Jewish medical ethics in the care of the cancer patient

The care of the patient with cancer requires the development not only of a medical plan, but an ethical plan as well. This plan should integrate the physician's and the patient's perceptions of medical and ethical propriety. Jewish biomedical ethical principles are based on the teaching of the Old Testament and its various interpretations. In this paper, I discuss how these principles can be used to help guide the physician caring for the patient with cancer. Other ethical systems could be applied in a similar fashion.     

The precaution adoption process

This article presents a critique of current models of preventive behavior. It discusses a variety of factors that are usually overlooked-including the appearance of costs and benefits over time, the role of cues to action, the problem of competing life demands, and the ways that actual decision behavior differs from the rational ideal implicit in expectancy-value and utility theories. Such considerations suggest that the adoption of new precautions should be viewed as a dynamic process with many determinants. The framework of a model that is able to accommodate these additional factors is described. This alternative model portrays the precaution adoption process as an orderly sequence of qualitatively different cognitive stages. Data illustrating a few of the suggestions made in the article are presented, and implications for prevention programs are discussed.     

Spatial coding in the processing of anaphor by good and poor readers: Evidence from eye movement analyses

An experiment that examined the way in which young readers deployed eye movements while reading sentences and while answering questions containing either a pronominal or noun anaphor is reported. To evaluate the possible causal role played by differences in inspection strategies between readers of above- and below-average reading skill, a third“age control” group of younger children was also tested. This group was matched on absolute reading ability with the less skilled group of older children, and on relative reading ability (i.e. reading quotient) with the more skilled group. Differences in inspection strategy were apparent between the groups of good and poor readers. Good readers launched more selective reinspections, whereas the poorer readers were more inclined to engage in“backtracking” and appeared to make less use of the displayed text. In every case there was a marked similarity in the behaviour of the good readers and the“age controls”. These results suggest that the ability to code the spatial location of words in a sentence, and, where necessary, to use this information to launch accurately targetted selective reinspections of previously read text, plays a crucial role in the development of skilled reading performance.     

Focused search of semantic cases in question answering

Three experiments tested the hypothesis that people can execute focused searches of semantic cases when answering questions about complex facts, such as “the teacher watered the peas, the corn, and the lettuce with the hose.” In Experiment 1, answer time varied mainly with the number of concepts in the relevant or focused case, supporting the hypothesis. Experiment 2 indicated that the irrelevant case undergoes some processing. Experiment 3 confirmed that search in Experiments 1 and 2 focused on semantic cases rather than on taxonomic categories. It is proposed that focused memory search has a high probability of retrieving the relevant case and a low probability of retrieving the irrelevant case. In the latter event, the irrelevant concepts receive full processing.     

A maturation effect in response inhibition in the rat

The finding that there are maturational differences between the ability to learn and to perform a task requiring young Wistar rats to inhibit a response was examined. Using an operant task, different from that employed in the previous studies, it was established that the finding was not task specific. The relative contribution of different periods in the early training stage to later savings in learning was also examined. It was confirmed that there is an early performance deficit by weanling rats on tasks requiring them to inhibit a previously learned response in the presence of a discriminative cue. Rats given early training on the task during this period of performance deficit nevertheless showed significant savings in later learning of the task, indicating that they had learned as much in that stage as they would have if given the same training at an age when performance is at the adult level. It was revealed that despite age-related differences in performance it was not so much the age at which early training took place as the amount of training given that affected later savings. The results are discussed in light of evidence of similar differences between the learning and performance of discrimination tasks exhibited by young children.     

Modulation of male mouse genital sniff, attack, and mount behaviors by urogenital substances from estrous females

The modulation of attacks, genital sniffs, and mounts in male SJL/J mice by ovarian-dependent urogenital substances in the urine voided by estrous females was examined. Urogenital substances were applied onto the external urogenital areas of ovariectomized mice. When compared with urine voided by estrous females, which stimulated genital sniffing, mounting, and reduced aggression, bladder urine was ineffective. Genital sniffing and mounting was stimulated by estradiol-17 beta, vaginal fluids, and preputial extract. Aggression was reduced by estradiol-17 beta, urethral catheterized urine, and vaginal fluids. Preputialectomy reduced, but did not eliminate, urinary stimulation of genital sniffing and mounting. Preputial extract stimulated aggression. Urogenital substances from ovariectomized females were ineffective in reducing attacks and stimulating genital sniffs and mounts. It was concluded that the ovarian-dependent chemosignals in the urine voided by estrous females are contributed by the urethra, vagina, and preputial gland, perhaps in part through the excretion of unconjugated estrogens.     

Brain weights correlate with behavioral parameters in individual inbred mice housed in a common and enriched environment

Fifty 8-week-old Balb/c mice were individually identified and housed together in a large and enriched environment for 5 months. Maze and open field exploration, response to an aversive noise, swimming, and induced grooming tests were applied to each mouse in an initial search for possible relationships between brain morphology and spontaneous behavior in isogenic individuals living in a complex social and physical environment. The tasks generated 39 quantitative behavioral indices which include locomotion, rearing, still, and grooming bout frequencies, latencies, total, and mean bout durations. At the end of the tests, the 7-month-old mice were sacrificed and the fresh weights of their whole brain, cerebellum, brain stem, diencephalon, telencephalon, and prosencephalon were rapidly obtained. Behavioral data have wide variations and do not adjust to normal population distributions. Means of the same parameter differ between tests. A Spearman correlation matrix of all data yielded many significant correlations between indices of the same task which can be interpreted in terms of time budget and sequence probability. Significant correlations between indices of different tests suggest diverse emotionalities, exploratory strategies, and motor skills. The correlations between body and brain weights and among separate brain regions were not significant. There were several low but significant correlations between brain weights and behavioral indices. Such correlations, the resulting factors, and significant behavioral differences between mice with large and small brains suggest that mice displaying low motor activity in novel environments have larger brains and forebrain/hindbrain ratios than mice with high activity, and that animals with high scores of some specific behaviors have larger brain areas physiologically related to such behaviors.(ABSTRACT TRUNCATED AT 250 WORDS)