Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning

Recent work from a number of laboratories has provided new and important insights about how gene expression is altered by experience and how these molecular changes may provide a substrate for the long-term storage of new memories. Here, we review a series of recent studies using aversive Pavlovian conditioning in rats as a well characterized model system in which experience-dependent alterations in gene expression can be manipulated and quantified within a specific neural circuit. We highlight some of the issues involved in using broad-spectrum inhibitors of mRNA and protein synthesis to study cellular changes underlying the formation and long-term stability of memory and discuss the idea that these changes occur over widespread, behaviorally-defined, networks of cells. We also discuss the idea that the maintenance of memory and its susceptibly to disruption after retrieval may relate to local protein synthesis in dendrites. Finally, a series of recent experiments from our laboratory studying the role of a specific signaling pathway (mTOR) which regulates translational processes and memory formation in the amygdala and hippocampus during fear conditioning are reviewed.     

Raiding the inarticulate: The internal analytic setting and listening beyond countertransference

The analytic setting exists not only externally but also internally as a structure in the mind of the analyst. The internal analytic setting constitutes an area of the analyst's mind where reality is defined by unconscious symbolic meaning. Clinical examples illustrate how a secure internal setting allows flexibility in the external setting without sacrifice of its analytic quality. The internal setting can help analysts listen inwardly to themselves in a way that is free-floating with regard to their internal processes. This points beyond usual ideas of countertransference. An analytic encounter may stir up elements that belong to the analyst's psyche which, rather than impeding the analysis, can actively enrich it. Seamus Heaney's writings evoke comparisons between listening to poems and listening to patients, and a week in a patient's analysis is described in relation to these themes.     

The temporal relationship between alcohol consumption and HIV-medication adherence: a multilevel model of direct and moderating effects

Previous studies documenting an association between alcohol use and HIV medication nonadherence, have been unable to distinguish between-persons characteristics from within-person characteristics representing the temporally linked effects of alcohol. Hierarchical Linear Modeling (HLM) explored within- and between-person predictors of adherence during the past 14 days, as well as factors that moderate the event-level effects of alcohol consumption among 272 HIV-positive men and women with alcohol problems. On days in which participants drank, they had almost 9 times higher odds of medication nonadherence, with each drink increasing the odds by 20%. The cognitive and alcohol factors had significant between-person effects on adherence. Individuals with strong and rigid beliefs about the importance of strict medication adherence were significantly more affected by each dose of alcohol, while individuals with more alcohol use and problems were less affected by each drink. Regimen complexity increased the effects of having 1 or more drinks. These results highlight the importance of promoting medication adherence among alcohol-using adults, especially among patients with complex regimens or with high confidence and positive attitudes toward HIV medication.     

Why Should We Save Nature's Hidden Gems?

Aesthetic preservation is the idea of sparing natural areas from development because of their aesthetic value. In this article I discuss a problem for aesthetic preservation that I call the ‘hidden gems problem’: in certain cases, the natural area under consideration is so remote and/or fragile that few people can actually experience it. In these cases, it becomes unclear how nature's aesthetic value can justify its preservation when development promises practical human benefits. After rejecting some potential responses to the hidden gems problem, I offer a different solution. I argue that we have an aesthetic reason to preserve nature's hidden gems because they are required to produce ‘true judges’ of aesthetic value, who are capable of improving the general quality of taste for landscape. I develop this argument using the example of recent preservationist efforts to save the isolated landscape of Sable Island, Nova Scotia.     

Conceiving of God: Theological arguments and motives in feminist ethics

This paper offers a critical investigation of the theological assumptions that lie within three forms of modern feminist ethics, with a view to challenging feminist ethics to enter the new theological possibilities opened up in postmodernity for the conceiving of god. The first part of the paper considers the conceiving of god in modern feminisms, in which theology becomes ethics. The consequences of this development are considered. The second part of the paper investigates the turn into postmodernity which hears the saying of the death of god and the critique of onto-theology. This disturbance to the foundations of feminist ethics is understood as part of a wider critique of humanism manifest particularly in gender theory. That the end of the modern human subject might allow a conceiving of god through an understanding of the performative is the restored orthodoxy to which the paper points.     

The effect of varying danger controllability on attention to threat messages

The objective of this study is to determine whether attention toward fear messages is affected by variation in the controllability of the associated danger. There is no consensus regarding the effectiveness of fear appeals in driving adaptive behaviour, and it may be the case that threat messages fail to capture attention if the associated danger is not explicitly controllable. One hundred and sixty undergraduate university students completed a computer task that involved exposure to threat cues signalling a danger (money loss). In high control blocks, attending to threat cues provided a high chance of avoiding the danger, whereas in low control blocks, attending to threat cues provided little chance of avoiding the danger. Attentional capture by threat was measured. A mixed-design analysis of variance showed there was greater attentional capture by threat cues in high control blocks compared with low control blocks. This effect was observed with a short stimulus exposure duration and was magnified with a long exposure duration. Fear appeals could capture attention to a greater degree if the danger related to the threat message was communicated as being controllable. This has significant practical implications for the implementation of fear appeals.     

Conceptual Conservatism and Contingent Composition

This paper proposes a novel answer to the Special Composition Question. In some respects it agrees with brutalism about composition; in others with universalism. The main novel feature of this answer is the insight I think it gives into what the debate over the Special Composition Question is about.     

Superior parietal cortices and varieties of mental rotation

Mental rotation is the most distinctly specialized operation of the imagination, one characterized precisely enough psychophysically for parametric study, thereby making it an optimal prospect for isolating and modeling its neural mechanisms. New human brain mapping studies using direct cortical stimulation and repetitive transcranial magnetic stimulation isolate an area in right superior parietal cortex that appears to be crucial for the mental rotation of objects, but not to the mental rotation of one's body.