as stimuli. The results further support Davison's claim that overestimation of media effects is greater when people imagine the responses of others whom they do not know than those of familar individuals. The results also indicate that the third person effect does operate in the absence of perceived persuasive intent, but is accentuated when bias is perceived by viewers.     

GRW and the tails problem

The GRW theory is a recent attempt to solve the measurement problem in quantum mechanics, and the tails problem is a well-known and potentially fatal criticism of the GRW theory. The first half of the paper is an exposition of the measurement problem, the GRW theory, and the tails problem. In the remainder of the paper, two methods of dealing with the tails problem are considered: first, altering the GRW theory so as to avoid the tails problem; and second, denying that the tails problem is more than a novel aspect of a universal vagueness in the way scientific theories relate to everyday language.