Impairment of spontaneous alternation performance by an NMDA antagonist: attenuation with non-NMDA treatments.

N-Methyl-D-aspartate (NMDA) receptor antagonists disrupt learning on a variety of tasks. Previous findings indicate that glucose, naloxone, and physostigmine ameliorate learning deficits produced by several treatments. The present experiment examines whether these agents also reverse the amnestic effects of NMDA receptor blockade. Mice were tested for spontaneous alternation performance in a Y-maze. The animals received either saline or the NMDA antagonist, NPC 12626 (35 mg/kg, IP), 50 min prior to testing and received an additional injection of saline, glucose, naloxone, or physostigmine 30 min prior to testing. NPC 12626 significantly decreased alternation scores. Glucose (250 mg/kg), physostigmine (0.01 mg/kg), and naloxone (1 mg/kg) reversed the effects of NPC 12626. Thus, impairments of learning after NMDA receptor blockade share with other amnestic conditions the susceptibility to attenuation by glucose, naloxone, and physostigmine.     

Conditioned taste aversions support drug discrimination learning at low dosages of morphine.

The present experiment shows that a conditioned taste aversion procedure can support discrimination learning at dosages of morphine comparable to those required to produce motivational effects. Sprague-Dawley rats were injected with 4.0 mg/kg morphine sulfate prior to a saccharin-lithium chloride pairing, and physiological saline prior to a saccharin-saline pairing. The rats avoided the saccharin solution following the administration of morphine and consumed significantly more saccharin following saline administration after four discrimination cycles. After this initial discrimination the subjects were trained with progressively lower doses of morphine. Discrimination learning was apparent at doses of 2.0, 1.5, 1.0, 0.75 and 0.5 mg/kg. Animals initially trained with 1.0 mg/kg morphine also learned the discrimination but required 10 training cycles. After this initial discrimination the subjects were trained with progressively lower dosages of morphine and showed a discrimination at a dosage of 0.5 mg/kg.     

Reinstatement of latent inhibition following a reminder treatment in a conditioned taste aversion paradigm.

Reminder treatments have been shown to facilitate the retrieval of a variety of conditioned responses. Whether or not similar results would occur with an experimental paradigm which involves primarily memory for a stimulus, i.e., where no particular response is specified, is unclear. Accordingly, using Sprague-Dawley rats, we employed a latent inhibition paradigm with a long (10 days) retention interval between sucrose (CS) preexposure and sucrose-illness pairing (training). The results demonstrated a loss of latent inhibition following the 10-day retention interval suggesting "forgetting" of the CS preexposure. However, placing a single reminder exposure to the CS within the preexposure-to-training interval reinstated the preexposure effect. Controls indicated that in the absence of the initial preexposure the reminder per se did not produce latent inhibition. Thus, a reminder can reinstate a stimulus attribute (flavor representation) and explicit conditioned responses.     

TOWARD A FEMINIST UNDERSTANDING OF WOMEN AND POWER

Both psychologists and feminists believe power is an important and ubiquitous concept, yet its definition and scope eludes both groups. In this introduction to a special issue on women and power, we suggest three points to help organize and interpret research in the area. First, definitions of power should center around the distinction between "power-over," the domination and control of one person or group over another, and "power-to" or personal empowerment. Second, power can be analyzed at different levels—societal, organizational, interpersonal, and individual—and, importantly, these levels interact. Third, power differences frequently underlie what appear to be gender differences in behavior; as society is currently configured, power and gender are never independent. Although the articles in this special issue often ask more questions than they answer, the present volume adds a feminist perspective to the psychological study of power.     

It's never too late to change: A group psychotherapy experience for older women

Group psychotherapy in a mixed gender group is seen as useful for treatment of the unique existential and emotional problems of the older woman. This article describes the first year of a psychotherapy group for older adults, four women and three men in their early fifties to late sixties. Some issues discussed unique to this age group were loss, isolation, changing body image, and changed political views. There were differences in reactions between the men and women. The major value of group psychotherapy for older women is seen as providing a safe arena for exploring current issues, integrating a sense of self, enhancing self-worth, and overcoming isolation and despair.     

An exploratory study of videotapes of long-term group psychotherapy of outpatients with major and chronic mental illness

This study explored patterns emerging in videotaped sessions of group psychotherapy with seven outpatients of a large mental health facility. The 22 sessions spanned the 12th to 27th months of the group's existence. Group members had long histories (25–50 years) of symptoms characteristic of schizophrenia. Each session was rated on the Group Environment Scale. One session from a group in its earlier stages was also rated on the same instrument to give some indication of baseline patterns. Analyses of changes across the 15 months were not statistically significant. However, some GES subscales, including Cohesion, Independence, and Self-Discovery, showed relatively high mean levels across the 15-month period. These elevations are discussed as suggesting the codevelopment of orientations that have sometimes been viewed as incompatible and unattainable for schizophrenics. Interpreted clinically, the GES patterns help to elaborate recent findings about the relatively good success of long-term group therapy with such populations. The study, although merely suggestive, illustrates the potential for gleaning solid and clinically useful data from group psychotherapy research.The authors would like to thank Drs. Jill Rierdan, Nina Fieldsteel, Joseph Christy, and an anonymous reviewer for their suggestions, Kendra Bryant for serving as the reliability rater, and Janet Eltinge for her skilled videotaping.     

Adult age differences in memory for routes: effects of instruction and spatial diagram.

Free-recall and multiple-choice measures of memory for landmarks, sequential order, turns, and route configurations were obtained from younger and older adults after they viewed slides of 2 overlapping routes. Instructions focused attention on either the contents of the slides or on the course of the path; a control condition provided no orientational instructions. Half the subjects viewed maplike diagrams of the joint spatial configuration. Age interacted with instruction only for multiple-choice tests of landmark memory. Age interacted with diagram for each of the other 3 route memory components, although the generality of this interaction across instruction condition depended on whether free-recall or multiple-choice tests were used. The results suggest that route memory may involve both scene and layout representation, which may be differentially sensitive to age and presentational variables.     

Adult age differences in short-term memory and subsequent long-term memory for actions.

Short-term memory for actions was investigated for young adult and elderly adult subjects with the Brown-Peterson procedure at retention intervals of 0 and 15 s. The short-term memory trials were followed by the long-term recall of the prior to-be-remembered actions. The 15-s retention interval was filled either with no activity or with 1 of 3 different interfering activities. Verbal interference had little effect on short-term memory at either age level. Actions performed in the interval either by the subjects or by the experimenter produced significantly lower recall scores at each age level, with the decrement being more pronounced for the elderly than for the young subjects. The long-term memory results indicated that successful short-term recall enhanced later long-term recall, regardless of age level.