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251.
252.
Endogenous BDNF is required for long-term memory formation in the rat parietal cortex 总被引:6,自引:0,他引:6
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Alonso M Bekinschtein P Cammarota M Vianna MR Izquierdo I Medina JH 《Learning & memory (Cold Spring Harbor, N.Y.)》2005,12(5):504-510
Information storage in the brain is a temporally graded process involving different memory phases as well as different structures in the mammalian brain. Cortical plasticity seems to be essential to store stable long-term memories, although little information is available at the moment regarding molecular and cellular events supporting memory consolidation in the neocortex. Brain-derived neurotrophic factor (BDNF) modulates both short-term synaptic function and activity-dependent synaptic plasticity in hippocampal and cortical neurons. We have recently demonstrated that endogenous BDNF in the hippocampus is involved in memory formation. Here we examined the role of BDNF in the parietal cortex (PCx) in short-term (STM) and long-term memory (LTM) formation of a one-trial fear-motivated learning task in rats. Bilateral infusions of function-blocking anti-BDNF antibody into the PCx impaired both STM and LTM retention scores and decreased the phosphorylation state of cAMP response element-binding protein (CREB). In contrast, intracortical administration of recombinant human BDNF facilitated LTM and increased CREB activation. Moreover, inhibitory avoidance training is associated with a rapid and transient increase in phospho-CREB/total CREB ratio in the PCx. Thus, our results indicate that endogenous BDNF is required for both STM and LTM formation of inhibitory avoidance learning, possibly involving CREB activation-dependent mechanisms. The present data support the idea that early sensory areas constitute important components of the networks subserving memory formation and that information processing in neocortex plays an important role in memory formation. 相似文献
253.
Cardiodynamic and hemodynamic reactions to emotion-eliciting film sequences were investigated. Thirty-two healthy subjects (12 women, 20 men) were randomly assigned to one of two groups. In the first group, anger was induced using selected scenes of the film "Ragtime." In the second group, scenes of the film "The Shining" were chosen to elicit fear. A documentary film was used as a baseline stimulus in both groups. EKG, impedance cardiography, and blood pressure were continuously monitored. The two emotional conditions elicited significant differential changes in subjective ratings and cardiovascular indices. Fear was associated with decreased cardiac output, increased total peripheral resistance, and a reduction in stroke volume and myocardial contractility. Anger was associated with an increase of cardiac output and small changes in total peripheral resistance. These results support the hypothesis that discrete emotions such as fear and anger elicit differential patterns of physiological responses. 相似文献
254.
Associative and causal reasoning accounts are probably the two most influential types of accounts of causal reasoning processes. Only causal reasoning accounts predict certain asymmetries between predictive (i.e., reasoning from causes to effects) and diagnostic (i.e., reasoning from effects to causes) inferences regarding cue-interaction phenomena (e.g., the overshadowing effect). In the experiments reported here, we attempted to delimit the conditions under which these asymmetries occur. The results show that unless participants perceived the relevance of causal information to solving the task, predictive and diagnostic inferences were symmetrical. Specifically, Experiments 1A and 1B showed that implicitly stressing the relevance of causal information by having participants review the instructions favored the presence of asymmetries between predictive and diagnostic situations. In addition, Experiment 2 showed that explicitly stressing the relevance of causal information by stating the importance of the causal role of events after the instructions were given also favored the asymmetry. 相似文献
255.
The relationship between perceived loss of control and passivity in social activities in a non-handicapped institutionalized elderly population was assessed. Perceived loss of control was assessed from three different types of expectancies: low action-outcome expectancies, high situation-outcome expectancies, and low efficacy expectancies. Passivity scores were reported by the staff. The effect of these three types of expectancies on passivity was analyzed in terms of motivation and volition, which were treated as mediating variables. Overall analysis of the structural equations, as well as partial hierarchical regression analyses, showed that efficacy expectancies were good predictors of passivity, but this was not the case for the action-outcome and situation-outcome expectancies. These results lend more support to a volitional rather than to a motivational interpretation of the effect of control on passivity. The implications of these results for intervention and for a differentiated conception of expectancies are discussed. 相似文献
256.
Upward directional non-steady-state solidification experiments have been performed on a hypomonotectic Al–5.5?wt%In alloy. The alloy developed cellular as-solidified microstructure for tip growth rates, V L, higher than 0.95?mm/s. The casting regions associated with V L?<?0.95?mm/s were shown to be characterized by a microstructure formed by In droplets disseminated in the Al matrix. Tip growth rate and microstructural features, such as cell spacing and interphase spacing, have been experimentally determined. The experimental cell spacings have been compared with theoretical predictions furnished by the Hunt–Lu model. It was found that the experimental scatter lies below the minimum range of values theoretically predicted. Moreover, the experimental cell spacing evolution with V L is characterized by a ?1.1 power law. The droplets’ interphase spacing, λ, is related to the growth rate by the Jackson–Hunt relationship (λ 2 V L?=?constant). 相似文献
257.
Emotional scenes were presented peripherally (5.2° away from fixation) or foveally (at fixation) for 150 ms. In affective evaluation tasks viewers judged whether a scene was unpleasant or not, or whether it was pleasant or not. In semantic categorisation tasks viewers judged whether a scene involved animals or humans (superordinate-level task), or whether it portrayed females or males (subordinate-level task). The same stimuli were used for the affective and the semantic task. Results indicated that in peripheral vision affective evaluation was less accurate and slower than animal/human discrimination, and did not show any advantage over gender discrimination. In addition, performance impairment in the peripheral relative to the foveal condition was greater or equivalent for affective than for semantic categorisation. These findings cast doubts on the specialness and the primacy of affective over semantic recognition. The findings are also relevant when considering the role of the subcortical “low route” in emotional processing. 相似文献
258.
Happy, surprised, disgusted, angry, sad, fearful, and neutral facial expressions were presented extrafoveally (2.5° away from fixation) for 150 ms, followed by a probe word for recognition (Experiment 1) or a probe scene for affective valence evaluation (Experiment 2). Eye movements were recorded and gaze-contingent masking prevented foveal viewing of the faces. Results showed that (a) happy expressions were recognized faster than others in the absence of fixations on the faces, (b) the same pattern emerged when the faces were presented upright or upside-down, (c) happy prime faces facilitated the affective evaluation of emotionally congruent probe scenes, and (d) such priming effects occurred at 750 but not at 250 ms prime–probe stimulus–onset asynchrony. This reveals an advantage in the recognition of happy faces outside of overt visual attention, and suggests that this recognition advantage relies initially on featural processing and involves processing of positive affect at a later stage. 相似文献
259.
Paula Carneiro Leonel Garcia-Marques Angel Fernandez Pedro Albuquerque 《Memory (Hove, England)》2013,21(8):1024-1040
The main aim of this study was to analyse the roles played by associative activation and thematic extraction in the explanation of false memories using the Deese, Roediger, McDermott (DRM) paradigm. Associative lists with two different types of critical items (CIs) were used: one, the associative CI, corresponded to the word most strongly primed by the associates in the list and another, the thematic CI, was the word that best described the theme of the list. Following three different types of encoding instructions (standard, warning or strategic), false recognition for these two types of CIs was analysed in either self-paced or speeded response recognition tests. The results showed considerable levels of false memories for both types of CIs. Even without the quality of being “good themes”, associative CIs produced high levels of false recognition, which suggests that associative activation plays a prominent role in false memory formation. More interestingly, thematic CIs were more prone to be edited out, reinforcing the argument that thematic identifiability has a major role in the rejection of false memories. 相似文献
260.
Ricardo Moura Guilherme Wood Pedro Pinheiro-Chagas Jan Lonnemann Helga Krinzinger Klaus Willmes Vitor Geraldi Haase 《Journal of experimental child psychology》2013
Transcoding between numerical systems is one of the most basic abilities acquired by children during their early school years. One important topic that requires further exploration is how mathematics proficiency can affect number transcoding. The aim of the current study was to investigate transcoding abilities (i.e., reading Arabic numerals and writing dictation) in Brazilian children with and without mathematics difficulties, focusing on different school grades. We observed that children with learning difficulties in mathematics demonstrated lower achievement in number transcoding in both early and middle elementary school. In early elementary school, difficulties were observed in both the basic numerical lexicon and the management of numerical syntax. In middle elementary school, difficulties appeared mainly in the transcoding of more complex numbers. An error analysis revealed that the children with mathematics difficulties struggled mainly with the acquisition of transcoding rules. Although we confirmed the previous evidence on the impact of working memory capacity on number transcoding, we found that it did not fully account for the observed group differences. The results are discussed in the context of a maturational lag in number transcoding ability in children with mathematics difficulties. 相似文献