Policy Recommendations for Carrier Testing and Predictive Testing in Childhood: A Distinction That Makes a Real Difference

The genetic testing of children raises many ethical concerns. This paper examines how five position statements from Canada, UK and USA, which present guidelines for good practice in this area produce different recommendations for carrier testing and predictive testing. We find that the genetic information generated through carrier testing is routinely presented as less serious than that generated from predictive testing. Additionally, the reproductive implications of predictive testing are also routinely erased. Consequently, the papers argue strongly against predictive testing but advise caution against carrier testing in somewhat weaker terms. We argue that these differences rest on assumptions about the status of reproduction in people’s lives and on an ethical stance that foregrounds the self over others. We propose that questioning the crude and sharp distinction between carrier and predictive testing in principle may enable practitioners and parents/families to make more nuanced decisions in practice. Parts of this work have been presented in the 1st International CESAGen Conference, London, 2004, and Genetics and Society Meetings, Wales.     

Modern prejudice toward gay men and lesbian women: assessing the viability of a measure of modern homonegative attitudes within an Irish context

The authors examined the psychometric properties of the gay and lesbian versions of the Modern Homonegativity Scale (MHS-G and MHS-L) in samples of heterosexual Irish university students (Ns=179 and 353). Confirmatory factor analyses revealed that the MHS-G and MHS-L were unidimensional and factorially distinct from a well-established measure of old-fashioned homonegativity (Attitudes Toward Lesbians and Gay Men Scale [ATLG]). Alpha coefficients for both versions of the MHS were good (range = .81 to .86), with 95% confidence intervals suggesting that unsatisfactory levels of scale score reliability (i.e., alpha values < .70) were relatively implausible. As hypothesized, participants' level of modern homonegativity correlated positively with their levels of old-fashioned and modem racism, patriotism, nationalism, religious fundamentalism, social dominance, and perceived political conservatism. The authors also observed a substantial inverse correlation between modern prejudice toward sexual minorities and support for their human rights. Finally, a series of multiple regression analyses indicated that, despite their interrelatedness, modern and old-fashioned homonegativity, particularly as they pertain to gay men, possess differential predictors. Limitations of the current series of studies and the need to conduct further research on attitudes toward sexual minorities within an Irish context are also discussed.     

The effectiveness of expatriate coping strategies: the moderating role of cultural distance, position level, and time on the international assignment

On the basis of the stress and coping literature, the authors examined the diverse coping strategies used by expatriate managers in response to the problems encountered while on international assignments. It was hypothesized that although problem-focused coping strategies may be more effective than are emotion-focused coping strategies in affecting cross-cultural adjustment and intention to remain on the international assignment, the relationship is moderated by contextual factors such as hierarchical level in the organization, time on the assignment, and cultural distance. Coded semistructured interview responses from 116 German expatriates on assignment in either Japan or the United States were analyzed with moderated regression analyses. The results suggest that the effectiveness of problem-focused coping strategies in predicting cross-cultural adjustment is moderated by cultural distance and position level but not by time on the assignment. The use of problem-focused coping strategies was not related to expatriates' intention to remain on the assignment.     

Role of appearance and nonverbal behaviors in the perception of sexual orientation among lesbians and gay men

According to the zero-acquaintance paradigm gay men and lesbians possess the ability to identify other homosexuals accurately after only very brief interpersonal contact. Given the vulnerability gay men and lesbians face in terms of antigay violence and prejudice, perceptual accuracy provides self-protection. In an exploratory study, 123 respondents were classified as low, moderate, and high perceivers on the basis of their responses to a recognition index designed by the authors. Next, respondents rated on a series of 5-point Likert scales the helpfulness of several characteristics for identifying gay men and lesbians. Analysis supported the importance of eye contact for lesbians and gay men in identifying one another. For both lesbian and gay male participants, several other variables emerged as significantly helpful in identifying gay men: clothing style and fit, jewelry, facial expressions, posture, body type, walk or gait, and both the types and frequencies of gestures.     

What Do We Mean by “The Biology of Menopause”?

Most commonly, the biology of menopause is equated with the biomedical model of menopause. The biomedical model emphasizes the central importance of estrogen and has an overriding focus on disease. A broader-biological model is presented, which emphasizes the role of hormones in healthy functioning. Hormones are team players in complex, multidetermined systems that have a purpose. Hormones act in concert with other physiological systems and with sensory and social inputs. Human biology is both similar to and different from that of other animals. The implications of these assumptions for understanding menopause are discussed, especially the kinds of questions that are asked and the kinds of evidence needed before conclusions are drawn with regard to clinically significant areas. A broader-biological model of menopause provides a framework within which health-related issues can be considered from a perspective that is, on the one hand, more holistic, and on the other hand, more attentive to individual differences.     

The effects of beta-noradrenergic receptor blockade on acquisition of eyeblink conditioning in 3-month-old F344 rats

There is evidence that blocking beta-noradrenergic receptors will cause deficits in some forms of learning. We investigated the effects of systemic injections of 1, 5, and 10 mg/kg doses of propranolol on acquisition of delay eyeblink conditioning in 3-month-old Fischer 344 rats. We presented a 3-kHz, 90-dB tone as a conditioning stimulus and a 6 psi airpuff as our unconditioned stimulus to freely moving rats. We monitored eyelid activity using EMG signals. The treatment subjects were injected with either propranolol or saline 0.5 h prior to daily training sessions. Two groups of control subjects, one receiving injections of saline and one receiving injections of 5 mg/kg propranolol, received daily training sessions with unpaired and randomized presentation of the tone and airpuff. Each daily training session for the treatment groups consisted of 27 paired training trials and 3 conditioned stimulus-alone training trials. Rats injected with saline vehicle or with 1 mg/kg propranolol achieved a 60% or better learned response rate within two training sessions. Rats injected with 5 or 10 mg/kg propranolol never achieved a response rate significantly different from animals that received unpaired, random presentations of the tone and airpuff stimuli. These results agree with prior studies from our lab that have shown a dose-dependent effect of beta-noradrenergic receptor blockade on learning in rabbit eyeblink conditioning as well as in a runway, motor learning paradigm. We believe that the beta-noradrenergic system plays an important role in learning and memory in more than one cerebellar-dependent learning paradigm.     

People don't keep their heads still when looking to one side, and other people can tell

Twenty pairs of photographs were made of adults looking 25 degrees to the left and 25 degrees to the right while attempting to face forwards. The eye regions of each photograph were concealed. Twenty adults attempted to sort each pair into left-looking and right-looking pictures. They were successful 65% of the time, p < 0.001. This suggests models have difficulty looking to one side without a perceptible head turn or comparable facial cue. This previously unrecognised phenomenon has implications for research on detection of gaze.     

Structural, Relative, and Absolute Agreement between Parents' and Adolescent Inpatients' Reports of Adolescent Functional Impairment

This study assessed agreement between parents' and adolescent inpatients' scores on caretaker and self-report versions of the Functional Impairment Scale for Children and Adolescents (FISCA and FISCA-SR). Self-report data describing impairment in eight domains were collected from 375 inpatients (M age = 15.0 years, 55% females), with parent data available for 233 (62%). Confirmatory factor analysis demonstrated structural congruence between a hypothesized, three-factor model, based on a prior study of the parent FISCA, and an observed model, based on responses to the FISCA-SR (GFI = .95). Correlations (measuring relative agreement) and paired comparisons of means (assessing absolute agreement) generally identified stronger agreement in public than private domains of impairment, and greater relative than absolute agreement in covert, antisocial domains.