Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF

Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA–BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions.     

Increasing emotional competence improves psychological and physical well-being, social relationships, and employability

This study builds on earlier work showing that adult emotional competencies (EC) could be improved through a relatively brief training. In a set of 2 controlled experimental studies, the authors investigated whether developing EC could lead to improved emotional functioning; long-term personality changes; and important positive implications for physical, psychological, social, and work adjustment. Results of Study 1 showed that 18 hr of training with e-mail follow-up was sufficient to significantly improve emotion regulation, emotion understanding, and overall EC. These changes led in turn to long-term significant increases in extraversion and agreeableness as well as a decrease in neuroticism. Results of Study 2 showed that the development of EC brought about positive changes in psychological well-being, subjective health, quality of social relationships, and employability. The effect sizes were sufficiently large for the changes to be considered as meaningful in people's lives.     

Closed systems,explanations, and the cosmological argument

Examples involving infinite suspended chains or infinite trains are sometimes used to defend perceived weaknesses in traditional cosmological arguments. In this article, we distinguish two versions of the cosmological argument, suggest that such examples can only be relevant if it is one specific type of cosmological argument that is being considered, and then criticize the use of such examples in this particular type of cosmological argument. Our criticism revolves around a discussion of what it means to call a system closed, and what it means to call an explanation complete. Our analysis makes no suppositions about the nature of the infinite, and is therefore independent of many of the issues around which contemporary discussions of the cosmological argument have tended to revolve.     

Strengthening socio‐emotional competencies in a school setting: Data from the Pyramid project

Background. Development of socio‐emotional competencies is key to children's successful social interaction at home and at school. Aims. This study examines the efficacy of a UK primary school‐based intervention, the Pyramid project, in strengthening children's socio‐emotional competencies. Sample. Participants were 385 children from seven schools in two UK cities. All children were aged 7–8 years and in school Year 3. Children were screened for socio‐emotional difficulties through the Strengths and Difficulties Questionnaire (SDQ; Goodman, 1997 ) and a multi‐agency meeting of relevant professionals before being allocated to attend a Pyramid Club intervention (n= 103) or a comparison group (n= 282). Method. A 2 × 2 mixed‐model design was used: group (intervention group vs. comparison group) × 2 time points (pre‐ vs. 12 weeks post‐intervention) with repeated measures on the time factor to investigate the impact of the Pyramid Year 3 intervention. Teachers completed the SDQ‐T4‐16 for all children pre‐ and post‐intervention to measure participants’ socio‐emotional health status. Results. As measured by the two SDQ difficulty sub‐scales of Emotional and Peer problems and the SDQ strength sub‐scale of Prosocial behaviour, post‐intervention improvements in the Pyramid attendee group were of greater magnitude than those of the comparison group. Conclusions. The Pyramid project intervention improves the socio‐emotional health of vulnerable children through promoting positive outcomes as well as reducing socio‐emotional deficits. These findings further support the inclusion of a salutogenic approach in promoting children's socio‐emotional well‐being.     

How to Respond to the Problem of Deviant Formal Causation

Recently, a new problem has arisen for an Anscombean conception of intentional action. The claim is that the Anscombean’s emphasis on the formally causal character of practical knowledge precludes distinguishing between an aim and a merely foreseen side effect. I propose a solution to this problem: the difference between aim and side effect should be understood in terms of the familiar Anscombean distinction between acting intentionally and the intention with which one acts. I also argue that this solution has advantages over an alternative that has already been endorsed in the literature: it is a better fit for the Anscombean theory, and it naturally accommodates intuitions about the moral significance of aiming vs. merely foreseeing.     

Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: Evidence of a compensatory mechanism

Brain-derived neurotrophic factor (BDNF) plays a regulatory role in neuronal differentiation and synaptic plasticity and has been linked to glucose regulation and cognition. Associations among plasma BDNF, cognition, and insulin function were explored. Forty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ. Participants received complete medical, neurological, psychiatric, and neuropsychological evaluations. IIF individuals had significantly lower plasma BDNF levels than controls, particularly females, and higher BDNF levels were associated with poorer explicit memory in IIF females, suggesting that higher levels within this group may reflect the body’s efforts to respond to damage. After accounting for age, education, and HbA1c, BDNF significantly predicted 13.1–23.5% of the variance in explicit memory in IIF women. These findings suggest that BDNF elevations within diseased groups may not always be a marker of health.     

Pain expectation,negative affect,and angry aggression

An experiment was conducted to determine if the relatively strong negative affect generated by anticipation of pain from exposure to aversive stimulation would give rise to an instigation to aggression and accompanying feelings of annoyance-irritation-anger. The 45 undergraduate women in the study were required to immerse their nondominant hand in water as they administered reward and punishment to a fellow student, supposedly as an evaluation of that person's solutions to assigned problems. In two-thirds of the cases the water temperature was unpleasantly cold, while it was much more tolerable in temperature for the remaining subjects. Half of the participants in the cold water condition and all of those in the more tolerable water temperature group has been led to expect the possibility of pain as they kept their hand in the water, whereas the remaining women (exposed to the cold water) had been alerted only to the physical sensations they would have. In accord with the findings obtained in an earlier experiment by Leventhal, Brown, Sacham, and Enquist (1979), the subjects in the cold water group expecting that they might feel pain reported experiencing the greatest discomfort. Further, consistent with Berkowitz's analysis of anger and angry aggression, these participants also reported the strongest feelings of annoyance-irritation-anger and were most punitive to the available target even though they could not attribute their discomfort to this person.     

UCS expectancy biases in spider phobics: underestimation of aversive consequences following fear-irrelevant stimuli

This paper reports the results of two studies investigating judgements made by spider phobics about the potential threatening consequences (unconditioned stimulus, UCS, expectancies) associated with their phobic stimulus, fear-relevant (FR) stimuli, and fear-irrelevant (FI) stimuli. Using a 'thought experiment' UCS expectancy paradigm, the studies reported found that (1) spider phobics reported significantly higher UCS expectancies to spider stimuli than nonphobics, (2) spider phobics consistently underestimated the probability of aversive consequences following FI stimuli and (3) this underestimation of UCS expectancies to FI stimuli in phobics was not the result of a contrast effect resulting from sequential FR and FI judgements. This differential effect may have important implications for the kind of mechanism which mediates judgements about phobic consequences. These findings suggest that the dimensions on which phobic stimuli are categorised may be 'stretched' in the case of phobics and that this gives rise to the comparative underestimation of threat associated with FI stimuli but also makes phobics more vulnerable to acquiring other phobias.