Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients

Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely examined in fMRI studies investigating the underlying neural mechanisms in aphasia recovery. The purpose of this study was to acquire fMRI test-retest data examining semantic decisions both within and between two aphasia patients. Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no button-box semantic judgments of iconic sentences presented in the Computer-assisted Visual Communication (C-ViC) program. We investigated the critical issue of intra-subject reliability by exploring similarities and differences in regions of activation during participants' performance of identical tasks twice on the same day. Each participant demonstrated high intra-subject reliability, with response decrements typical of task familiarity. Differences between participants included greater left hemisphere perilesional activation in the individual with better response to C-ViC training. This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery.     

Smoking withdrawal dynamics: II. Improved tests of withdrawal-relapse relations

In this article, the authors assessed whether continuously scaled symptom parameters derived from growth models (T. M. Piasecki et al., 2003) are linked to smoking at long-term follow-up by using data from a large-scale clinical trial (N = 893). Results revealed that higher withdrawal intercepts, positive linear slopes, and greater volatility were all positively associated with relapse, and cigarette coefficients (indicating smoking-induced withdrawal reduction) were negatively related to relapse. In models keyed around the first lapse to smoking, those destined to lapse reported more severe withdrawal during abstinence, and withdrawal patterns discriminated groups defined according to lapse duration. The findings complement earlier heterogeneity studies in implicating the pattern of changing withdrawal symptoms over time as a factor strongly associated with smoking relapse.     

Demographic characteristics,social competence,and behavior problems in children with gender identity disorder: a cross-national,cross-clinic comparative analysis

This study examined demographic characteristics, social competence, and behavior problems in clinic-referred children with gender identity problems in Toronto, Canada (N = 358), and Utrecht, The Netherlands (N = 130). The Toronto sample was, on average, about a year younger than the Utrecht sample at referral, had a higher percentage of boys, had a higher mean IQ, and was less likely to be living with both parents. On the Child Behavior Checklist (CBCL), both groups showed, on average, clinical range scores in both social competence and behavior problems. A CBCL-derived measure of poor peer relations showed that boys in both clinics had worse ratings than did the girls. A multiple regression analysis showed that poor peer relations were the strongest predictor of behavior problems in both samples. This study—the first cross-national, cross-clinic comparative analysis of children with gender identity disorder—found far more similarities than differences in both social competence and behavior problems. The most salient demographic difference was age at referral. Cross-national differences in factors that might influence referral patterns are discussed.     

Group identification moderates emotional responses to perceived prejudice

Two studies tested the prediction that group identification (importance of the group in the self-concept) moderates the impact of perceived discrimination on self-evaluative emotions (depression and self-esteem). In Study 1, women low in gender identification experienced less depressed emotion and higher self-esteem if a negative evaluation was due to sexism than when it was not. The self-evaluative emotions of women high in gender identification were not buffered by attributions to sexism. In Study 2, ethnic identification and depressed emotions were positively related when Latino-Americans read about pervasive prejudice against the ingroup but were negatively related when they read about prejudice against an outgroup. Both studies demonstrated that for highly group identified individuals, prejudice against the ingroup is a threat against the self. Thus, the self-protective strategy of attributing negative feedback to discrimination may be primarily effective for individuals who do not consider the group a central aspect of self.     

It's not my fault: when and why attributions to prejudice protect self-esteem

This study tested the hypothesis that awareness of the possibility of being a target of discrimination can provide individuals with a means of self-esteem protection when they are faced with negative outcomes. Men and women contemplated being rejected from a course due to sexism, personal deservingness, or an exclusively external cause. Regardless of gender, participants in the sexism condition blamed themselves less, attributed the rejection less to internal causes, and anticipated feeling less depressed than those in the personal deservingness condition. Furthermore, the more participants discounted the rejection--blamed it more on discrimination than themselves--the less depressed emotions they anticipated feeling. Discounting did not buffer participants from feeling hostility or anxiety. These findings advance our understanding of when and why attributions to prejudice protect emotional well-being.     

Strain and gender specific effects in the forced swim test: effects of previous stress exposure

The chronic mild stress (CMS) procedure was developed in rodents to target anhedonia, the core symptom of depressive melancholia. Stress exposure has been shown to induce a variety of physiological, biochemical and behavioral alterations associated with depression, although its anhedonic consequences as indexed by either sucrose intake and preference or thresholds for brain stimulation reward are less reliably observed. In the present study, we assessed the effects of six weeks of CMS on the latter measure in two strains of male and female rats subsequently challenged with an acute psychophysical stressor, forced swimming; their behavior in the swimming cylinder was evaluated on two consecutive days. While brain stimulation reward thresholds and response rates were unchanged by CMS exposure, significant differences in forced swim behaviors were observed between male control and CMS groups. In particular, male Long Evans rats with a history of CMS showed the largest decrease in the duration of active behaviors on the second test day, a pattern less evident in the Sprague-Dawley strain of rats, or in any of the female groups. The results suggest that the effects of depressogenic manipulations are strain and gender dependent, with male Long Evans rats most susceptible, as demonstrated by the selective reduction of struggling behaviors. Inclusion of multiple measures, including the forced swim test, would provide a better understanding of the psychopathological profile engendered by chronic exposure to mild stressors and its genetic specificity.     

Civic religion in England: Traditions and transformations

As the religious diversity of English towns and cities has grown over the past thirty years due to the establishment in some places of sizeable communities of Hindus, Muslims and Sikhs, as well as other faiths, there have been important changes to local public religion. Traditional civic ceremonies, such as Remembrance Sunday, as well as new forms of civic celebration and commemoration, are now increasingly taking account of the diversity of faiths represented in Britain. This paper examines the consequences of religious diversity for English civic religion by looking at some of the traditions of civic ceremonies in England and at the way in which they have been transformed by the changing religious landscape of towns and cities. The paper also explores some of the dilemmas and questions that have emerged both for the Church of England as well as for the other faith communities when it comes to the design and delivery of civic ceremonies.     

Satiation, capacity, and within-session responding

Responding may change substantially over the course of a session (McSweeney, Hinson, & Cannon, 1996). The role of satiation in this effect was investigated in three experiments. Experiment 1 showed that the capacity of pigeons to consume milo over a 1-hr period was relatively stable across three different methods of measurement. In Experiment 2, pigeons were divided into two groups that differed in their capacity based on one of those measures. Key pecking was then reinforced under a variable-interval 30-s schedule with hopper durations of 2 or 5 s. According to the satiation hypothesis, subjects with small capacities should satiate faster and therefore show greater decreases in food-reinforced responding than would subjects with larger capacities. The results confirmed this prediction and showed that the magnitudes of within-session decreases were better predicted by the amount an animal consumed relative to its capacity than by absolute amount alone. In Experiment 3, each pigeon was prefed 0, 5, 15, or 25 g of milo prior to each session. Consistent with the satiation hypothesis, increases in prefeeding produced lower overall response rates in the smaller capacity subjects than in the larger capacity subjects at each level of prefeeding. These experiments demonstrate the importance of a new variable in the control of behavior, and provide a recommended technique for its measurement.     

Mother Knows Best? Mother and Child Report of Behavioral Difficulties of Children of HIV-Infected Mothers

Children of HIV-infected mothers have more psychosocial adjustment difficulties than do those of noninfected mothers. In this study, child psychosocial adjustment in children of HIV-infected women is examined across the three stages of HIV-infected: asymptomatic, symptomatic and AIDS. Participants were 99 HIV-infected women and 148 noninfected women. Children were not identified as being HIV infected. Mother and child reports of behavioral difficulties are compared, and competing hypotheses about mother report of child behavior difficulties are tested. Results indicate an ascending linear trend for child report of internalizing and externalizing difficulties from the noninfected stage through increasingly severe stages of HIV-infection. According to mother report, child externalizing and internalizing difficulties are nonlinear, as mothers report an increase through the infected symptomatic stage, then a decrease in the AIDS stage. Implications for assessment, prevention and intervention in families with maternal HIV infection are discussed.