Autobiographical memory, autonoetic consciousness, and self-perspective in aging

In this study, the authors examined the effects of aging on autobiographical memory in 180 participants by means of a new method designed to assess across 5 lifetime periods the nature of memories-that is, specificity and spontaneity--and the phenomenal experience of remembering--that is, self-perspective and autonoetic consciousness--via the field/observer and remember/know paradigms respectively. Age-related differences were found for the specificity and spontaneity of memories and the phenomenal experience of remembering. There was an increase in observer and know responses with age, but a decrease in field and remember responses and in the ability to justify them by recalling sensory-perceptive, affective, or spatiotemporal specific details. This pattern confirms the existence of a semantic-episodic dissociation in autobiographical memory in aging. Moreover, the data support the view that older participants can subjectively "travel back in time" to relive personal events in the most distant past better than those in the recent past.     

Factors affecting medial temporal lobe engagement for past and future episodic events: an ALE meta-analysis of neuroimaging studies

Remembering the past and envisioning the future are at the core of one's sense of identity. Neuroimaging studies investigating the neural substrates underlying past and future episodic events have been growing in number. However, the experimental paradigms used to select and elicit episodic events vary greatly, leading to disparate results, especially with respect to the laterality and antero-posterior localization of hippocampal and adjacent medial temporal activations (i.e., parahippocampal, entorhinal and perirhinal cortices, amygdala). Although a central concern in today's literature, the issue of hippocampal and medial temporal lobe laterality and antero-posterior segregation in past and future episodic events has not yet been addressed extensively. Using the activation likelihood estimation (ALE) procedure (Turkeltaub, Eden, Jones, & Zeffiro, 2002), we performed a meta-analysis of hippocampal and adjacent medial temporal coordinates extracted from neuroimaging studies examining past remembering and future envisioning. We questioned whether methodological choices could influence the laterality of activations, namely (1) the type of cue used (generic vs. specific), (2) the type of task performed (recognition vs. recall/imagine), (3) the nature of the information retrieved (episodic vs. "strictly" episodic events) and (4) the age of participants. We consider "strictly" episodic events as events which are not only spatio-temporally unique and personal like episodic events, but are also associated with contextual and phenomenological details. These four factors were compared two-by-two, generating eight whole-brain statistical maps. Results indicate that (1) specific cues tend to activate more the right anterior hippocampus compared to the use of generic cues, (2) recall/imagine tasks tend to recruit more the left posterior parahippocampal gyrus compared to recognition tasks, (3) (re/pre)experiencing strictly episodic events tends to activate more the bilateral posterior hippocampus compared to episodic events and (4) older subjects tend to activate more the right anterior hippocampus compared to younger subjects. Importantly, our results stress that strictly episodic events triggered by specific cues elicit greater left posterior hippocampal activation than episodic events triggered by specific cues. These findings suggest that such basic methodological choices have an impact on the conclusions reached regarding past and future (re/pre)experiencing and their neural substrates.     

The Job Demands and Resources Decision Making (JD-R-DM) Model

This study explores the effects of nurses’ daily job characteristics (i.e., job demands and resources) and general work engagement on their daily decision making (i.e., analytical and intuitive) and consequently their daily performance (i.e., task and contextual). Participants completed a baseline questionnaire and a diary for five consecutive days. Results reveal a positive influence of the job demands “work pressure” and “predictability” on analytical decision making. In turn, analytical decision making promotes task performance. Work pressure also negatively influences intuitive decision making which, in turn, stimulates task and contextual performance. However, the job resource (i.e., autonomy) had a nonsignificant relationship with decision making. General work engagement had positive effects on analytical decision making and moderated the relationship between intuitive decision making and contextual performance. For those high on work engagement, the relation was stronger compared to their counterparts low on work engagement. Results corroborate that expanding and testing decision-making theories can increase understanding on how the work environment and engagement influence employee decision making and performance.     

On the relationship between visual imagery and visual perception: Evidence from priming studies

Two priming experiments using a perceptual identification task were conducted to explore the functional and representational overlap between visual imagery and visual perception. The first experiment included a study phase in which primes were either perceived or imaged objects and a perceptual identification test task in which targets were parts of studied and non-studied objects. Imagery primed identification when subjects were instructed to count the parts of the imaged objects in the study phase but not when they were instructed to focus on the global shape of the imaged objects. This result suggests that imagery involves perceptual representations identical to those involved in perception. It also suggests that the representational overlap between imagery and perception depends on the type of images generated, as some images may consist in global shapes only, whereas others may consist in detailed, multi-part shapes. In the second experiment, we used whole objects as target stimuli which provided subjects with more information to identify masked targets and thereby reduced top-down processing. Priming from imagery fell beneath significance, suggesting that this sort of priming is elicited in a large part by a transfer of top-down processes from study to test.     

Moral emotions and the envisaging of mitigating circumstances for wrongdoing

Anger may be more responsive than disgust to mitigating circumstances in judgements of wrongdoing. We tested this hypothesis in two studies where we had participants envision circumstances that could serve to mitigate an otherwise wrongful act. In Study 1, participants provided moral judgements, and ratings of anger and disgust, to a number of transgressions involving either harm or bodily purity. They were then asked to imagine and report whether there might be any circumstances that would make it all right to perform the act. Across transgression type, and controlling for covariance between anger and disgust, levels of anger were found to negatively predict the envisioning of mitigating circumstances for wrongdoing, while disgust was unrelated. Study 2 replicated and extended these findings to less serious transgressions, using a continuous measure of mitigating circumstances, and demonstrated the impact of anger independent of deontological commitments. These findings highlight the differential relationship that anger and disgust have with the ability to envision mitigating factors.     

Route and survey processing of topographical memory during navigation

We investigated the characteristics of route and survey processing of a unique complex virtual environment both at the behavioral and brain levels. Prior to fMRI scanning, participants were trained to follow a route and to learn the spatial relationships between several places, acquiring both route and survey knowledge from a ground-level perspective. During scanning, snapshots of the environment were presented, and participants were required to either indicate the direction to take to follow the route (route task), or to locate unseen targets (survey task). Data suggest that route and survey processing are mainly supported by a common occipito-fronto-parieto-temporal neural network. Our results are consistent with those gathered in studies concerning the neural bases of route versus survey knowledge acquired either from different perspectives or in different environments. However, rather than arguing for a clear distinction between route and survey processing, “mixed” strategies are likely to be involved when both types of encoding take place in the same environment.     

Arguments by Parallels in the Epistemological Works of Phya pa Chos kyi seng ge

The works of the Tibetan logician Phya pa Chos kyi seng ge (1109–1169) make abundant use of a particular type of argument that I term ‘argument by parallels’. Their main characteristic is that the instigator of the argument, addressing a thesis in a domain A, introduces a parallel thesis in an unrelated domain B. And in the ensuing dialogue, each of the instigator’s statements consists in replicating his interlocutor’s previous assertion, mutatis mutandis, in the other domain (A or B). I show that such a dialogue involves two parallel arguments that develop in an intersecting zigzag pattern, and discuss the principles involved in the establishment of the conclusion from the perspective of parity of reasoning and analogical argument. I examine the overall rhetorical strategy directing the use of arguments by parallels and the pedagogical and explanatory functions they can serve. I also evaluate the plausibility of their use in Phya pa Chos kyi seng ge’s works mirroring a contemporary practice of oral debate, and reflect on the status of such arguments in the framework of Indo-Tibetan logic.

Age effects on different components of theory of mind

The effects of aging on the cognitive and affective dimensions of theory of mind (ToM), and on the latter’s links with other cognitive processes, such as information processing speed, executive functions and episodic memory, are still unclear. We therefore investigated these effects in young (n = 25), middle-aged (n = 20) and older adults (n = 25), using separate subjective and objective assessment tasks. Furthermore, a novel composite task probed participants’ abilities to infer both cognitive and affective mental states in an interpersonal context. Although age affected the objective ToM tests, results revealed a direct aging effect on the second-order ToM, but an indirect one on the first-order cognitive ToM, mediated mainly by age-related declines in executive functions. This study supports the notion of an age-related distinction between subjective and objective assessments of ToM, and confirms that ToM is a complex mental ability with several characteristics reliant to some extent on executive processes.     

Listeners feel the beat: Entrainment to English and French speech rhythms

Can listeners entrain to speech rhythms? Monolingual speakers of English and French and balanced English–French bilinguals tapped along with the beat they perceived in sentences spoken in a stress-timed language, English, and a syllable-timed language, French. All groups of participants tapped more regularly to English than to French utterances. Tapping performance was also influenced by the participants’ native language: English-speaking participants and bilinguals tapped more regularly and at higher metrical levels than did French-speaking participants, suggesting that long-term linguistic experience with a stress-timed language can differentiate speakers’ entrainment to speech rhythm.     

The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo

The neural cell adhesion molecule (NCAM) is known to play a role in developmental and structural processes but also in synaptic plasticity and memory of the adult animal. Recently, FGL, a NCAM mimetic peptide that binds to the Fibroblast Growth Factor Receptor 1 (FGFR-1), has been shown to have a beneficial impact on normal memory functioning, as well as to rescue some pathological cognitive impairments. Whether its facilitating impact may be mediated through promoting neuronal plasticity is not known. The present study was therefore designed to test whether FGL modulates the induction and maintenance of synaptic plasticity in the dentate gyrus (DG) in vivo. For this, we first assessed the effect of the FGL peptide on synaptic functions at perforant path-dentate gyrus synapses in the anesthetized rat. FGL, or its control inactive peptide, was injected locally 60 min before applying high-frequency stimulation (HFS) to the medial perforant path. The results suggest that although FGL did not alter basal synaptic transmission, it facilitated both the induction and maintenance of LTP. Interestingly, FGL also modified the heterosynaptic plasticity observed at the neighboring lateral perforant path synapses. The second series of experiments, using FGL intracerebroventricular infusion in the awake animal, confirmed its facilitating effect on LTP for up to 24 h. Our data also suggest that FGL could alter neurogenesis associated with LTP. In sum, these results show for the first time that enhancing NCAM functions by mimicking its heterophilic interaction with FGFR facilitates hippocampal synaptic plasticity in the awake, freely moving animal.