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141.
Experiments reported in this study have been performed in order to investigate cholinergic and GABA-ergic neurotransmitter systems and substance P in the realization of internal inhibition and pain reinforcement. This was accomplished during the elaboration of inhibitory and defensive conditioned reflexes to light flashes in alert, nonimmobilized rabbits. Present results together with a review of past research indicate that the cholinergic system is directly involved in transmitting the effects of pain reinforcement to neocortical neurons. Substance P, a neuropeptide, reduces the background activity of neocortical and hippocampol neurons and the response of cortical neurons to pain and positive conditioned stimuli. The cholinergic system and substance P exert a modulating effect on the elaboration of internal inhibition. Phenybut, a GABA derivative capable of penetrating the blood-brain barrier, enhances inhibitory hyperpolarization in the cerebral cortex and improves discrimination between the inhibitory and reinforcing light flashes. It appears, therefore, that the GABA-ergic system plays a leading part in the elaboration of internal inhibition. Neuronal activity and slow potential changes in response to positive conditioned and pain stimuli occur in the same direction after administering the preparations, and the dynamics of these changes is different from that in responses to inhibitory stimuli. It may be supposed on these grounds that the neurotransmitter and neuromodulator systems studied possess a considerable degree of plasticity.  相似文献   
142.
Six tasks administered on a MINC-11 minicomputer were used in studying the effects of long, continuous work periods and fatigue on physical and cognitive task performance. Submaximal physiological workload measurement was done during one of these tasks for a subject walking on a treadmill. The MINC-11 system is described, as are the six tasks programs. Four of these tasks measured various types of reaction times, another involved complex information processing, and one appraised moods, physical symptoms, fatigue, and the physiological status of subjects.  相似文献   
143.
144.
Psychology seeks to justify its claims to privilege as a social institution largely on the basis of its scientific knowledge claims. These knowledge claims tend to be based on, and to reflect a particular view about the nature of science which is under increasing challenge. This situation is discussed and some of its implications examined.  相似文献   
145.
The influence of an isolated word’s meaning on lexical decision reaction time (RT) was demonstrated through four experiments. Subjects in two experiments made lexical decision judgments, those in a third experiment pronounced the words used in the lexical decision task, and those in a fourth experiment quickly pronounced their first associative response to the words. Differences in lexical access time for the words were measured with the pronunciation task, and differences in meaning were assessed with the association task. Multiple regression analyses of lexical decision RT were conducted using associative RT, pronunciation RT, and other target word properties (printed frequency, length, instance dominance, and number of dictionary meanings) as predictor variables. These analyses revealed a relationship between lexical decision RT and associative RT after the effects of other variables had been partialed out. In addition, word frequency continued to have a significant relationship to lexical decision RT beyond that shared with pronunciation RT and the other variables. The results of these experiments indicate that at least some of the effect of word meaning and word frequency in lexical decision is attributable to a decision stage following lexical access.  相似文献   
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147.
The effect of environmental enrichment on normal rats, rats that received hemidecortication at birth, and rats that received hemidecortication when adult was studied in the Morris water task, which is a spatial navigation task requiring the use of distal cues for successful performance. Enrichment was achieved by housing the rats for 90 days in a large outdoor compound that was designed to model a natural environment. Adult hemidecorticated lab-raised rats were severely impaired in the acquisition of the task but neonatally hemidecorticated rats, although also impaired, showed significant sparing. Postsurgical, but not presurgical, enrichment of adult hemidecorticated rats significantly enhanced their recovery. Enrichment had little effect on neonatally decorticated rats or on normal rats. Although there were no gross anatomical changes associated with enrichment, the paradigm provides both a robust phenomena and a cortically dependent task that is ideal for investigating the processes in the remaining intact hemisphere that must support recovery.  相似文献   
148.
149.
This paper brings together, in the context of individual-differences theory, two developing themes in schizophrenia research. One concerns the manifestation, in normal people, of ‘psychotic’ characteristics and their measurement using scales which, unlike the Eysenck P scale, draw their items from the clinical symptomatology of psychosis. Recent work on the so-called ‘borderline states’ is considered especially relevant and a new two-scale questionnaire (STQ) is described which was modelled on the current distinction, in DSM-III, between ‘schizotypal personality disorder’ and ‘borderline personality disorder’. The second theme addressed concerns the possible biological basis of individual differences in ‘schizotypy’. It is argued, in the light of some emerging views about the nature of schizophrenia, that this may lie in the functional and structural properties of hemisphere organization. A suggested strategy for evaluating this theory is an examination of the performance of schizotypal normal Ss on tests of hemisphere function.  相似文献   
150.
This study examined the impact of nonsexist curricula and teacher's sex on children's sex role learning. Thirty-two boys and 32 girls, aged three to five, were equally divided among four programs: nonsexist curriculum, female director; nonsexist curriculum, male director; control curriculum, female director; and control curriculum, male director. Sex role discrimination and preference were measured at the beginning and end of a six-month period. Exposure to the nonsexist curriculum produced significantly greater reductions in sex stereotyping on all measures than exposure to the control curriculum. Moreover, children in the male-directed nonsexist program displayed greater decreases in stereotypic knowledge and preference for sex-typed children's activities than those in the female-directed nonsexist program, while children in the male-directed control program showed more stereotypic increases on these measures than their counterparts in the female-directed control program. Finally, children under the direction of an opposite-sex teacher exhibited less stereotypic changes in preference for adult activities than children under the direction of a same-sex teacher. Implications for early childhood programs are discussed.This research was partially supported by an Oregon State University Foundation grant from the Shell Foundation and a grant from the Milne Computer Center.  相似文献   
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