Acoustically evoked brain stem potential in Wilson disease

By 48 patients with Wilson's disease the brainstem acoustic evoked potentials were stated. There were 35 pathological findings (73%), 13 were normal (27%). The waves, determined by the middle and upper brainstem (Pons and Mesencephalon) showed most of all pathological changes. Those patients with forms of Wilson's disease called Pseudoskelerose and Pseudoparkinson showed the most pathological findings. But one could watch these findings by about 30% of patients in preclinical stage. This method can possibly be used for early detection of disorders of brainstem functions and in the same way it can be used for control of treatment by patients in preclinical stage.     

Clinical and cisternographic differential diagnosis between presenile dementia and Hakim syndrome

The authors compared with regard clinical and the radionuclide cisternography examination 27 patients with Hakim-Syndrome and 11 with Alzheimer-Disease. In all cases, dementia was a stable symptom. Patients with Hakim-Syndrome have an early gait disturbance, ataxia and epileptic seizures. Only in case of patients with Alzheimer-Disease we found aphasia, apraxia and psychotic disorders. 24 hours after the injection radionuclide cisternography showed ventricular retention and absence of parasagital accumulation only in patients with Hakim-Syndrome. Lighter changes (mixed cisternographic pattern) were found in patients with Alzheimer-Disease as well.     

Least squares metric,unidimensional unfolding

The partial derivatives of the squared error loss function for the metric unfolding problem have a unique geometry which can be exploited to produce unfolding methods with very desirable properties. This paper details a simple unidimensional unfolding method which uses the geometry of the partial derivatives to find conditional global minima; i.e., one set of points is held fixed and the global minimum is found for the other set. The two sets are then interchanged. The procedure is very robust. It converges to a minimum very quickly from a random or non-random starting configuration and is particularly useful for the analysis of large data sets with missing entries.This paper benefits from many conversations with and suggestions from Howard Rosenthal.     

Mental extrapolation in patterns constructed from memory

Finke and Pinker (1982, 1983) showed subjects an array of dots followed by an arrow in a blank field, and asked them to determine whether the arrow pointed to any of the previously seen dots. Response times were linearly related to the distance between the arrow and the nearest dot, suggesting that subjects spontaneously used an internal scanning or extrapolation process to perform the task. We replicate and extend this finding by varying the retention interval, and by employing a paradigm in which subjects’ eyes are closed and the arrows are described to them using a coordinate scheme. We also show that subjects are unable to predict the form of the data when the task simply is described to them. Results suggest that mental scanning along a straight path can be performed on images reconstructed from memory, and that it does not depend on the ongoing perception of a continuous surface, on physical eye movements, or on demand characteristics.     

Maternal and adolescent depressive symptoms and family conflict: An autoregressive cross-lagged examination of competing models in multi-stressed mothers and adolescents

Maternal and adolescent depression are challenges that often co-occur. Many studies have drawn bivariate associations between maternal depressive symptoms, adolescent depressive symptoms, and family conflict, but few have examined reciprocal effects. Even among extant studies, there is a lack of clarity related to directionality of influence. Three competing theoretical models may explain the relationship between maternal depressive symptoms, adolescent depressive symptoms, and family conflict, and these processes may differ by adolescents’ sex. Using three time points of data from 187 diverse mother-adolescent dyads, we fit a taxonomy of autoregressive cross-lagged structural equation models to simultaneously evaluate the competing theoretical models and also examine differences by sex using multiple-group analyses. Results indicate a symptom-driven model whereby adolescent depressive symptoms predicted increases in family conflict. Sex differences were also found. For males, but not females, greater adolescent depressive symptoms predicted subsequent increases in maternal depressive symptoms, which then predicted lower family conflict—possibly indicating maternal disengagement/withdrawal. Our findings suggest addressing adolescent depressive symptoms in order to prevent family conflict and that distinctive targets for the prevention/intervention of family conflict should account for differences by adolescents’ sex.     

Take care of egotism,and redemption will take care of itself: Comments on Tracy Llanera's Richard Rorty: Outgrowing modern nihilism

This commentary critically examines two facets of Tracy Llanera's recent book Richard Rorty: Outgrowing Modern Nihilism. First, it considers her interpretation of Richard Rorty's redemptive project. It argues that, while Llanera succeeds in resolving tensions in Rorty's public-private distinction, her account downplays the role of abnormal discourse within projects of self-creation. Second, it raises several questions about Llanera's strategy for situating this redemptive project within debates concerning existential nihilism. On her view, one ought to follow Rorty in addressing the problem of egotism instead of the problem of nihilism, since the former is prior to the latter. But it is not clear who counts as an egotist, or why egotists are especially prone to becoming nihilists. Moreover, there are reasons to think that egotism and nihilism are fundamentally different kinds of problems.