Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors

In rats, pretraining ip administration of the central benzodiazepine receptor antagonist, flumazenil (5.0 mg/kg), or of the inverse agonist, n-butyl-beta-carboline-3-carboxylate (BCCB) (0.2 or 0.5 mg/kg), facilitated retention of a step-down inhibitory avoidance task; the central agonists, clonazepam and diazepam (0.4 or 1.0 mg/kg), had an opposite effect, and the peripheral agonist, 4'-chlordiazepam (1.25 or 6.25 mg/kg), was without effect. Pre- but not post-training flumazenil (2.0 mg/kg) blocked the effect of BCCB (0.5 mg/kg), clonazepam (1.0 mg/kg), or diazepam (1.0 mg/kg) given also pretraining. The post-training administration of all of these drugs had no effect on retention of the avoidance task. Flumazenil (5.0 mg/kg) and BCCB (0.5 mg/kg), given before training, enhanced retention test performance of habituation to a buzzer but not of habituation to an open field. In the three tasks studied, none of the drugs used had any appreciable effect on training session parameters. These results suggest that there is an endogenous mechanism mediated by benzodiazepine agonists, sensitive to inverse agonists, that normally down-regulates acquisition of certain behaviors; this mechanism becomes activated only when the tasks involve or occur with a certain degree of stress or anxiety (i.e., inhibitory avoidance or habituation to the buzzer) and not in less stressful or anxiogenic tasks (i.e., habituation to an open field).     

A simple method using a single video camera to determine the three-dimensional position of a fish

In the present paper, we describe a method for recording the coordinates of a fish in an aquarium in a three-dimensional space, using a single video camera and a mirror. We use photogrammetic equations for this, considering the image obtained in the mirror as a virtual image obtained by a second camera. A transformation of the coordinate system is required to express the obtained coordinates in anx,y,z system defined by the edges of the aquarium. The accuracy of the proposed method was estimated, and errors in extreme conditions were found to be 0.8% to 1.2 %, compared with the dimensions of the aquarium used in the test.     

Gender Attitudes and Public Opinion Towards Electoral Gender Quotas in Brazil

Research on public opinion towards affirmative action shows that citizens often support the principle of equality while simultaneously rejecting policies that promote it in a pattern described as the “principle-policy puzzle.” The scholarship also shows that ideology and prejudice towards the targeted group explain the puzzle with respect to racial affirmative action. In this article, we use unique survey questions included in the 2014 round of the AmericasBarometer in Brazil to show that citizens tend to support electoral gender quotas while rejecting gender-based egalitarianism in a reversed version of the “principle-policy puzzle.” We argue that a different type of gender attitudes, namely benevolent sexism, shapes support for gender quotas as well as for the principle of equality. While benevolent sexists tend to reject gender equality based on views about gender complementarity and stereotypes about women's purity, they also support quotas as policies to foster such values. Our findings suggest that even though the political and scholarly debates can provide sound normative reasons for the adoption of quotas across different contexts, public support for them often relies on paternalistic views and expectations about the role of women in politics.     

Distinct ventral and dorsal hippocampus AP5 anxiolytic effects revealed in the elevated plus-maze task in rats

The hippocampal formation (HPC) mediates processes associated with learning, memory, anxiety and fear. The glutamate N-methyl-d-aspartate (NMDA)-receptor subtype is involved in many HPC functional processes related to learning and memory. Although not tested for the HPC, NMDA-receptor antagonists reduced fear and anxiety related responses when applied to other brain regions mediating defensive behaviour. Consequently, this study evaluated the effects of ventral or dorsal HPC application of the NMDA-receptor antagonist, AP5, in rats submitted to the Trial 1/Trial 2 elevated plus-maze (EPM) task. Ventral, but not dorsal, infusions of AP5 (6 and 24 nmol) before EPM Trial 1 increased open arms exploration and reduced risk assessment behavior, suggesting an anxiolytic-like effect. Furthermore, no interference in the avoidance responses was detected during EPM Trial 2 after AP5 infusion into the ventral or dorsal HPC before Trial 1, post-trial 1, or before Trial 2. These data support the notion of differential involvement of ventral HPC, but not dorsal, in mechanisms associated with anxiety and suggest the participation of the glutamatergic transmission, through NMDA receptor, into the ventral HPC in the mediation of defensive behavior.     

In the name of democracy: The value of democracy explains leniency towards wrongdoings as a function of group political organization

According to the “democracy‐as‐value” hypothesis, democracy has become an ideological belief system providing social value to democratic individuals, groups and institutions, granting legitimacy to their actions (even if dishonest or violent), and protecting them from consecutive punishments. The present research investigates the extent to which this legitimizing process is based on the individual endorsement of democratic principles. Across four experiments, following the misdeed of a (few) group member(s), respondents who valued democratic group organization and democracy in general expressed more lenient retributive justice judgments towards democratic (as compared with nondemocratic) offender groups. These findings shed light on the ways in which democratic ideology infuses justice judgments. Copyright © 2015 John Wiley & Sons, Ltd.     

Methodological naturalism and epistemic internalism

Epistemic naturalism holds that the results or methodologies from the cognitive sciences are relevant to epistemology, and some have maintained that scientific methods are more compatible with externalist theories of justification than with internalist theories. But practically all discussions about naturalized epistemology are framed exclusively in terms of cognitive psychology, which is only one of the cognitive sciences. The question addressed in this essay is whether a commitment to naturalism really does favor externalism over internalism, and we offer reasons for thinking that naturalism in epistemology is compatible with both internalist and externalist conceptions of justification. We also argue that there are some distinctively internalist aims that are currently being studied scientifically and these notions, and others, should be studied by scientific methods. This essay is dedicated to Deborah Mayo, who has long advocated using error statistical techniques to analyze and resolve epistemological puzzles in the philosophy of science. This essay follows the same spirit by advocating that computational concepts and techniques be applied within the heart of traditional, analytic epistemology.     

Psychological morbidity, illness representations, and quality of life in female and male patients with obstructive sleep apnea syndrome

Obstructive sleep apnea syndrome (OSAS) is a sleep-related breathing disorder that affects both women and men. The aim of this study was to characterize and investigate the differences in terms of anxiety, depression, illness perception, and quality of life between female and male OSAS patients from a total of 111 patients (33 women and 78 men) who were recently diagnosed with OSAS in an outpatient clinic of a University Hospital in Portugal. They underwent a standardized protocol that included evaluation to assess of psychological morbidity (anxiety and depression - Hospital Anxiety and Depression Scale), illness representations (Brief Illness Perception Questionnaire), and quality of life (Sleep Apnea Quality of Life Index). The most significant differences between female and male OSAS patients result of apnea/hypopnea index (AHI), after controlling for body mass index (p?相似文献