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541.
542.
Hu D Cao P Thiels E Chu CT Wu GY Oury TD Klann E 《Neurobiology of learning and memory》2007,87(3):372-384
Superoxide has been shown to be critically involved in several pathological manifestations of aging animals. In contrast, superoxide also can act as a signaling molecule to modulate signal transduction cascades required for hippocampal synaptic plasticity. Mitochondrial superoxide dismutase (SOD-2 or Mn-SOD) is a key antioxidant enzyme that scavenges superoxide. Thus, SOD-2 may not only prevent aging-related oxidative stress, but may also regulate redox signaling in young animals. We used transgenic mice overexpressing SOD-2 to study the role of mitochondrial superoxide in aging, synaptic plasticity, and memory-associated behavior. We found that overexpression of SOD-2 had no obvious effect on synaptic plasticity and memory formation in young mice, and could not rescue the age-related impairments in either synaptic plasticity or memory in old mice. However, SOD-2 overexpression did decrease mitochondrial superoxide in hippocampal neurons, and extended the lifespan of the mice. These findings increase our knowledge of the role of mitochondrial superoxide in physiological and pathological processes in the brain. 相似文献
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与西方心理学以科学主义为主体的“由下至上”的研究思路不同,中国传统心理学探究走的是“由上至下”的研究路线,即从心理及精神层面最高端入手,强调心理的道德与理性层面,故其实质是人文主义的。现代新儒学作为人文主义心理学研究典范,具有心理学研究“另一种声音”的独特价值与意义。现代新儒学研究背景及思路的展开,呈现出以传统心理学思想为深厚根基的中国近代心理学的独特个性与自信。这是现代新儒学对中国心理学的最大贡献 相似文献
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This article addresses the nature and measurement of White racial identity. White identification is conceptualized as an automatic association between the self and the White ingroup; this association is fostered through social exposure to non-Whites and serves to link self- and ingroup evaluations. Four studies validated a measure of White identification against criteria derived from this model. In Study 1, the White Identity Centrality Implicit Association Test (WICIAT) predicted response latencies in a task gauging self-ingroup merging. In Study 2, the WICIAT correlated with census data tapping exposure to non-Whites. In Studies 3 and 4, the WICIAT predicted phenomena associated with the linking of self- and ingroup evaluations: identity-related biases in intergroup categorization (Study 3) and self-evaluative emotional reactions to ingroup transgressions (Study 4). Together, the findings shed light on the antecedents and consequences of White identity, an often-neglected individual difference construct. 相似文献
548.
The heterogeneity of grain-orientation-dependent residual stress (ODRS) in polycrystalline materials has received a great deal of attention in the past few years. This letter describes a novel method, called the spherical harmonics approach (SHA), for analysing ODRS. The stress orientation distribution function (SODF) is defined to describe quantitatively the mean field of the residual stress as a function of grain orientation in the Euler space. This stress field can be expanded in terms of generalized spherical harmonics, and its series coefficients can be determined directly from lattice strain maps (strain pole figures). While solving the deconvolution problem of this stress field, the stress or strain equilibrium between neighbouring grains is considered simultaneously by implementing a self-consistent model in the iterative algorithm. The application of the SHA is illustrated by the construction of the SODF for a cold-rolled and annealed austenite stainless steel, using strain pole figures obtained by neutron diffraction. 相似文献
549.
H. Wei J.J. Liang P. Peng Q. Zheng X.F. Sun B.Z. Sun 《Philosophical Magazine Letters》2013,93(5):299-311
The valence band structures of the NiAl–Mo alloy was investigated by photoelectron spectroscopy. The valence band spectra of the NiAl–Mo alloy was shifted away from the Fermi level so that the Ni-d-band centroid moved to a higher energy by 0.22 eV as Mo was added. A possible explanation lied in the overlap of Ni-d bands in the energy with Mo-d and Al-p bands. The participation of Mo-d bands was correlated with the site preference of Mo in NiAl alloys. 相似文献
550.
Yue Qi Fen Wu Xiaofeng Peng Ralph E. Steuer 《Journal of Multi-Criteria Decision Analysis》2013,20(3-4):127-139
In this paper, we study corporate social responsibility (CSR) in China through the prism of investments. We work with large stocks and assess their CSR performance from agency CSR data. We formulate Chinese CSR by a multiple objective extension of a traditional portfolio selection model and analytically solve the extension. We also solve the extension by a genetic algorithm and directly evaluate the algorithm's performance against the analytical solution. The multiple objective formulation is tested by randomly choosing nondominated portfolios with out‐of‐sample data to identify nondominated portfolios that outperform the 1/n portfolio (equally weighted portfolio). Copyright © 2013 John Wiley & Sons, Ltd. 相似文献