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Fei Geng Jia Tian Jian-Lin Wu Yun Luo Wen-Jun Zou Chao Peng Gui-Feng Lu 《Cognitive, affective & behavioral neuroscience》2018,18(1):58-67
The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABAA receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders. 相似文献
133.
该研究以城市移民子女作为研究对象,主要探讨社会支持对城市移民子女生活满意度的影响及预测作用,以及学校适应在社会支持与生活满意度之间的作用机制。研究结果表明:1)社会支持、学校适应与城市移民子女的生活满意度均呈显著相关,社会支持对城市移民子女生活满意度具有显著的正向预测作用。2)学校适应在社会支持影响城市移民子女生活满意度中起部分中介作用,即社会支持可以直接影响生活满意度,也可以通过学校适应间接影响生活满意度。但社会支持对生活满意度的直接影响是最主要的影响路径。. 相似文献
134.
本文通过对桑德尔政治哲学思想的梳理和分析得出,桑德尔的政治哲学立场并非像国内学者普遍所界定的"共同体主义",而是共和主义.在做此界定之后,本文着力于分析共同体主义的理论缺陷以及桑德尔排斥"共同体主义"标签而发展共和主义的理由所在;最后本文指出,桑德尔所坚持的现代共和主义本身亦有着诸多尴尬之处. 相似文献
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Online game addiction is a new mental disorder. This disorder is difficult to describe because of its comprehensive nature. Many online game players have problems controlling their playing time. They cannot stop playing a game that they enjoy. This research surveyed the past literature on "flow" and time disorder theory. A time distortion experiment was conducted. This research invited 64 children, teenagers, and young adults to investigate player skill and playing time effects on online game break-off. The playing experience and degree of time distortion were measured and analyzed. The results showed that both novice and expert online game players were subject to time distortion. The participants had difficulty breaking off from the game without intrusion by others in the real world. This research also suggests eight questions for self-evaluation for online game addiction. 相似文献
138.
The Stroop paradigm was used to examine the role of phonological activation in semantic access and its development in reading Chinese characters. Subjects (age 7-23 years) of different reading ability were asked to name the display color of Chinese characters. The characters were displayed in four different colors: red, yellow, blue and green. There were five types of relationships between a character and its display color: semantically congruent, phonologically congruent, semantically incongruent, phonologically incongruent and neutral. In addition to the classical Stroop effects, interference and facilitation effects from the homophones of color characters were also observed. The younger children and those with lower reading ability exhibited stronger Stroop effects. These findings suggest that phonological codes are activated automatically in Chinese character recognition. Furthermore, there is more phonological activation in the semantic retrieval of children in lower grades and those with lower reading ability. 相似文献
139.
本研究包括三个实验。实验一在混和呈现条件下比较被试对隐喻句和类属句的加工时问,发现可理解性高的隐喻句的R_T不比类属句的慢。实验二在分组呈现条件下比较被试加工隐喻句与类属句的速度,结果与实验一基本相同。实验一、二中还发现类属概念的层次与语义加工时间没有必然联系。实验三比较了隐喻句对三类概念的启动作用,发现隐喻对自身的语义特征概念有明显的启动作用。根据三个实验的结果,我们提出了一种称为特征联结的语义网络结构模型。 相似文献
140.
行动经济理论认为个体对物理环境的感知与其具备的资源有关,而焦虑与资源不足有关。基于此,本研究通过3个实验来探讨3种不同性质的焦虑对重量感知判断的影响。实验1通过身体姿势诱发焦虑,结果发现同放松的身体姿势相比,焦虑的身体姿势能诱发出焦虑且此姿势下个体会认为背包的重量更重。实验2通过具有压力性的外部任务诱发焦虑,结果显示同奇偶判断任务相比,心算任务能诱发出明显的焦虑且此任务下个体将背包的重量判断为更重。实验3探讨特质焦虑的影响,结果发现高特质焦虑个体同低特质焦虑者相比会认为背包的重量更重。本研究表明焦虑会影响个体对物体物理属性的感知。 相似文献