Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease

Parkinson's disease is predominantly a dopamine deficiency syndrome, which is produced in the brain by the loss of cells located in a small area in the ventral midbrain called the substantia nigra. Complete unilateral dopamine lesions, based on the administration of toxic substances (ie, 6-hydroxy-dopamine in rats and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice and primates) have been extremely useful in testing strategies of replacement. For example, the functional and biochemical impact of the transplanted ventral mesencephalic dopaminergic progenitors has been characterized to a large extent, using the complete lesion model in rats. Over the last decade, however, studies addressing the ability of neurotrophic factors to protect injured dopamine cells prompted researchers to make available partial and progressive lesion models to allow a window of opportunity to interfere the disease progression. Recent findings relating alpha-synuclein with Parkinson's disease pathology have opened new possibilities to develop alternative models based on the overexpression of this protein using recombinant adeno-associated viral vectors, which is valuable not only for helping to better understand its involvement in the disease process, but also to more closely resemble the neurodegeneration found in Parkinson's disease.     

Self-Regulation: Reminders and Suggestions from Personality Science

La littérature sur l’autorégulation est couramment accusée de faiblesse théorique. Il est possible que les avancées dans les recherches sur la personnalité puissent ouvrir des horizons dans ce secteur. Notre objectif est double. Nous rappelons d’abord des distinctions conceptuelles qui, bien que parfois négligées, sont essentielles dans les études contemporaines sur la personnalité et incontournables pour accéder au niveau théorique dans la littérature sur l’autorégulation. Nous disons ensuite que ceux qui font des études fondamentales et appliquées sur l’autorégulation auraient intérêt à assimiler les progrès récents concernant la dynamique et la structure de la personnalité intra‐individuelle. Nous passons en revue la théorie de base et les recherches sur l’architecture des systèmes de la personnalité intra‐individuelle, ainsi que les retombées de ce travail dans trois domaines d’application: la psychologie du travail/industrielle/organisationnelle, la psychologie clinique et la santé. The self‐regulation literature commonly is said to lack theoretical order. This paper explores the possibility that advances in personality science may foster clarity in this literature. Our goals are two‐fold. We remind readers of conceptual distinctions that are central to contemporary personality science, that are necessary to the attainment of theoretical order in the self‐regulation literature, yet that sometimes are overlooked. Secondly, we suggest that basic and applied students of self‐regulation would profit by capitalising on recent advances in personality science that explore intra‐individual personality structure and dynamics. We review theory and research on the architecture of intra‐individual personality systems and applications of this work to three domains: health, clinical, and work/industrial/organisation psychology.     

The memory-impairing effects of septal GABA receptor activation involve GABAergic septo-hippocampal projection neurons

Septal infusions of the gamma-aminobutyric acid (GABA)(A) agonist muscimol impair memory, and the effect likely involves the hippocampus. GABA(A) receptors are present on the perikarya of cholinergic and GABAergic septo-hippocampal (SH) projections. The current experiments determined whether GABAergic SH projections are involved in the memory-impairing effects of septal GABA(A) receptor activation. Experiment 1 tested whether combining septal co-infusions of subeffective doses of muscimol with scopolamine, a drug that selectively influences GABA SH projections, would produce memory deficits. Experiment 2 tested whether hippocampal infusions of a GABA(A) receptor antagonist would block the effects of septal muscimol infusions. Fifteen minutes prior to assessing spontaneous alternation (SA) or training in a multiple trial inhibitory avoidance (CMIA) task, male Sprague-Dawley rats were given septal infusions of vehicle, muscimol, scopolamine, or co-infusions of muscimol with scopolamine, or septal infusions of vehicle or muscimol combined with hippocampal infusions of vehicle or bicuculline. Septal co-infusions of muscimol with scopolamine significantly impaired SA and CMIA. Hippocampal bicuculline infusions blocked deficits produced by septal muscimol infusions in SA and attenuated deficits produced in CMIA. Combined, these findings suggest that GABAergic SH projections are involved in the memory-impairing effects of septal GABA receptor activation.     

An Orthodox View of Philanthropy and Church Diaconia

According to Orthodox theology, philanthropy refers to the loveof God toward man, which man is called to imitate by lovinghis neighbor as himself. This love consists not just in emotionsbut requires specific acts of philanthropy toward our fellowman in need. The church, in keeping the commandments of Christ,has developed throughout her history a rich philanthropic work.The diaconia of the church has taken many forms, thus respondingto historical change and to the specific human needs at differenttimes. Concentrating on diaconia for those who are in need oflong-term care, this article presents the Orthodox view of thediaconia of the church, as realized through her own philanthropicorganizations as well as through her very specific contributionto the diaconia offered by state sponsored charitable institutions.     

Orientation specificity in biological motion perception

We addressed the issue of how display orientation affects the perception of biological motion. In Experiment 1, spontaneous recognition of a point-light walker improved abruptly with image-plane display rotation from inverted to upright orientation. Within a range of orientations from 180 degrees to 90 degrees, it was dramatically impeded. Using ROC analysis, we showed (Experiments 2 and 3) that despite prior familiarization with a point-light figure at all orientations, its detectability within a mask decreased with a change in orientation from upright to a range of 90 degrees-180 degrees. In Experiment 4, a priming effect in biological motion was observed only if a prime corresponded to a range of deviations from upright orientation within which the display was spontaneously recognizable. The findings indicate that display orientation nonmonotonically affects the perception of biological motion. Moreover, top-down influence on the perception of biological motion is limited by display orientation.