The neural basis of autobiographical and semantic memory: new evidence from three PET studies

A novel, neuropsychologically informed paradigm (extended retrieval of events in response to a cue word) was used to investigate the neural basis of autobiographical and semantic memory. Contrasting retrieval of autobiographical memories with retrieval of semantic facts (ABM-SEM) in 24 subjects across three PET studies revealed bilateral involvement of the middle temporal gyrus (BA 21) and medial frontal cortex (BA 9/10). The opposite contrast, SEM-ABM, resulted in increased regional cerebral blood flow in left posterior temporal regions (BA 37) and left prefrontal cortex (BA 45/46). Laterality maps suggest that the bilateral pattern seen in our studies, but not often in other neuroimaging investigations, reflects the use of a task stressing retrieval of specific personal events. Further comparisons revealed that the activation in the right anterior temporal lobe during autobiographical recall was virtually identical to that seen during retrieval of information about famous people or events in contrast with retrieval of general semantic facts. These findings suggest that the retrieval of an autobiographical event requires participation from conceptual knowledge, and that this type of knowledge is bilaterally distributed in the temporal lobes.     

An effective approach to violence prevention: traditional martial arts in middle school

This study replicated and extended the design and outcome measures of several small studies. In these studies, juveniles at high risk for violence and delinquency showed decreased violence and positive changes in psychological risk factors after being required to take a school-linked course in traditional martial arts. In the present study, 60 boys in a large urban middle school were required to take a traditional martial arts course in their school. They were paired on problematic behavior profiles and assigned to a treatment group or to a wait-list control group. Thirty classes, three per week (45 minutes each), were taught by a master of Koga Ha Kosho Shorei Ryu Kempo and his assistant (neither was a public school teacher). Results are reported here for 14 variables from the following measures: four teacher rating scales from the Sutter-Eyberg Student Behavior Inventory, five self-report scales of the Piers-Harris Self-Concept Scale, four computerized measures of attentional self-control from the Intermediate Visual and Auditory Continuous Performance Test, and a count of permanent expulsions from school. The treatment students improved over baseline on 12 variables, while the controls improved on 5 by small amounts and deteriorated from baseline on 8, including teacher-rated violence. There were significant differences between the groups on self-reported happiness and schoolwork and on one measure of attention. After controls took the course, their scores resembled the postcourse scores of the treatment group. Importantly, the control group's increase in teacher-rated violence was reversed. Both groups were then pooled to compare baseline and postcourse teacher ratings. Their scores improved significantly in the areas of resistance to rules, impulsiveness, and inappropriate social behavior. There was also improvement in regard to violence, but the change in scores was not statistically significant. Follow-up on teachers' ratings showed that improvement remained, and in some cases increased, four months after completion of the course. Interestingly, all 6 permanent expulsions were among the control group students who had not yet taken, or had only begun taking, the martial arts course.     

Is a picture worth a thousand words? Evidence from concept definitions by patients with semantic dementia

Nine patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) were asked to define concrete concepts either from presentation of a picture of the object or from its spoken name. As expected, the patients with the most severe semantic impairment produced the least detailed definitions, and the quality of the definitions overall was significantly related to concept familiarity. Further analyses of the definitions were designed to assess two key theoretical aspects of semantic organization. (i) Do objects and their corresponding names activate conceptual information in two neuroanatomically separable (modality-specific) semantic systems? If so, then-apart from any expected commonality in performance attributable to factors such as concept familiarity-one would not predict striking item-specific similarities in a patient's picture- and word-elicited definitions. (ii) Do sensory/perceptual features and more associative/functional attributes of conceptual knowledge form two neuroanatomically separable subsystems? If so, then one would predict significant dissociations in the prominence of these two types of information in the patients' definitions. The results lead us to favor a model of the semantic system that is divided by attribute type but not by modality.     

A delivery system for olfactory stimuli

This paper describes the design of a new method for controlling and administering olfactory stimuli—namely, thehood system. The hood system involves a stream of vaporized odor (at known concentrations) mixed with odorless air and pumped (at a constant flow rate) into an oxygen therapy hood. It is designed to be used with odorants in solution, such as essential oils, as the olfactory stimulus. The use of oxygen therapy hoods allows for the precise control of a constant concentration of odorized air over time, while allowing subjects to breathe normally. The hood system provides a natural administration of olfactory stimuli and the exact determination of the stimulus concentration. The use of this system will allow experimental conditions to be completely defined and results and replication studies to be accurately interpreted. The hood system is portable, cost effective, and constructed from readily available components. It is proposed that the hood system could be adopted to suit a wide range of olfactory research, particularly that in which the effects of chronic exposure to olfactory stimuli on cognition are examined.     

A systematic review of training programs for parents of children with autism spectrum disorders: Single subject contributions

Aim: The purpose of this systematic review was to examine research utilizing single subject research designs (SSRD) to explore the effectiveness of interventions designed to increase parents' ability to support communication and social development in children with autism spectrum disorders (ASDs). Method: Included studies were systematically assessed for methodological quality (Logan et al., 2008; Smith et al., 2007) and intervention effects. Data examining participant characteristics, study methodology, outcomes, and analysis were systematically extracted. Results: Eleven SSRD parent-training intervention studies examining 44 participants with ASD were included. Overall, the studies were of moderate quality and reported increases in parent skills and child language and communication outcomes. Interpretation: The results supported by improvement rate difference (IRD) analysis indicated several interventions demonstrated positive effects for both parent and child outcomes. However, limited generalization and follow-up data suggested only one intervention demonstrated parents' accurate and ongoing intervention implementation beyond training.     

Does Children's Colour Use Reflect the Emotional Content of their Drawings?

When children draw in clinical contexts, clinicians sometimes rely on children's colour use to make inferences about their emotional reaction to the subject of the drawing. Here, we examined whether children use colour to portray emotion in their drawings. In Experiment 1, children indicated their colour preferences and then coloured in outlines of figures characterized as nasty or nice. Children also drew complex, multi‐coloured pictures about their own happy or sad experiences. In Experiment 2, hospitalized children drew about being worried or scared in hospital and about their positive experiences. In both experiments, we examined the relation between children's colour use and their colour preferences. Three‐ to 10‐year‐old children used more preferred colours to colour in the nice outline. Although they were more likely to use non‐preferred colours to colour in the nasty outline, they tended to used a mix of preferred and non‐preferred colours. When both normal and hospitalized children produced drawings about positive and negative events, there was no relation between children's colour choices and their colour preferences; children primarily used preferred colours. These data suggest that clinicians should exercise extreme caution when interpreting the meaning of colour in children's drawings. Copyright © 2011 John Wiley & Sons, Ltd.     

Interval, blocking, and marking effects during the development of schedule-induced drinking in rats

Schedule-induced drinking (SID) can occur when food-deprived rats are given access to water while receiving pellets on an intermittent reinforcement schedule. These conditions can increase water intake excessively. The possible role of adventitious reinforcement of postpellet drinking was assessed by testing whether response-reinforcer contiguity, the relative predictiveness of a response, and whether it is marked are important in the development of SID. Rats exposed to a short interpellet interval acquired SID most rapidly, with this acquired drinking response maintained when animals were transferred to a longer interpellet interval, thus indicating an easy-to-hard effect (Experiment 1). Further experiments demonstrated that a stimulus (a brief-flashing house light) occurring prior to pellet delivery could block the acquisition of SID (Experiment 2), while a lick-contingent tone, intended to increase the associability of this response, produced more rapid acquisition of SID (Experiment 3). Analysis of lick distributions revealed that licking became concentrated in the first half of an interpellet interval only after several sessions. Overall, the results indicated that similar factors affect the acquisition of both SID and instrumental conditioning with delayed reinforcement, as is consistent with a superstitious conditioning account of SID development.     

Reliability of upper extremity kinematics while performing different tasks in individuals with stroke

Assessments of upper extremity performance typically include qualitative rather than quantitative measures of functional ability. Kinematic analysis is an objective, discriminative measure that quantifies movement biomechanics; however, the use within the poststroke impaired upper extremity is not well established. The purpose of this study was to examine the reliability of upper extremity kinematics in 18 individuals with stroke and 9 healthy controls. Participants performed reaching and grasping tasks over 2 separate days and metrics included movement time, peak velocity, index of curvature, trunk displacement, maximum aperture, and percentage of the movement cycle where maximum aperture occurred. The results showed moderate to high intraclass correlation and low standard error of measurement values for most variables, demonstrating that kinematic analysis may be a feasible and useful tool to quantify upper extremity movement after stroke.     

The Holy Trinity: Between Mystery and Analysis

Two significant strands of trinitarian theology, the analytic and the apophatic, emphasize considerations of logical consistency and divine incomprehensibility respectively. This article seeks to mediate between these two seemingly opposed lines of thought by arguing for a fuller awareness of the particular mystery associated with the trinitarian notion of ‘person’. By specifying more closely this mystery of divine personhood, I qualify an overzealous apophaticism and also open up some scope for analytic approaches. I then highlight an implication of the mystery of divine personhood that any proposition linking together person‐language and nature‐language (e.g. ‘the Son is God’) necessarily contains its own mystery and cannot be understood in analytic terms.