Applications of gene targeting technology to mental retardation and developmental disability research

The human and mouse genome projects elucidated the sequence and position map of innumerous genes expressed in the central nervous system (CNS), advancing our ability to manipulate these sequences and create models to investigate regulation of gene expression and function. In this article, we reviewed gene targeting methodologies with emphasis on applications to CNS development and neurodevelopmental disorders.     

Coming Full Circle: A Reciprocal-Engagement Model of Genetic Counseling Practice

As genetic health care and genetic testing expand from primarily addressing conditions that are exclusively genetic in nature to common diseases with both genetic and environmental components, the scope of genetic counseling has grown. Identification and utilization of a normative model of practice defined by members of the profession is critical as genetic services become more commonplace in medical care. The purpose of this paper is to describe the results of a consensus conference convened to define a model of genetic counseling practice based on the guidance of educators and leaders in the profession. Twenty-three program directors or their representatives from 20 genetic counseling graduate programs in North America listened to presentations and participated in group discussions aimed at determining the elements of a model of practice, including tenets, goals, strategies, and behaviors for addressing patients’ genetic concerns. Their discussion is summarized, training implications and research recommendations are presented, and a model of practice that extends their ideas is proposed.     

Probability Biases in Genetic Problem Solving: A Comparison of Undergraduates, Genetic Counseling Graduate Students, and Genetic Counselors

Heuristics are mental shortcuts that aid people in everyday problem-solving and decision-making. Although numerous studies have demonstrated their use in contexts ranging from consumers’ shopping decisions to experts’ estimations of experimental validity, virtually no published research has addressed heuristics use in problems involving genetic conditions and associated risk probabilities. The present research consists of two studies. In the first study, 220 undergraduates attempted to solve four genetic problems—two common heuristic problems modified to focus on genetic likelihood, and two created to study heuristics and probability rule application. Results revealed that the vast majority of undergraduates used heuristics and also demonstrated a complete misuse of probability rules. In the second study, 156 practicing genetic counselors and 89 genetic counseling students solved slightly modified versions of the genetic problems used in Study 1. Results indicated that a large percentage of both genetic counselors and students used heuristics, but the counselors demonstrated superior problem-solving performance compared to both the genetic counseling students and the undergraduates from Study 1. Research, training, and practice recommendations are presented.     

On the validity and utility of discriminating among impulsivity-like traits

The ability to make precise distinctions among related personality constructs helps clarify theory and increases the utility of clinical assessment. In three studies, the authors evaluated the validity of distinctions among four impulsivity-like traits: sensation seeking, lack of planning, lack of persistence, and urgency (acting rashly when distressed). Factor analyses indicated that lack of planning and lack of persistence are two distinct facets of one broader trait, whereas urgency and sensation seeking are both very modestly related to each other and to the planning/persistence measures. The authors developed interview assessments of each, and multitrait, multimethod matrix results indicated clear convergent and discriminant validity among the constructs. The distinctions among them were useful: The traits accounted for different aspects of risky behaviors. Sensation seeking appeared to relate to the frequency of engaging in risky behaviors, and urgency appeared to relate to problem levels of involvement in those behaviors.     

Using temporal cohesion to predict temporal coherence in narrative and expository texts

We investigated the linguistic features of temporal cohesion that distinguish variations in temporal coherence. In an analysis of 150 texts, experts rated temporal coherence on three continuous scale measures designed to capture unique representations of time. Coh-Metrix, a computational tool that assesses textual cohesion, correctly predicted the human ratings with five features of temporal cohesion. The correlations between predicted and actual scores were all statistically significant. In a complementary study, we explored the importance of temporal cohesion in characterizing genre. A discriminant function analysis, using Coh-Metrix temporal indices, successfully distinguished the genres of science, history, and narrative texts. The results suggested that history texts are more similar to narrative texts than to science texts in terms of temporal cohesion.     

Sexual Utterances and Common Life

The essay discusses sexual activity as forms of communication that are constitutive of social practices. In this context, marriage is understood as a representative practice of the church, nothing more and nothing less. The essay draws on Thomas Nagel's essay, 'Sexual Perversion', and Robert Solomon'ls 'Sexual Paradigms' for its account of sexual communication. For its critical perspective, it frames questions about sex with Herbert McCabe's account of bodily utterances as 'ways of entering into social life'     

Religiosity and Ethical Ideology of Physicians: A Cross-Cultural Study

In this study of ethical ideology and religiosity, 1,255 physicians from Canada, China, Ireland, India, Japan and Thailand participated. Forsyth’s (1980) Ethical Position Questionnaire and Rohrbaugh and Jessor’s (J Pers 43:136–155, 1975) Religiosity Measure were used as the survey instruments. The results demonstrated that physicians from India, Thailand and China reported significantly higher rates of idealism than physicians from Canada and Japan. India, Thailand and China also scored significantly higher than Ireland. Physicians from Japan and India reported significantly higher rates of relativism than physicians from Canada, Ireland, Thailand and China. Physicians from China also reported higher rates of relativism than physicians from Canada, Ireland and Thailand. Overall, religiosity was positively associated with idealism and negatively associated with relativism. This study is the first to explore the differences between ethical ideology and religiosity among physicians in an international setting as well as the relationship between these two constructs. Both religiosity and ethical ideology are extremely generalized, and the extent to which they may impact the actual professional behaviour of physicians is unknown. This paper sets up a point of departure for future research that could investigate the extent to which physicians actually employ their religious and/or ethical orientation to solve ambiguous medical decisions.     

The Irrationality of Physicalism

This paper argues, not that physicalism is wrong, but that it is irrational. The paper defines standards of rationality, both metaphysical and epistemological, that physicalism necessarily inherits from science. Then it assesses physicalist efforts to naturalize consciousness in light of these. It concludes that physicalism allows its metaphysics to outrun its epistemology, in defiance of applicable standards, revealing a fundamental incoherence in the doctrine. The paper also briefly reviews other naturalization programs, to claim that physicalism, unlike the sciences, hasn’t proved fruitful.