Biology of elderly suicide.

Most studies of suicide in younger patients have demonstrated significant alterations in the serotonin system. Although a high percentage of completed suicides occur in late-life, to date very few studies of the biology of suicide have focused on this age group. This chapter describes age-related changes in the central nervous system pertinent to the biology of suicide, then reviews post-mortem biological studies of the brains of suicides and suicide attempters. As suicide attempts in the elderly are characterized by the use of violent means, biologic studies of impulsive violence are discussed. Finally we describe data on the effect of degenerative diseases on the serotonin system and the possible link to increased suicidal behavior in affected patients. This review underscores the need for further study of the biology of suicide in the geriatric age group.     

Are rats short-sighted? Effects of stimulus distance and size on visual detection

Behavioural evidence concerning short-sightedness in rats is apparently conflicting: in some experiments rats have performed poorly with visual stimuli further than about 60 cm distant, while in others they have made efficient use of more distant cues, for example to find their way through mazes. However, in the experiments suggesting short-sightedness, the physical size of the stimuli was not varied, so that stimulus distance and visual angle were confounded. In the present experiment, therefore, the size and distance of the stimuli to be detected were varied independently. Over the range tested (30-160 cm), distance was found to produce relatively slight effects on the smallest detectable visual angle, and these tended to diminish with practice. Thus, no good evidence was found for short-sightedness in rats up to 160 cm, a finding consistent with current views of the structure and image-forming capacities of the rat's eye. The smallest detectable targets were, however, surprisingly large in view of the rat's visual acuity (which is about 1c/deg): at the distances tested, animals required considerable training to run reliably to targets subtending less than 5-10° of visual angle. Difficulties in responding to stationary stimuli of this size are likely to restrict severely the use that rats make of vision both in the laboratory and in their natural surroundings.     

Suppression of Regional Cerebral Blood during Emotional versus Higher Cognitive Implications for Interactions between Emotion and Cognition

Brain mapping studies using dynamic imaging methods demonstrate areas regional cerebral blood flow (rCBF) decreases, as well as areas where increases, during performance of various experimental tasks. Task holds for both sets of cerebral blood flow changes (CBF), providing the opportunity to investigate areas that become and “activated” in the experimental condition relative to control state. Such data yield the intriguing observation that in areas in emotional processing, such as the amygdala, the posteromedial cortex, and the ventral anterior cingulate cortex, although flow as expected during specific emotion-related tasks, flow decreases performance of some attentionally demanding, cognitive tasks. Conversely, in some of the areas that appear to subserve cognitive functions, as the dorsal anterior cingulate and the dorsolateral prefrontal cortices, increases while performing attentionally demanding cognitive tasks, but during some experimentally induced and pathological emotional Although the specific nature of such reciprocal patterns of regional remains unclear, they may reflect an important cross-modal interaction during mental operations. The possibility that neural activity is less in areas required in emotional processing during some higher cognitive processes holds implications for the mechanisms underlying interactions cognition and emotion. Furthermore, the possibility that neural in some cognitive-processing areas is suppressed during intense states suggests mechanisms by which extreme fear or severe may interfere with cognitive performance.     

AN EMPIRICAL APPRAISAL OF THE PRCA FOR MEASURING ORAL COMMUNICATION APPREHENSION

Since 1970 about 80% of the research on oral communication apprehension has used one of two versions of McCroskey's Personal Report of Communication Apprehension. The original 20-item PRCA was introduced for the purpose of measuring apprehension beyond the traditional public speaking context. Although the PRCA-20 is reliable, some serious criticism of it has centered on its ability to tap interpersonal behavior outcomes. In an attempt to bolster its interpersonal applicability, five “interpersonally-oriented” items were added to form the PRCA-25. The studies reported herein demonstrate that both versions fail to possess sufficient reliable variance to be applicable to contexts other than public settings. In addition, it was found that the interpersonal items are a separate component of the PRCA, and as such, do not justify being treated equal in terms of additivity and, therefore, reduce the construct integrity of the PRCA.     

Assessing potential reinforcement-like effects of brief stimuli unrelated to food reinforcers

It is widely assumed that reinforcers are biologically relevant stimuli, or stimuli that have been associated with biologically relevant stimuli. However, brief, arbitrary stimuli have also been reported to have reinforcement-like effects, despite being unrelated to biologically relevant stimuli like food. The present study explored the potential reinforcement-like effects of brief stimuli across 5 experiments. In Experiments 1 through 4, pigeon subjects responded for food reinforcement and brief stimulus presentations in a 2-component multiple schedule. Neither baseline response rates nor resistance to change during disruption tests were systematically greater in a component with versus without brief stimulus presentations. Increasing the rate and duration of brief stimulus presentations in Experiment 4 did not reveal reinforcement-like effects when compared directly with food. In Experiment 5, pigeons chose between independent terminal links in a concurrent-chains procedure. Across conditions, varying the location, duration, and rate of brief stimulus presentations in the terminal links had no systematic effects on preference. In contrast, varying rates of food reinforcers resulted in large and reliable shifts in preference. Therefore, the present study found no systematic evidence that brief stimuli unrelated to food reliably increase response rates, resistance to change, or preference. These data demonstrate the value of systematic replication, and a behavioral momentum approach to assessing potential reinforcement-like effects.