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161.
162.
Fei Geng Jia Tian Jian-Lin Wu Yun Luo Wen-Jun Zou Chao Peng Gui-Feng Lu 《Cognitive, affective & behavioral neuroscience》2018,18(1):58-67
The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABAA receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders. 相似文献
163.
探索性因素分析决定因子抽取的方法主要有Bartlett法、K1原则、碎石检验法、Aaker原则、PA、MAP等六种,通过对样本1的395名大学生的学习过程问卷调查获得真实数据,运用这六种方法进行因素分析分别抽取7、4、2、4、3、2个因子;应用样本2的383名大学生的问卷调查数据进行验证性因素分析,结果显示,碎石检验方法与MAP方法抽取的二因素模型更理想。研究表明,因子抽取需兼顾“简约性原则”与“完备性原则”,同时要根据一定的理论建构、专业知识和经验来决定因子数。 相似文献
164.
该研究以城市移民子女作为研究对象,主要探讨社会支持对城市移民子女生活满意度的影响及预测作用,以及学校适应在社会支持与生活满意度之间的作用机制。研究结果表明:1)社会支持、学校适应与城市移民子女的生活满意度均呈显著相关,社会支持对城市移民子女生活满意度具有显著的正向预测作用。2)学校适应在社会支持影响城市移民子女生活满意度中起部分中介作用,即社会支持可以直接影响生活满意度,也可以通过学校适应间接影响生活满意度。但社会支持对生活满意度的直接影响是最主要的影响路径。. 相似文献
165.
We tested how anticipated emotions interact with personal experience in risk behavior to improve predictions from TPB on behavioral intention (BI) and behavioral expectation (BE) for sex without condom (Study 1) and excessive drinking (Study 2). In the moderate-high experience group, anticipated emotional profiles (AEPs) improve TPB prediction from 28% to 45% in the case of BI and from 19% to 40% in that of BE in relation to sexual risk behavior (Study 1), and from 23% to 36% in the case of BI and from 17% to 31% in that of BE in relation to binge drinking (Study 2). However, in the low-experience group (Study 2) AEPs improve TPB predictions for BI (12% to 34%) but not for BE, showing that in less experienced people BI and BE are not equivalent: anticipated emotions have different relevance in their prediction. These results were replicated using a general negative anticipated emotion index (averaging emotional categories). 相似文献
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Online game addiction is a new mental disorder. This disorder is difficult to describe because of its comprehensive nature. Many online game players have problems controlling their playing time. They cannot stop playing a game that they enjoy. This research surveyed the past literature on "flow" and time disorder theory. A time distortion experiment was conducted. This research invited 64 children, teenagers, and young adults to investigate player skill and playing time effects on online game break-off. The playing experience and degree of time distortion were measured and analyzed. The results showed that both novice and expert online game players were subject to time distortion. The participants had difficulty breaking off from the game without intrusion by others in the real world. This research also suggests eight questions for self-evaluation for online game addiction. 相似文献
169.
Two studies were conducted in which human participants rated pairs of words according to the perceived degree to which the
words’ referents shared semantic features. The participants found the task intuitive, simple, and quick to complete. The ratings
were reliable and valid. Interrater and interstudy correlations were high, and ratings were good predictors of known feature
overlap values obtained from existing semantic feature norms. 相似文献
170.
The Stroop paradigm was used to examine the role of phonological activation in semantic access and its development in reading Chinese characters. Subjects (age 7-23 years) of different reading ability were asked to name the display color of Chinese characters. The characters were displayed in four different colors: red, yellow, blue and green. There were five types of relationships between a character and its display color: semantically congruent, phonologically congruent, semantically incongruent, phonologically incongruent and neutral. In addition to the classical Stroop effects, interference and facilitation effects from the homophones of color characters were also observed. The younger children and those with lower reading ability exhibited stronger Stroop effects. These findings suggest that phonological codes are activated automatically in Chinese character recognition. Furthermore, there is more phonological activation in the semantic retrieval of children in lower grades and those with lower reading ability. 相似文献