Impaired frontostriatal cognitive functioning following posteroventral pallidotomy in advanced Parkinson's disease

We investigated the long-term effects of posteroventral pallidotomy on tests sensitive to the functional integrity of frontostriatal neural systems in a sample of 11 patients with advanced Parkinson's disease (PD). Patients were assessed within 1 month prior to surgery and at 12 months following pallidotomy. Changes in outcome measures were compared to a control sample of equally performing PD patients receiving nonsurgical medical management assessed over a 12-month period. Measures of cognitive abilities sensitive to frontostriatal functional integrity tested psychomotor processing speed, executive components of working memory, and reasoning. Additional tests of general mental status and semantic memory ability were utilized to assess the specificity of the effect of pallidotomy on cognitive function. Significant declines in performance on all measures sensitive to frontostriatal integrity were found for the surgery group but not the PD control group. No significant changes in performance were found on the measures of general mental status or semantic memory for either the surgery or PD control samples. These results suggest that the posteroventral pallidotomy selectively impairs performance on tests of frontostriatal cognitive abilities.     

Memory,emotional processing,and anxiety: A critique

This article explores evidence for an emotional processing view of the role of memory in anxiety disorders. It is argued that Lang (1977) and Foa and Kozak’s (1985) emotional processing hypothesis is adequate to account for mechanisms involved in most anxiety syndromes, but is less suitable for explaining persistent fear behavior in Panic Disorder and Generalized Anxiety Disorder. An alternative explanation for these disorders is provided.     

Ethnic differences in subclinical paranoia: an expansion of norms of the paranoia scale

The Paranoia Scale (PS) was designed to assess subclinical paranoid ideation (A. Fenigstein & P. A. Vanable, 1992). Despite its established validity, the PS has several problems that need to be addressed. There are no normative data on ethnic minority groups such as African Americans, making it difficult to interpret this group's performance on the PS. Data from the present research revealed that African Americans scored higher on the PS than non-Hispanic Whites. However, interpretation of these findings should be tempered as they may reflect other contextual factors such as discrimination and the impact of racism. Implications for using the PS with African Americans and possible explanations for the observed results were discussed.     

Qualitatively distinct factors contribute to elevated rates of paranoia in autism and schizophrenia

A converging body of clinical and empirical reports indicates that autism features elevated rates of paranoia comparable to those of individuals with paranoid schizophrenia. However, the distinct developmental courses and symptom manifestations of these two disorders suggest that the nature of paranoid ideation may differ between them in important and meaningful ways. To evaluate this hypothesis, we compared patterns of responses on the Paranoia Scale between actively paranoid individuals with schizophrenia (SCZP), individuals with schizophrenia who were not actively paranoid (SCZNP), adults with an Autism Spectrum Disorder (ASD), and healthy controls. Despite an overall similar level of heightened paranoia in the ASD and SCZP groups, discriminant correspondence analysis (DiCA) revealed that these groups were characterized by unique underlying factors. Paranoia in the SCZP group was defined by a factor based upon victimization, suspicion, and threat of harm. Whereas paranoia in the ASD group was partially characterized by this factor, it was distinguished from SCZP by an additional pattern of responses reflective of increased social cynicism. These findings indicate that paranoia in ASD is supported by qualitative factors distinct from schizophrenia and highlight mechanistic differences in the formation of paranoid ideation that may inform the development of disorder-specific treatments. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

So, are we the massively lucky species?

We are in vehement agreement with most of Vaesen's key claims. But Vaesen fails to consider or rebut the possibility that there are deep causal dependencies among the various cognitive traits he identifies as uniquely human. We argue that "higher-order relational reasoning" is one such linchpin trait in the evolution of human tool use, social intelligence, language, and culture.     

Neurobiological Correlates of Autism: A Review of Recent Research

This review paper integrates recent structural and functional imaging, postmortem, animal lesion, and neurochemical research about the pathophysiology of autism. An understanding of the neurobiological correlates of autism is becoming increasingly important as more children are diagnosed with the condition and funding for well-targeted interventions increases. Converging evidence suggests that autism involves abnormalities in brain volume, neurotransmitter systems, and neuronal growth. In addition, evidence firmly links autism with abnormalities in the cerebellum, the medial temporal lobe, and the frontal lobe. Potential implications of these findings and suggestions for future research are reviewed.     

Indicators of quality teaching in intensive behavioral intervention: a survey of parents and professionals

Intensive Behavioral Intervention (IBI) is being used extensively with children with autism. It is widely accepted that a large quantity of IBI is necessary to maximize children's outcomes, but outcomes remain variable and one reason for this is likely related to the quality of intervention children are receiving. There is little empirical evidence regarding the nature and measurement of quality IBI. This paper presents results of a survey examining the views of parents and professionals about quality IBI and how it should be measured. Parents rated the importance of 11 IBI characteristics and professionals indicated whether these characteristics should be measured objectively or subjectively. All respondents selected three characteristics they thought most important and answered open‐ended questions about: additional quality indicators and IBI programming issues for which empirical evidence is needed. Parental ratings supported the importance of virtually all the suggested characteristics. Professional results emphasized the importance of objective measurement. The most frequently selected indicators of high quality teaching across groups were: creating generalization opportunities, administering reinforcers of the appropriate type, and using effective/appropriate behavior management strategies. There were interesting differences across groups and many valuable suggestions about additional indicators of quality and empirical questions of interest. Copyright © 2006 John Wiley & Sons, Ltd.     

Darwin's mistake: explaining the discontinuity between human and nonhuman minds

Over the last quarter century, the dominant tendency in comparative cognitive psychology has been to emphasize the similarities between human and nonhuman minds and to downplay the differences as "one of degree and not of kind" (Darwin 1871). In the present target article, we argue that Darwin was mistaken: the profound biological continuity between human and nonhuman animals masks an equally profound discontinuity between human and nonhuman minds. To wit, there is a significant discontinuity in the degree to which human and nonhuman animals are able to approximate the higher-order, systematic, relational capabilities of a physical symbol system (PSS) (Newell 1980). We show that this symbolic-relational discontinuity pervades nearly every domain of cognition and runs much deeper than even the spectacular scaffolding provided by language or culture alone can explain. We propose a representational-level specification as to where human and nonhuman animals' abilities to approximate a PSS are similar and where they differ. We conclude by suggesting that recent symbolic-connectionist models of cognition shed new light on the mechanisms that underlie the gap between human and nonhuman minds.     

Lessons from social psychology on discrediting psychiatric stigma.

Advocacy, government, and public-service groups rely on a variety of strategies to diminish the impact of stigma on persons with severe mental illness. These strategies include protest, education, and promoting contact between the general public and persons with these disorders. The authors argue that social psychological research on ethnic minority and other group stereotypes should be considered when implementing these strategies. Such research indicates that (a) attempts to suppress stereotypes through protest can result in a rebound effect; (b) education programs may be limited because many stereotypes are resilient to change; and (c) contact is enhanced by a variety of factors, including equal status, cooperative interaction, and institutional support. Future directions for research and practice to reduce stigma toward persons with severe mental illness are discussed.